Distinct origins and molecular mechanisms contribute to lymphatic formation during cardiac growth and regeneration
In recent years, there has been increasing interest in the role of lymphatics in organ repair and regeneration, due to their importance in immune surveillance and fluid homeostasis. Experimental approaches aimed at boosting lymphangiogenesis following myocardial infarction in mice, were shown to pro...
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doaj-8723b2ae3cd64787ad7c55f1ed50a5292021-05-05T18:04:47ZengeLife Sciences Publications LtdeLife2050-084X2019-11-01810.7554/eLife.44153Distinct origins and molecular mechanisms contribute to lymphatic formation during cardiac growth and regenerationDana Gancz0Brian C Raftrey1Gal Perlmoter2https://orcid.org/0000-0003-2017-3008Rubén Marín-Juez3https://orcid.org/0000-0001-5903-7463Jonathan Semo4Ryota L Matsuoka5https://orcid.org/0000-0001-6214-2889Ravi Karra6Hila Raviv7Noga Moshe8Yoseph Addadi9Ofra Golani10https://orcid.org/0000-0002-9793-236XKenneth D Poss11Kristy Red-Horse12Didier YR Stainier13https://orcid.org/0000-0002-0382-0026Karina Yaniv14https://orcid.org/0000-0001-5638-7150Department of Biological Regulation, Weizmann Institute of Science, Rehovot, IsraelDepartment of Biology, Stanford University, Stanford, United States; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, United StatesDepartment of Biological Regulation, Weizmann Institute of Science, Rehovot, IsraelDepartment of Developmental Genetics, Max Planck Institute for Heart and Lung Research, Bad Nauheim, GermanyDepartment of Biological Regulation, Weizmann Institute of Science, Rehovot, IsraelDepartment of Developmental Genetics, Max Planck Institute for Heart and Lung Research, Bad Nauheim, GermanyRegeneration Next, Duke University, Durham, United States; Department of Medicine, Duke University School of Medicine, Durham, United StatesDepartment of Biological Regulation, Weizmann Institute of Science, Rehovot, IsraelDepartment of Biological Regulation, Weizmann Institute of Science, Rehovot, IsraelDepartment of Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot, IsraelDepartment of Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot, IsraelRegeneration Next, Duke University, Durham, United StatesDepartment of Biology, Stanford University, Stanford, United States; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, United StatesDepartment of Developmental Genetics, Max Planck Institute for Heart and Lung Research, Bad Nauheim, GermanyDepartment of Biological Regulation, Weizmann Institute of Science, Rehovot, IsraelIn recent years, there has been increasing interest in the role of lymphatics in organ repair and regeneration, due to their importance in immune surveillance and fluid homeostasis. Experimental approaches aimed at boosting lymphangiogenesis following myocardial infarction in mice, were shown to promote healing of the heart. Yet, the mechanisms governing cardiac lymphatic growth remain unclear. Here, we identify two distinct lymphatic populations in the hearts of zebrafish and mouse, one that forms through sprouting lymphangiogenesis, and the other by coalescence of isolated lymphatic cells. By tracing the development of each subset, we reveal diverse cellular origins and differential response to signaling cues. Finally, we show that lymphatic vessels are required for cardiac regeneration in zebrafish as mutants lacking lymphatics display severely impaired regeneration capabilities. Overall, our results provide novel insight into the mechanisms underlying lymphatic formation during development and regeneration, opening new avenues for interventions targeting specific lymphatic populations.https://elifesciences.org/articles/44153lymphaticscardiacregeneration |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Dana Gancz Brian C Raftrey Gal Perlmoter Rubén Marín-Juez Jonathan Semo Ryota L Matsuoka Ravi Karra Hila Raviv Noga Moshe Yoseph Addadi Ofra Golani Kenneth D Poss Kristy Red-Horse Didier YR Stainier Karina Yaniv |
spellingShingle |
Dana Gancz Brian C Raftrey Gal Perlmoter Rubén Marín-Juez Jonathan Semo Ryota L Matsuoka Ravi Karra Hila Raviv Noga Moshe Yoseph Addadi Ofra Golani Kenneth D Poss Kristy Red-Horse Didier YR Stainier Karina Yaniv Distinct origins and molecular mechanisms contribute to lymphatic formation during cardiac growth and regeneration eLife lymphatics cardiac regeneration |
author_facet |
Dana Gancz Brian C Raftrey Gal Perlmoter Rubén Marín-Juez Jonathan Semo Ryota L Matsuoka Ravi Karra Hila Raviv Noga Moshe Yoseph Addadi Ofra Golani Kenneth D Poss Kristy Red-Horse Didier YR Stainier Karina Yaniv |
author_sort |
Dana Gancz |
title |
Distinct origins and molecular mechanisms contribute to lymphatic formation during cardiac growth and regeneration |
title_short |
Distinct origins and molecular mechanisms contribute to lymphatic formation during cardiac growth and regeneration |
title_full |
Distinct origins and molecular mechanisms contribute to lymphatic formation during cardiac growth and regeneration |
title_fullStr |
Distinct origins and molecular mechanisms contribute to lymphatic formation during cardiac growth and regeneration |
title_full_unstemmed |
Distinct origins and molecular mechanisms contribute to lymphatic formation during cardiac growth and regeneration |
title_sort |
distinct origins and molecular mechanisms contribute to lymphatic formation during cardiac growth and regeneration |
publisher |
eLife Sciences Publications Ltd |
series |
eLife |
issn |
2050-084X |
publishDate |
2019-11-01 |
description |
In recent years, there has been increasing interest in the role of lymphatics in organ repair and regeneration, due to their importance in immune surveillance and fluid homeostasis. Experimental approaches aimed at boosting lymphangiogenesis following myocardial infarction in mice, were shown to promote healing of the heart. Yet, the mechanisms governing cardiac lymphatic growth remain unclear. Here, we identify two distinct lymphatic populations in the hearts of zebrafish and mouse, one that forms through sprouting lymphangiogenesis, and the other by coalescence of isolated lymphatic cells. By tracing the development of each subset, we reveal diverse cellular origins and differential response to signaling cues. Finally, we show that lymphatic vessels are required for cardiac regeneration in zebrafish as mutants lacking lymphatics display severely impaired regeneration capabilities. Overall, our results provide novel insight into the mechanisms underlying lymphatic formation during development and regeneration, opening new avenues for interventions targeting specific lymphatic populations. |
topic |
lymphatics cardiac regeneration |
url |
https://elifesciences.org/articles/44153 |
work_keys_str_mv |
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