Identification of Marek’s Disease Virus VP22 Tegument Protein Domains Essential for Virus Cell-to-Cell Spread, Nuclear Localization, Histone Association and Cell-Cycle Arrest

Identification of Marek’s Disease Virus VP22 Tegument Protein Domains Essential for Virus Cell-to-Cell Spread, Nuclear Localization, Histone Association and Cell-Cycle Arrest

VP22 is a major tegument protein of alphaherpesviruses encoded by the <i>UL49</i> gene. Two properties of VP22 were discovered by studying Marek&#8217;s disease virus (MDV), the Mardivirus prototype; it has a major role in virus cell-to-cell spread and in cell cycle modulation. This...

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Bibliographic Details
Main Authors: Laëtitia Trapp-Fragnet, Katia Courvoisier, Sylvie Rémy, G. Le Pape, Fabien Loustalot, Caroline Denesvre
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Viruses
Subjects:
Alphaherpesvirus
VP22
virus spread
cell cycle
subcellular localization
histones
Marek’s disease virus
functional domains
Online Access:https://www.mdpi.com/1999-4915/11/6/537

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