Circulating levels of adipose tissue-derived inflammatory factors in elderly diabetes patients with carotid atherosclerosis: a retrospective study
Abstract Background Inflammation has been recognized as a key feature of both type 2 diabetes mellitus (T2DM) and atherosclerosis. However, the relationships between circulating levels of novel adipose tissue-derived inflammatory factors, including resistin, vaspin, and visfatin, and the severity of...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2018-05-01
|
Series: | Cardiovascular Diabetology |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s12933-018-0723-y |
id |
doaj-8762f16c646c4908a95e4e4103d90553 |
---|---|
record_format |
Article |
spelling |
doaj-8762f16c646c4908a95e4e4103d905532020-11-25T02:45:50ZengBMCCardiovascular Diabetology1475-28402018-05-011711910.1186/s12933-018-0723-yCirculating levels of adipose tissue-derived inflammatory factors in elderly diabetes patients with carotid atherosclerosis: a retrospective studyWei Yang0Yun Li1Jie-Yu Wang2Rui Han3Li Wang4Department of Geriatric Medicine, Capital Medical University, Xuanwu HospitalDepartment of Geriatric Medicine, Capital Medical University, Xuanwu HospitalDepartment of Geriatric Medicine, Capital Medical University, Xuanwu HospitalDepartment of Geriatric Medicine, Capital Medical University, Xuanwu HospitalDepartment of Endocrine, Capital Medical University, Xuanwu HospitalAbstract Background Inflammation has been recognized as a key feature of both type 2 diabetes mellitus (T2DM) and atherosclerosis. However, the relationships between circulating levels of novel adipose tissue-derived inflammatory factors, including resistin, vaspin, and visfatin, and the severity of atherosclerosis have not been determined. Moreover, the associations between these inflammatory factors and obesity and insulin resistance in elderly patients remain to be clarified. Methods A cross-sectional study of 256 elderly patients with T2DM admitted in our center was performed. Baseline circulating levels of resistin, vaspin and visfatin were measured with enzyme-linked immunosorbent assays. Ultrasonic evaluations of the carotid arteries of the patients were performed to reflect the severity of systemic atherosclerosis. Patients were classified as having mild, moderate, or severe atherosclerosis according to the results of carotid ultrasonic examination. Circulating levels of the inflammatory factors listed above also were correlated with body mass index (BMI) and homeostasis model assessment of insulin resistance (HOMA-IR). Results With more severe carotid atherosclerosis, circulating levels of resistin (mild: 2.01 ± 0.23; moderate: 2.89 ± 1.01; severe: 3.12 ± 1.12; p < 0.05) and visfatin (mild: 11.63 ± 7.48; moderate: 15.24 ± 2.19; severe: 17.54 ± 2.98; p < 0.05) gradually increased, while level of vaspin decreased (mild: 317 ± 23.12; moderate: 269 ± 32.12; severe: 229 ± 14.24; p < 0.05). Subsequent results of Pearson coefficient analyses indicated that all of the tested adipose tissue-derived inflammatory factors were positively correlated with the BMI and HOMA-IR of the patients (all p < 0.05), even after adjustment for hs-CRP. Conclusions The adipose tissue-derived inflammatory factors resistin, vaspin and visfatin may be involved in the pathogenesis of atherosclerosis in elderly T2DM patients.http://link.springer.com/article/10.1186/s12933-018-0723-yVaspinResistinVisfatinDiabetes mellitusAtherosclerosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Wei Yang Yun Li Jie-Yu Wang Rui Han Li Wang |
spellingShingle |
Wei Yang Yun Li Jie-Yu Wang Rui Han Li Wang Circulating levels of adipose tissue-derived inflammatory factors in elderly diabetes patients with carotid atherosclerosis: a retrospective study Cardiovascular Diabetology Vaspin Resistin Visfatin Diabetes mellitus Atherosclerosis |
author_facet |
Wei Yang Yun Li Jie-Yu Wang Rui Han Li Wang |
author_sort |
Wei Yang |
title |
Circulating levels of adipose tissue-derived inflammatory factors in elderly diabetes patients with carotid atherosclerosis: a retrospective study |
title_short |
Circulating levels of adipose tissue-derived inflammatory factors in elderly diabetes patients with carotid atherosclerosis: a retrospective study |
title_full |
Circulating levels of adipose tissue-derived inflammatory factors in elderly diabetes patients with carotid atherosclerosis: a retrospective study |
title_fullStr |
Circulating levels of adipose tissue-derived inflammatory factors in elderly diabetes patients with carotid atherosclerosis: a retrospective study |
title_full_unstemmed |
Circulating levels of adipose tissue-derived inflammatory factors in elderly diabetes patients with carotid atherosclerosis: a retrospective study |
title_sort |
circulating levels of adipose tissue-derived inflammatory factors in elderly diabetes patients with carotid atherosclerosis: a retrospective study |
publisher |
BMC |
series |
Cardiovascular Diabetology |
issn |
1475-2840 |
publishDate |
2018-05-01 |
description |
Abstract Background Inflammation has been recognized as a key feature of both type 2 diabetes mellitus (T2DM) and atherosclerosis. However, the relationships between circulating levels of novel adipose tissue-derived inflammatory factors, including resistin, vaspin, and visfatin, and the severity of atherosclerosis have not been determined. Moreover, the associations between these inflammatory factors and obesity and insulin resistance in elderly patients remain to be clarified. Methods A cross-sectional study of 256 elderly patients with T2DM admitted in our center was performed. Baseline circulating levels of resistin, vaspin and visfatin were measured with enzyme-linked immunosorbent assays. Ultrasonic evaluations of the carotid arteries of the patients were performed to reflect the severity of systemic atherosclerosis. Patients were classified as having mild, moderate, or severe atherosclerosis according to the results of carotid ultrasonic examination. Circulating levels of the inflammatory factors listed above also were correlated with body mass index (BMI) and homeostasis model assessment of insulin resistance (HOMA-IR). Results With more severe carotid atherosclerosis, circulating levels of resistin (mild: 2.01 ± 0.23; moderate: 2.89 ± 1.01; severe: 3.12 ± 1.12; p < 0.05) and visfatin (mild: 11.63 ± 7.48; moderate: 15.24 ± 2.19; severe: 17.54 ± 2.98; p < 0.05) gradually increased, while level of vaspin decreased (mild: 317 ± 23.12; moderate: 269 ± 32.12; severe: 229 ± 14.24; p < 0.05). Subsequent results of Pearson coefficient analyses indicated that all of the tested adipose tissue-derived inflammatory factors were positively correlated with the BMI and HOMA-IR of the patients (all p < 0.05), even after adjustment for hs-CRP. Conclusions The adipose tissue-derived inflammatory factors resistin, vaspin and visfatin may be involved in the pathogenesis of atherosclerosis in elderly T2DM patients. |
topic |
Vaspin Resistin Visfatin Diabetes mellitus Atherosclerosis |
url |
http://link.springer.com/article/10.1186/s12933-018-0723-y |
work_keys_str_mv |
AT weiyang circulatinglevelsofadiposetissuederivedinflammatoryfactorsinelderlydiabetespatientswithcarotidatherosclerosisaretrospectivestudy AT yunli circulatinglevelsofadiposetissuederivedinflammatoryfactorsinelderlydiabetespatientswithcarotidatherosclerosisaretrospectivestudy AT jieyuwang circulatinglevelsofadiposetissuederivedinflammatoryfactorsinelderlydiabetespatientswithcarotidatherosclerosisaretrospectivestudy AT ruihan circulatinglevelsofadiposetissuederivedinflammatoryfactorsinelderlydiabetespatientswithcarotidatherosclerosisaretrospectivestudy AT liwang circulatinglevelsofadiposetissuederivedinflammatoryfactorsinelderlydiabetespatientswithcarotidatherosclerosisaretrospectivestudy |
_version_ |
1724759755783667712 |