Enhanced synaptic activity and epileptiform events in the embryonic Kcc2 deficient hippocampus

Enhanced synaptic activity and epileptiform events in the embryonic Kcc2 deficient hippocampus

The neuronal potassium-chloride co-transporter Kcc2 is thought to play an important role in the post natal excitatory to inhibitory switch of GABA actions in the rodent hippocampus. Here, by studying hippocampi of wild-type (Kcc2+/+) and Kcc2 deficient (Kcc2-/-) mouse embryos, we unexpectedly found...

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Bibliographic Details
Main Authors: Ilgam eKhalilov, Geneviève eChazal, Ilona eChudotvorova, Christophe ePellegrino, Severine eCorby, Nadine eFerrand, Olena eGubkina, Romain eNardou, Roman eTyzio, Sumii eYamamoto, Thomas J Jentsch, Christian eHubner, Jean-Luc eGaiarsa, Yehezkel eBen-Ari, Igor eMedina
Format: Article
Language:English
Published: Frontiers Media S.A. 2011-11-01
Series:Frontiers in Cellular Neuroscience
Subjects:
development
GABA
KCC2
network
Neuron
synapse
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2011.00023/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2011.00023/full

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