Enhanced synaptic activity and epileptiform events in the embryonic Kcc2 deficient hippocampus

Enhanced synaptic activity and epileptiform events in the embryonic Kcc2 deficient hippocampus

The neuronal potassium-chloride co-transporter Kcc2 is thought to play an important role in the post natal excitatory to inhibitory switch of GABA actions in the rodent hippocampus. Here, by studying hippocampi of wild-type (Kcc2+/+) and Kcc2 deficient (Kcc2-/-) mouse embryos, we unexpectedly found...

Full description

Bibliographic Details
Main Authors:	Ilgam eKhalilov, Geneviève eChazal, Ilona eChudotvorova, Christophe ePellegrino, Severine eCorby, Nadine eFerrand, Olena eGubkina, Romain eNardou, Roman eTyzio, Sumii eYamamoto, Thomas J Jentsch, Christian eHubner, Jean-Luc eGaiarsa, Yehezkel eBen-Ari, Igor eMedina
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2011-11-01
Series:	Frontiers in Cellular Neuroscience
Subjects:	development GABA KCC2 network Neuron synapse
Online Access:	http://journal.frontiersin.org/Journal/10.3389/fncel.2011.00023/full

Similar Items

Phenobarbital but not diazepam reduces AMPA/Kainate receptor mediated currents and exerts opposite actions on initial seizures in the neonatal rat hippocampus
by: Romain eNardou, et al.
Published: (2011-07-01)

Emerging neurotrophic role of GABAB receptors in neuronal circuit development
by: Jean-Luc eGaiarsa, et al.
Published: (2013-11-01)

Leptin potentiates GABAergic synaptic transmission in the developing rodent hippocampus.
by: Damien eGuimond, et al.
Published: (2014-08-01)

A unique array of neuroprotective effects of Pyruvate in neuropathology
by: Yuri eZilberter, et al.
Published: (2015-02-01)

Orthographic consistency and word-frequency effects in auditory word recognition: New evidence from lexical decision and rime detection
by: Ana ePetrova, et al.
Published: (2011-10-01)

Recognition of extracellular bacteria by NLRs and its role in the development of adaptive immunity
by: Jonathan eFerrand, et al.
Published: (2013-10-01)

Editorial: Improving the safety of cell therapy products by suicide gene transfer
by: Elodie eBole-Richard, et al.
Published: (2015-08-01)

Newborn analgesia mediated by oxytocin during delivery
by: Michel eMazzuca, et al.
Published: (2011-04-01)

Detrimental effect of post Status Epilepticus treatment with ROCK inhibitor Y-27632 in a pilocarpine model of temporal lobe epilepsy.
by: NAZIM eKOURDOUGLI, et al.
Published: (2015-10-01)

Current view on the functional regulation of the neuronal K+-Cl- cotransporter KCC2
by: Igor eMedina, et al.
Published: (2014-02-01)

Early hypersynchrony in juvenile PINK1-/- motor cortex is rescued by antidromic stimulation
by: Romain eCARRON, et al.
Published: (2014-05-01)

RAGE-mediated inflammation, type 2 diabetes and diabetic vascular complication
by: Yasuhiko eYamamoto, et al.
Published: (2013-08-01)

Interplay between ubiquitin, SUMO and poly(ADP-ribose) in the cellular response to genotoxic stress
by: Stefania ePellegrino, et al.
Published: (2016-04-01)

Re-encoding of Associations by Recurrent Plasticity Increases Memory Capacity
by: Daniel eMedina, et al.
Published: (2014-06-01)

Comparing word processing times in naming, lexical decision, and progressive demasking:Evidence from Chronolex
by: Ludovic eFerrand, et al.
Published: (2011-11-01)

Improved method for efficient imaging of intracellular Cl- with Cl-Sensor using conventional fluorescence setup
by: Perrine eFriedel, et al.
Published: (2013-04-01)

Lateral Habenula determines long-term storage of aversive memories.
by: Micol eTomaiuolo, et al.
Published: (2014-05-01)

Interword and intraword pause threshold in the writing of texts by children and adolescents : a methodological approach
by: Florence eChenu, et al.
Published: (2014-03-01)

Sulfur metabolisms in epsilon- and gamma-Proteobacteria in deep-sea hydrothermal fields
by: Masahiro eYamamoto, et al.
Published: (2011-09-01)

The expanding world of extracellular traps: not only neutrophils but much more
by: Oliver eGoldmann, et al.
Published: (2013-01-01)

The need for better AD animal models
by: Miguel eMedina, et al.
Published: (2014-10-01)

Refuting the challenges of the developmental shift of polarity of GABA actions: GABA more exciting than ever!
by: Yehezkel eBen-Ari, et al.
Published: (2012-08-01)

In vivo calcium imaging of evoked calcium waves in the embryonic cortex
by: Mikhail eYuryev, et al.
Published: (2016-01-01)

Deregulation of the actin cytoskeleton and macropinocytosis in response to phorbol ester by the mutant protein kinase C gamma that causes spinocerebellar ataxia type 14
by: Kazuhiro eYamamoto, et al.
Published: (2014-04-01)

Brain mechanisms of flavor learning
by: Takashi eYamamoto, et al.
Published: (2011-09-01)

The evolution of dopamine systems in chordates
by: Kei eYamamoto, et al.
Published: (2011-03-01)

Effect of climate change on Aspergillus flavus and aflatoxin B1 production
by: Angel eMedina, et al.
Published: (2014-07-01)

Combinatorial expression of Lef1, Lhx2, Lhx5, Lhx9, Lmo3, Lmo4, and Prox1 helps to identify comparable subdivisions in the developing hippocampal formation of mouse and chicken
by: Antonio eAbellán, et al.
Published: (2014-07-01)

The role of extracellular Tau in the spreading of neurofibrillary pathology
by: Miguel eMedina, et al.
Published: (2014-04-01)

Entanglement production under electron phonon interaction in a quantum dot
by: A.Lopez, et al.
Published: (2006-01-01)

Skeletal muscle homeostasis in Duchenne muscular dystrophy: modulating autophagy as a promising therapeutic strategy
by: Clara eDe Palma, et al.
Published: (2014-07-01)

The Keap1-Nrf2 system in cancers: Stress response and anabolic metabolism
by: Yoichiro eMitsuishi, et al.
Published: (2012-12-01)

Application of insulin-like growth factor 1 in the treatment of inner ear disorders
by: Norio eYamamoto, et al.
Published: (2014-09-01)

VASCULAR AGING IN WOMEN: IS ESTROGEN THE FOUNTAIN OF YOUTH?
by: Susana eNovella, et al.
Published: (2012-06-01)

Genetic identification of the central nucleus and other components of the central extended amygdala in chicken during development
by: Alba eVicario, et al.
Published: (2014-09-01)

The yin and yen of GABA in brain development and operation in health and disease
by: Yehezkel eBen-Ari
Published: (2012-11-01)

A Commentary on the paper by Kirmse et al published by nature communication entitled GABA depolarizesimmature neurons and inhibbits network activity in the neontala cortex in vivo Nature*Communication,*2015*Jul* 16;6:7750*!Title: Are the in vivo actions of GABA on very immature neurons more reliable than in slices ?
by: Yehezkel eBen-Ari
Published: (2015-12-01)

Neural mechanisms of social dominance
by: Noriya eWatanabe, et al.
Published: (2015-06-01)

Epigenetic alteration and microRNA dysregulation in cancer
by: Hiromu eSuzuki, et al.
Published: (2013-12-01)

Nonlinear electrical impedance spectroscopy of viruses using very high electric fields created by nanogap electrodes
by: Ryuji eHatsuki, et al.
Published: (2015-09-01)