Impact of commonly used drugs on the composition and metabolic function of the gut microbiota

Here, via a metagenomics analysis of population-based and disease cohorts, Vich Vila et al. study the impact of 41 commonly used medications on the taxonomic structures, metabolic potential and resistome of the gut microbiome, underscoring the importance of correcting for multiple drug use in microb...

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Main Authors: Arnau Vich Vila, Valerie Collij, Serena Sanna, Trishla Sinha, Floris Imhann, Arno R. Bourgonje, Zlatan Mujagic, Daisy M. A. E. Jonkers, Ad A. M. Masclee, Jingyuan Fu, Alexander Kurilshikov, Cisca Wijmenga, Alexandra Zhernakova, Rinse K. Weersma
Format: Article
Language:English
Published: Nature Publishing Group 2020-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-14177-z
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spelling doaj-877318e8d3ad4c1b9c92da30248a0cb02021-05-11T08:45:02ZengNature Publishing GroupNature Communications2041-17232020-01-0111111110.1038/s41467-019-14177-zImpact of commonly used drugs on the composition and metabolic function of the gut microbiotaArnau Vich Vila0Valerie Collij1Serena Sanna2Trishla Sinha3Floris Imhann4Arno R. Bourgonje5Zlatan Mujagic6Daisy M. A. E. Jonkers7Ad A. M. Masclee8Jingyuan Fu9Alexander Kurilshikov10Cisca Wijmenga11Alexandra Zhernakova12Rinse K. Weersma13Dept. of Gastroenterology and Hepatology, University of Groningen and University Medical Center GroningenDept. of Gastroenterology and Hepatology, University of Groningen and University Medical Center GroningenDept. of Genetics, University of Groningen and University Medical Center GroningenDept. of Genetics, University of Groningen and University Medical Center GroningenDept. of Gastroenterology and Hepatology, University of Groningen and University Medical Center GroningenDept. of Gastroenterology and Hepatology, University of Groningen and University Medical Center GroningenDivision Gastroenterology Hepatology, Maastricht University Medical CenterDivision Gastroenterology Hepatology, Maastricht University Medical CenterDivision Gastroenterology Hepatology, Maastricht University Medical CenterDept. of Genetics, University of Groningen and University Medical Center GroningenDept. of Genetics, University of Groningen and University Medical Center GroningenDept. of Genetics, University of Groningen and University Medical Center GroningenDept. of Genetics, University of Groningen and University Medical Center GroningenDept. of Gastroenterology and Hepatology, University of Groningen and University Medical Center GroningenHere, via a metagenomics analysis of population-based and disease cohorts, Vich Vila et al. study the impact of 41 commonly used medications on the taxonomic structures, metabolic potential and resistome of the gut microbiome, underscoring the importance of correcting for multiple drug use in microbiome studies.https://doi.org/10.1038/s41467-019-14177-z
collection DOAJ
language English
format Article
sources DOAJ
author Arnau Vich Vila
Valerie Collij
Serena Sanna
Trishla Sinha
Floris Imhann
Arno R. Bourgonje
Zlatan Mujagic
Daisy M. A. E. Jonkers
Ad A. M. Masclee
Jingyuan Fu
Alexander Kurilshikov
Cisca Wijmenga
Alexandra Zhernakova
Rinse K. Weersma
spellingShingle Arnau Vich Vila
Valerie Collij
Serena Sanna
Trishla Sinha
Floris Imhann
Arno R. Bourgonje
Zlatan Mujagic
Daisy M. A. E. Jonkers
Ad A. M. Masclee
Jingyuan Fu
Alexander Kurilshikov
Cisca Wijmenga
Alexandra Zhernakova
Rinse K. Weersma
Impact of commonly used drugs on the composition and metabolic function of the gut microbiota
Nature Communications
author_facet Arnau Vich Vila
Valerie Collij
Serena Sanna
Trishla Sinha
Floris Imhann
Arno R. Bourgonje
Zlatan Mujagic
Daisy M. A. E. Jonkers
Ad A. M. Masclee
Jingyuan Fu
Alexander Kurilshikov
Cisca Wijmenga
Alexandra Zhernakova
Rinse K. Weersma
author_sort Arnau Vich Vila
title Impact of commonly used drugs on the composition and metabolic function of the gut microbiota
title_short Impact of commonly used drugs on the composition and metabolic function of the gut microbiota
title_full Impact of commonly used drugs on the composition and metabolic function of the gut microbiota
title_fullStr Impact of commonly used drugs on the composition and metabolic function of the gut microbiota
title_full_unstemmed Impact of commonly used drugs on the composition and metabolic function of the gut microbiota
title_sort impact of commonly used drugs on the composition and metabolic function of the gut microbiota
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-01-01
description Here, via a metagenomics analysis of population-based and disease cohorts, Vich Vila et al. study the impact of 41 commonly used medications on the taxonomic structures, metabolic potential and resistome of the gut microbiome, underscoring the importance of correcting for multiple drug use in microbiome studies.
url https://doi.org/10.1038/s41467-019-14177-z
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