Approaches to correction of immunosuppressive therapy in chronic nephrotoxicity of calcineurin inhibitors

Approaches to correction of immunosuppressive therapy in chronic nephrotoxicity of calcineurin inhibitors

Chronic nephrotoxicity of calcineurin inhibitors (CNI-nephrotoxicity) is one of the most common causes of kidney graft dysfunction requiring correction of maintenance immunosuppressive therapy.The aim of the study was to compare the efficacy and safety of the two possible approaches to dose adjustme...

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Bibliographic Details
Main Authors: E. S. Stolyarevich, J. G. Kim, L. Yu. Artyukhina, L. G. Kurenkova, N. D. Fedorova, N. A. Tomilin
Format: Article
Language:English
Published: N.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare Department 2018-08-01
Series:Transplantologiâ
Subjects:
kidney transplantation
immunosuppressive therapy
chronic nephrotoxicity
calcineurin inhibitors
cyclosporine
Online Access:https://www.jtransplantologiya.ru/jour/article/view/355
Description
Summary:Chronic nephrotoxicity of calcineurin inhibitors (CNI-nephrotoxicity) is one of the most common causes of kidney graft dysfunction requiring correction of maintenance immunosuppressive therapy.The aim of the study was to compare the efficacy and safety of the two possible approaches to dose adjustment of cyclosporine in patients with dysfunction of the transplanted kidney due to CNI-nephrotoxicity. It was established that the main cause of the abolition of Everolimus was proteinuria of nephrotic levels, developed in 19% of patients.
ISSN:2074-0506
2542-0909

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