Approaches to correction of immunosuppressive therapy in chronic nephrotoxicity of calcineurin inhibitors

Chronic nephrotoxicity of calcineurin inhibitors (CNI-nephrotoxicity) is one of the most common causes of kidney graft dysfunction requiring correction of maintenance immunosuppressive therapy.The aim of the study was to compare the efficacy and safety of the two possible approaches to dose adjustme...

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Main Authors:	E. S. Stolyarevich, J. G. Kim, L. Yu. Artyukhina, L. G. Kurenkova, N. D. Fedorova, N. A. Tomilin
Format:	Article
Language:	English
Published:	N.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare Department 2018-08-01
Series:	Transplantologiâ
Subjects:	kidney transplantation immunosuppressive therapy chronic nephrotoxicity calcineurin inhibitors cyclosporine
Online Access:	https://www.jtransplantologiya.ru/jour/article/view/355

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spelling	doaj-877ec62cc92a495097dc9f954356dd442021-07-28T20:55:25ZengN.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare DepartmentTransplantologiâ2074-05062542-09092018-08-0103263210.23873/2074-0506-2012-0-3-26-32342Approaches to correction of immunosuppressive therapy in chronic nephrotoxicity of calcineurin inhibitorsE. S. Stolyarevich0J. G. Kim1L. Yu. Artyukhina2L. G. Kurenkova3N. D. Fedorova4N. A. Tomilin5FSI « Shumakov Scientific Centre of Transplantology and Artificial Organs»; Ministry of Health of the Russian Federation, MSMSUFSI « Shumakov Scientific Centre of Transplantology and Artificial Organs»; CCH № 52CCH № 52FSI « Shumakov Scientific Centre of Transplantology and Artificial Organs»FSI « Shumakov Scientific Centre of Transplantology and Artificial Organs»; CCH № 52FSI « Shumakov Scientific Centre of Transplantology and Artificial Organs»; Ministry of Health of the Russian Federation, MSMSU; CCH № 52Chronic nephrotoxicity of calcineurin inhibitors (CNI-nephrotoxicity) is one of the most common causes of kidney graft dysfunction requiring correction of maintenance immunosuppressive therapy.The aim of the study was to compare the efficacy and safety of the two possible approaches to dose adjustment of cyclosporine in patients with dysfunction of the transplanted kidney due to CNI-nephrotoxicity. It was established that the main cause of the abolition of Everolimus was proteinuria of nephrotic levels, developed in 19% of patients.https://www.jtransplantologiya.ru/jour/article/view/355kidney transplantationimmunosuppressive therapychronic nephrotoxicitycalcineurin inhibitorscyclosporine
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	E. S. Stolyarevich J. G. Kim L. Yu. Artyukhina L. G. Kurenkova N. D. Fedorova N. A. Tomilin
spellingShingle	E. S. Stolyarevich J. G. Kim L. Yu. Artyukhina L. G. Kurenkova N. D. Fedorova N. A. Tomilin Approaches to correction of immunosuppressive therapy in chronic nephrotoxicity of calcineurin inhibitors Transplantologiâ kidney transplantation immunosuppressive therapy chronic nephrotoxicity calcineurin inhibitors cyclosporine
author_facet	E. S. Stolyarevich J. G. Kim L. Yu. Artyukhina L. G. Kurenkova N. D. Fedorova N. A. Tomilin
author_sort	E. S. Stolyarevich
title	Approaches to correction of immunosuppressive therapy in chronic nephrotoxicity of calcineurin inhibitors
title_short	Approaches to correction of immunosuppressive therapy in chronic nephrotoxicity of calcineurin inhibitors
title_full	Approaches to correction of immunosuppressive therapy in chronic nephrotoxicity of calcineurin inhibitors
title_fullStr	Approaches to correction of immunosuppressive therapy in chronic nephrotoxicity of calcineurin inhibitors
title_full_unstemmed	Approaches to correction of immunosuppressive therapy in chronic nephrotoxicity of calcineurin inhibitors
title_sort	approaches to correction of immunosuppressive therapy in chronic nephrotoxicity of calcineurin inhibitors
publisher	N.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare Department
series	Transplantologiâ
issn	2074-0506 2542-0909
publishDate	2018-08-01
description	Chronic nephrotoxicity of calcineurin inhibitors (CNI-nephrotoxicity) is one of the most common causes of kidney graft dysfunction requiring correction of maintenance immunosuppressive therapy.The aim of the study was to compare the efficacy and safety of the two possible approaches to dose adjustment of cyclosporine in patients with dysfunction of the transplanted kidney due to CNI-nephrotoxicity. It was established that the main cause of the abolition of Everolimus was proteinuria of nephrotic levels, developed in 19% of patients.
topic	kidney transplantation immunosuppressive therapy chronic nephrotoxicity calcineurin inhibitors cyclosporine
url	https://www.jtransplantologiya.ru/jour/article/view/355
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Approaches to correction of immunosuppressive therapy in chronic nephrotoxicity of calcineurin inhibitors

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