Olfactory Stimulation Regulates the Birth of Neurons That Express Specific Odorant Receptors
Summary: In mammals, olfactory sensory neurons (OSNs) are born throughout life, ostensibly solely to replace damaged OSNs. During differentiation, each OSN precursor “chooses,” out of hundreds of possibilities, a single odorant receptor (OR) gene, which defines the identity of the mature OSN. The re...
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doaj-8787b270cba340538d4f4fb148afbbff2020-11-25T03:50:19ZengElsevierCell Reports2211-12472020-10-01331108210Olfactory Stimulation Regulates the Birth of Neurons That Express Specific Odorant ReceptorsCarl J. van der Linden0Pooja Gupta1Ashraful Islam Bhuiya2Kelci R. Riddick3Kawsar Hossain4Stephen W. Santoro5Department of Zoology & Physiology, University of Wyoming, Laramie, WY, USADepartment of Zoology & Physiology, University of Wyoming, Laramie, WY, USADepartment of Zoology & Physiology, University of Wyoming, Laramie, WY, USADepartment of Zoology & Physiology, University of Wyoming, Laramie, WY, USAMolecular and Cellular Life Sciences Program, University of Wyoming, Laramie, WY, USADepartment of Zoology & Physiology, University of Wyoming, Laramie, WY, USA; Corresponding authorSummary: In mammals, olfactory sensory neurons (OSNs) are born throughout life, ostensibly solely to replace damaged OSNs. During differentiation, each OSN precursor “chooses,” out of hundreds of possibilities, a single odorant receptor (OR) gene, which defines the identity of the mature OSN. The relative neurogenesis rates of the hundreds of distinct OSN “subtypes” are thought to be constant, as they are determined by a stochastic process in which each OR is chosen with a fixed probability. Here, using histological, single-cell, and targeted affinity purification approaches, we show that closing one nostril in mice selectively reduces the number of newly generated OSNs of specific subtypes. Moreover, these reductions depend on an animal’s age and/or environment. Stimulation-dependent changes in the number of new OSNs are not attributable to altered rates of cell survival but rather production. Our findings indicate that the relative birth rates of distinct OSN subtypes depend on olfactory experience.http://www.sciencedirect.com/science/article/pii/S2211124720311992olfactory sensory neuronsodorant receptorsneurogenesisodorant receptor gene choiceolfactory stimulationolfactory learning |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Carl J. van der Linden Pooja Gupta Ashraful Islam Bhuiya Kelci R. Riddick Kawsar Hossain Stephen W. Santoro |
spellingShingle |
Carl J. van der Linden Pooja Gupta Ashraful Islam Bhuiya Kelci R. Riddick Kawsar Hossain Stephen W. Santoro Olfactory Stimulation Regulates the Birth of Neurons That Express Specific Odorant Receptors Cell Reports olfactory sensory neurons odorant receptors neurogenesis odorant receptor gene choice olfactory stimulation olfactory learning |
author_facet |
Carl J. van der Linden Pooja Gupta Ashraful Islam Bhuiya Kelci R. Riddick Kawsar Hossain Stephen W. Santoro |
author_sort |
Carl J. van der Linden |
title |
Olfactory Stimulation Regulates the Birth of Neurons That Express Specific Odorant Receptors |
title_short |
Olfactory Stimulation Regulates the Birth of Neurons That Express Specific Odorant Receptors |
title_full |
Olfactory Stimulation Regulates the Birth of Neurons That Express Specific Odorant Receptors |
title_fullStr |
Olfactory Stimulation Regulates the Birth of Neurons That Express Specific Odorant Receptors |
title_full_unstemmed |
Olfactory Stimulation Regulates the Birth of Neurons That Express Specific Odorant Receptors |
title_sort |
olfactory stimulation regulates the birth of neurons that express specific odorant receptors |
publisher |
Elsevier |
series |
Cell Reports |
issn |
2211-1247 |
publishDate |
2020-10-01 |
description |
Summary: In mammals, olfactory sensory neurons (OSNs) are born throughout life, ostensibly solely to replace damaged OSNs. During differentiation, each OSN precursor “chooses,” out of hundreds of possibilities, a single odorant receptor (OR) gene, which defines the identity of the mature OSN. The relative neurogenesis rates of the hundreds of distinct OSN “subtypes” are thought to be constant, as they are determined by a stochastic process in which each OR is chosen with a fixed probability. Here, using histological, single-cell, and targeted affinity purification approaches, we show that closing one nostril in mice selectively reduces the number of newly generated OSNs of specific subtypes. Moreover, these reductions depend on an animal’s age and/or environment. Stimulation-dependent changes in the number of new OSNs are not attributable to altered rates of cell survival but rather production. Our findings indicate that the relative birth rates of distinct OSN subtypes depend on olfactory experience. |
topic |
olfactory sensory neurons odorant receptors neurogenesis odorant receptor gene choice olfactory stimulation olfactory learning |
url |
http://www.sciencedirect.com/science/article/pii/S2211124720311992 |
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