Knockdown of LRRN1 inhibits malignant phenotypes through the regulation of HIF-1α/Notch pathway in pancreatic ductal adenocarcinoma

Knockdown of LRRN1 inhibits malignant phenotypes through the regulation of HIF-1α/Notch pathway in pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is one of the most refractory and fatal human malignancies. Leucine-rich repeat neuronal protein-1 (LRRN1) plays a crucial role in the development of the nervous system. However, the clinical implications and biological functions of LRRN1 in PDAC remain unclea...

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Bibliographic Details
Main Authors: Yalu Zhang, Qiaofei Liu, Sen Yang, Quan Liao
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Molecular Therapy: Oncolytics
Subjects:
LRRN1
HIF-1α
proliferation
migration
invasion
pancreatic ductal adenocarcinoma
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770521001236

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