Conventional and Advanced Lipid Parameters in Premature Coronary Artery Disease Patients in India
Background: Coronary artery disease (CAD) is the leading cause of death worldwide and has assumed alarming proportions in India with gradual increase in its incidence and prevalence over the last decade. India is in the middle of epidemic of coronary artery disease which is leading cause of hosp...
Main Authors: | , , |
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Format: | Article |
Language: | English |
Published: |
JCDR Research and Publications Private Limited
2015-11-01
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Series: | Journal of Clinical and Diagnostic Research |
Subjects: | |
Online Access: | https://jcdr.net/articles/PDF/6844/14818_CE(RA1)_F(T)_PF1(BMAK)_PFA(P)_PF2(PAG).pdf |
Summary: | Background: Coronary artery disease (CAD) is the leading cause
of death worldwide and has assumed alarming proportions in India
with gradual increase in its incidence and prevalence over the
last decade. India is in the middle of epidemic of coronary artery
disease which is leading cause of hospital admissions, morbidity
and mortality. In the Indian population, there is higher tendency to
develop CAD at a younger age, which cannot be explained on the
basis of conventional lipid parameters.
Aim: The purpose of this study is to find advanced lipid parameters
which correlate better with premature CAD, as compared to the
conventional lipid parameters.
Materials and Methods: Thirty middle aged individuals suffering
from premature CAD and 30 age and gender matched healthy
individuals without any history of clinical evidence suggestive
of CAD were studied. Fasting venous blood samples of all the
subjects under study were collected after an overnight fasting
and conventional lipid parameters and advanced lipid parameters
(i.e. oxidized LDL, Lp (a), ApoA-1, small dense LDL, ApoB)
were estimated. Correlation of conventional and advanced lipid
parameters with premature CAD and among each other was
calculated using Pearson correlation coefficient.
Results: In our study the values of ox-LDL, sdLDL, Lp (a) and
ApoB, total cholesterol, TG, LDL-C were significantly higher while
HDL-C and Apo A1 and were significantly lower in cases than in
controls. Advanced lipid parameters have higher correlation with
premature CAD as compared to conventional lipid parameters. OxLDL show the highest correlation coefficient (r=+0.89) among these
parameters followed by Lp (a) (r=+0.86) and ApoB (r=+0.79).
Conclusion: Advanced lipid parameters (i.e. oxidized LDL, Lp
(a), ApoA-1, small dense LDL, ApoB) are better discriminator of
premature CAD as compared to conventional lipid parameters (total
cholesterol, triglycerides, low density lipoprotein and high density
lipoprotein). Oxidised LDL, small dense LDL and lipoprotein (a) can
explain occurrence of CAD in normolipidemic patients and proved
to be better markers for explaining high degree of prematurity,
morbidity and mortality of CAD in Indian population. They can
prove to be better marker for early detection and intervention in
premature CAD and site for targeted drug therapy. |
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ISSN: | 2249-782X 0973-709X |