Structure of the arginine methyltransferase PRMT5-MEP50 reveals a mechanism for substrate specificity.
The arginine methyltransferase PRMT5-MEP50 is required for embryogenesis and is misregulated in many cancers. PRMT5 targets a wide variety of substrates, including histone proteins involved in specifying an epigenetic code. However, the mechanism by which PRMT5 utilizes MEP50 to discriminate substra...
Main Authors: | Meng-Chiao Ho, Carola Wilczek, Jeffrey B Bonanno, Li Xing, Janina Seznec, Tsutomu Matsui, Lester G Carter, Takashi Onikubo, P Rajesh Kumar, Man K Chan, Michael Brenowitz, R Holland Cheng, Ulf Reimer, Steven C Almo, David Shechter |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2013-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3581573?pdf=render |
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