Data on hyper-activation of GPVI signalling in obese patients: Towards the identification of novel antiplatelet targets in obesity

Data on hyper-activation of GPVI signalling in obese patients: Towards the identification of novel antiplatelet targets in obesity

This data article is associated with the manuscript “GPVI surface expression and signalling pathway activation are increased in platelets from obese patients: elucidating potential anti-atherothrombotic targets in obesity” [1]. The study refers to a combination of different approaches in order to id...

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Main Authors: María N. Barrachina, Irene Izquierdo, Lidia Hermida-Nogueira, Aurelio M. Sueiro, Esteban Guitián, Felipe F. Casanueva, Richard W. Farndale, Masaaki Moroi, Stephanie M. Jung, María Pardo, Ángel García
Format: Article
Language:English
Published: Elsevier 2019-04-01
Series:Data in Brief
Online Access:http://www.sciencedirect.com/science/article/pii/S2352340919301350
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spelling doaj-879ea1a24be0403ea0dc486246a96d132020-11-25T01:52:43ZengElsevierData in Brief2352-34092019-04-0123Data on hyper-activation of GPVI signalling in obese patients: Towards the identification of novel antiplatelet targets in obesityMaría N. Barrachina0Irene Izquierdo1Lidia Hermida-Nogueira2Aurelio M. Sueiro3Esteban Guitián4Felipe F. Casanueva5Richard W. Farndale6Masaaki Moroi7Stephanie M. Jung8María Pardo9Ángel García10Platelet Proteomics Group, Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), Universidade Santiago de Compostela, Spain; Instituto de Investigación Sanitaria de Santiago (IDIS), SpainPlatelet Proteomics Group, Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), Universidade Santiago de Compostela, Spain; Instituto de Investigación Sanitaria de Santiago (IDIS), SpainPlatelet Proteomics Group, Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), Universidade Santiago de Compostela, Spain; Instituto de Investigación Sanitaria de Santiago (IDIS), SpainGrupo de Endocrinología Molecular y Celular, Instituto de Investigación Sanitaria de Santiago (IDIS)/ Servicio de Endocrinología, Xerencia de Xestión Integrada de Santiago (XXS), SpainMass Spectrometry and Proteomic Unit, Rede de Infraestructuras de Apoio á Investigación e ao Desenvolvemento Tecnolóxico, Universidade de Santiago de Compostela, Santiago de Compostela, SpainInstituto de Investigación Sanitaria de Santiago (IDIS), Spain; Grupo de Endocrinología Molecular y Celular, Instituto de Investigación Sanitaria de Santiago (IDIS)/ Servicio de Endocrinología, Xerencia de Xestión Integrada de Santiago (XXS), SpainDepartment of Biochemistry, University of Cambridge, Cambridge, CB2 1QW, United KingdomDepartment of Biochemistry, University of Cambridge, Cambridge, CB2 1QW, United KingdomDepartment of Biochemistry, University of Cambridge, Cambridge, CB2 1QW, United KingdomInstituto de Investigación Sanitaria de Santiago (IDIS), Spain; Grupo Obesidómica – Instituto de Investigación Sanitaria de Santiago (IDIS)Platelet Proteomics Group, Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), Universidade Santiago de Compostela, Spain; Instituto de Investigación Sanitaria de Santiago (IDIS), Spain; Corresponding author. Centro Singular de Investigación en Medicina Molecular y Enfermedades Crónicas (CIMUS), Universidade de Santiago de Compostela, Avda de Barcelona s/n, 15782, Santiago de Compostela, Spain.This data article is associated with the manuscript “GPVI surface expression and signalling pathway activation are increased in platelets from obese patients: elucidating potential anti-atherothrombotic targets in obesity” [1]. The study refers to a combination of different approaches in order to identify platelet-derived biomarkers in obesity. A total of 34 obese patients and their lean-matched controls were included in the study. We carried out a proteomic and functional (aggregation assays) analysis to find alterations in platelet-derived signalling pathways. After that, biochemical and mechanistic (flow cytometry assays) approaches were done in order to confirm a hyperactivation of the GPVI-related signalling pathway.http://www.sciencedirect.com/science/article/pii/S2352340919301350
collection DOAJ
language English
format Article
sources DOAJ
author María N. Barrachina
Irene Izquierdo
Lidia Hermida-Nogueira
Aurelio M. Sueiro
Esteban Guitián
Felipe F. Casanueva
Richard W. Farndale
Masaaki Moroi
Stephanie M. Jung
María Pardo
Ángel García
spellingShingle María N. Barrachina
Irene Izquierdo
Lidia Hermida-Nogueira
Aurelio M. Sueiro
Esteban Guitián
Felipe F. Casanueva
Richard W. Farndale
Masaaki Moroi
Stephanie M. Jung
María Pardo
Ángel García
Data on hyper-activation of GPVI signalling in obese patients: Towards the identification of novel antiplatelet targets in obesity
Data in Brief
author_facet María N. Barrachina
Irene Izquierdo
Lidia Hermida-Nogueira
Aurelio M. Sueiro
Esteban Guitián
Felipe F. Casanueva
Richard W. Farndale
Masaaki Moroi
Stephanie M. Jung
María Pardo
Ángel García
author_sort María N. Barrachina
title Data on hyper-activation of GPVI signalling in obese patients: Towards the identification of novel antiplatelet targets in obesity
title_short Data on hyper-activation of GPVI signalling in obese patients: Towards the identification of novel antiplatelet targets in obesity
title_full Data on hyper-activation of GPVI signalling in obese patients: Towards the identification of novel antiplatelet targets in obesity
title_fullStr Data on hyper-activation of GPVI signalling in obese patients: Towards the identification of novel antiplatelet targets in obesity
title_full_unstemmed Data on hyper-activation of GPVI signalling in obese patients: Towards the identification of novel antiplatelet targets in obesity
title_sort data on hyper-activation of gpvi signalling in obese patients: towards the identification of novel antiplatelet targets in obesity
publisher Elsevier
series Data in Brief
issn 2352-3409
publishDate 2019-04-01
description This data article is associated with the manuscript “GPVI surface expression and signalling pathway activation are increased in platelets from obese patients: elucidating potential anti-atherothrombotic targets in obesity” [1]. The study refers to a combination of different approaches in order to identify platelet-derived biomarkers in obesity. A total of 34 obese patients and their lean-matched controls were included in the study. We carried out a proteomic and functional (aggregation assays) analysis to find alterations in platelet-derived signalling pathways. After that, biochemical and mechanistic (flow cytometry assays) approaches were done in order to confirm a hyperactivation of the GPVI-related signalling pathway.
url http://www.sciencedirect.com/science/article/pii/S2352340919301350
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