Clinical outcome of patients with COVID-19 Pneumonia treated with corticosteroids and colchicine in Colombia
Abstract Background To date, there is no specific antiviral therapy for severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) that causes Coronavirus disease 2019 (Covid-19). Since there is no specific therapy against SARS-CoV2, current efforts aim to prevent contagion through public health m...
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doaj-87a14a0f0fd44125816af73f29e63a762021-09-19T11:14:12ZengBMCAnnals of Clinical Microbiology and Antimicrobials1476-07112021-09-0120111010.1186/s12941-021-00460-9Clinical outcome of patients with COVID-19 Pneumonia treated with corticosteroids and colchicine in ColombiaMiguel Alejandro Pinzón0Doris Cardona Arango1Juan Felipe Betancur2Santiago Ortiz3Héctor Holguín4Carolina Arias Arias5Bernardo J. Muñoz Palacio6Michael Amarillo7Juan Felipe Llano8Pablo Montoya9Infectious Diseases Department, Clínica Medellín Grupo Quirónsalud, Nueva Clínica Sagrado Corazón, Clínica PanamericanaCES UniversityInternal Medicine Department, Clínica Medellín Grupo Quirónsalud, Salud SURADepartment of Mathematical Sciences, Universidad EAFITClínica Medellín Grupo QuirónsaludCES UniversityPulmonology Department, Clínica Medellín Grupo QuirónsaludNueva Clínica Sagrado CorazónClínica Medellín Grupo QuirónsaludInternal Medicine Department, Nueva Clínica Sagrado CorazónAbstract Background To date, there is no specific antiviral therapy for severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) that causes Coronavirus disease 2019 (Covid-19). Since there is no specific therapy against SARS-CoV2, current efforts aim to prevent contagion through public health measures and develop a protective vaccine. While waiting for the latter, it is necessary to evaluate the drugs that at least, in initial studies, suggested some degree of utility in the management of Covid-19 or its complications. The main objective of the study was to describe the clinical manifestations and outcomes of patients with severe Covid-19 Pneumonia treated with corticosteroids and colchicine. Materials and methods A cross sectional study of 301 adult patients with Covid-19 Pneumonia confirmed by Real-Time Polymerase Chain Reaction for SARS-CoV2 (RT-PCR SARS-CoV2), Berlin protocol, who required hospitalization in three hospitals in Antioquia, Colombia. Patients were treated according to the institutional protocol (from March 20, 2020 to June 30, 2020) with corticosteroid if the patient required supplemental oxygen. From July 1, 2020, the management protocol changed with the addition of colchicine to all patients admitted to the institutions. The treatment was supervised and monitored by the same specialist in Infectology of the institutions. We describe the clinical manifestations and outcomes of the patients who received these treatments. The information of the patients was analyzed according to the outcome of interest (alive/dead) with univariate, bivariate, and multivariate measures to adjust the variables that presented statistical association. Results All patients had pneumonia documented by chest computed tomography with ground glass images and presented an alveolar pressure/inspired oxygen fraction (PaFi) less than 300. Three hundred one patients were included, 240 (79.7%) received corticosteroids, within these 145 (48.2%) received colchicine also, and the remaining 61 (20.3%) patients did not receive corticosterioids or colchicine. Mortality in the group that received colchicine was lower compared to the group that did not receive it (9.6 vs 14.6%, p-value = 0.179). Conclusions Treatment with corticosteroids and colchicine for managing patients with severe Covid-19 Pneumonia was associated with low mortality at the hospital level. Randomized, placebo-controlled studies are required to evaluate the effect of corticosteroids and colchicine on complications or death from Covid-19.https://doi.org/10.1186/s12941-021-00460-9CoronavirusCOVID-19ColchicineCorticosteroidsPneumonia |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Miguel Alejandro Pinzón Doris Cardona Arango Juan Felipe Betancur Santiago Ortiz Héctor Holguín Carolina Arias Arias Bernardo J. Muñoz Palacio Michael Amarillo Juan Felipe Llano Pablo Montoya |
spellingShingle |
Miguel Alejandro Pinzón Doris Cardona Arango Juan Felipe Betancur Santiago Ortiz Héctor Holguín Carolina Arias Arias Bernardo J. Muñoz Palacio Michael Amarillo Juan Felipe Llano Pablo Montoya Clinical outcome of patients with COVID-19 Pneumonia treated with corticosteroids and colchicine in Colombia Annals of Clinical Microbiology and Antimicrobials Coronavirus COVID-19 Colchicine Corticosteroids Pneumonia |
author_facet |
Miguel Alejandro Pinzón Doris Cardona Arango Juan Felipe Betancur Santiago Ortiz Héctor Holguín Carolina Arias Arias Bernardo J. Muñoz Palacio Michael Amarillo Juan Felipe Llano Pablo Montoya |
author_sort |
Miguel Alejandro Pinzón |
title |
Clinical outcome of patients with COVID-19 Pneumonia treated with corticosteroids and colchicine in Colombia |
title_short |
Clinical outcome of patients with COVID-19 Pneumonia treated with corticosteroids and colchicine in Colombia |
title_full |
Clinical outcome of patients with COVID-19 Pneumonia treated with corticosteroids and colchicine in Colombia |
title_fullStr |
Clinical outcome of patients with COVID-19 Pneumonia treated with corticosteroids and colchicine in Colombia |
title_full_unstemmed |
Clinical outcome of patients with COVID-19 Pneumonia treated with corticosteroids and colchicine in Colombia |
title_sort |
clinical outcome of patients with covid-19 pneumonia treated with corticosteroids and colchicine in colombia |
publisher |
BMC |
series |
Annals of Clinical Microbiology and Antimicrobials |
issn |
1476-0711 |
publishDate |
2021-09-01 |
description |
Abstract Background To date, there is no specific antiviral therapy for severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) that causes Coronavirus disease 2019 (Covid-19). Since there is no specific therapy against SARS-CoV2, current efforts aim to prevent contagion through public health measures and develop a protective vaccine. While waiting for the latter, it is necessary to evaluate the drugs that at least, in initial studies, suggested some degree of utility in the management of Covid-19 or its complications. The main objective of the study was to describe the clinical manifestations and outcomes of patients with severe Covid-19 Pneumonia treated with corticosteroids and colchicine. Materials and methods A cross sectional study of 301 adult patients with Covid-19 Pneumonia confirmed by Real-Time Polymerase Chain Reaction for SARS-CoV2 (RT-PCR SARS-CoV2), Berlin protocol, who required hospitalization in three hospitals in Antioquia, Colombia. Patients were treated according to the institutional protocol (from March 20, 2020 to June 30, 2020) with corticosteroid if the patient required supplemental oxygen. From July 1, 2020, the management protocol changed with the addition of colchicine to all patients admitted to the institutions. The treatment was supervised and monitored by the same specialist in Infectology of the institutions. We describe the clinical manifestations and outcomes of the patients who received these treatments. The information of the patients was analyzed according to the outcome of interest (alive/dead) with univariate, bivariate, and multivariate measures to adjust the variables that presented statistical association. Results All patients had pneumonia documented by chest computed tomography with ground glass images and presented an alveolar pressure/inspired oxygen fraction (PaFi) less than 300. Three hundred one patients were included, 240 (79.7%) received corticosteroids, within these 145 (48.2%) received colchicine also, and the remaining 61 (20.3%) patients did not receive corticosterioids or colchicine. Mortality in the group that received colchicine was lower compared to the group that did not receive it (9.6 vs 14.6%, p-value = 0.179). Conclusions Treatment with corticosteroids and colchicine for managing patients with severe Covid-19 Pneumonia was associated with low mortality at the hospital level. Randomized, placebo-controlled studies are required to evaluate the effect of corticosteroids and colchicine on complications or death from Covid-19. |
topic |
Coronavirus COVID-19 Colchicine Corticosteroids Pneumonia |
url |
https://doi.org/10.1186/s12941-021-00460-9 |
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