Schistosoma mansoni: control of female fertility by the male
We have established an in vitro culture system for adult schistosomes that allows monitoring gene expression for up to more than ten days. Comparing female worms that are paired with those that have been separated, we find distinct differences, clearly documenting an influence of the male in female...
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Instituto Oswaldo Cruz, Ministério da Saúde
1995-04-01
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Series: | Memórias do Instituto Oswaldo Cruz. |
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Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761995000200010 |
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doaj-87a2d274cd69490ebf7c69e6b650cb5b2020-11-24T23:23:17ZengInstituto Oswaldo Cruz, Ministério da SaúdeMemórias do Instituto Oswaldo Cruz.0074-02761678-80601995-04-0190218518910.1590/S0074-02761995000200010Schistosoma mansoni: control of female fertility by the maleWerner KunzLutz GohrChristoph GreveldingPeter SchüsslerGabriele SommerMarion MenrathAnja MichelWe have established an in vitro culture system for adult schistosomes that allows monitoring gene expression for up to more than ten days. Comparing female worms that are paired with those that have been separated, we find distinct differences, clearly documenting an influence of the male in female gene expression. In perfect coincidence with classical observations that were based on histological techniques, we find that the male particularly regulates gene expression in those tissues that are characterized by cell proliferation, e.g. the vitellaria. From these results, we hypothesize that the key target for the inductive signal that is transferred from the male to the female during pairing is the activation of a growth factor that stimulates mitotic proliferation.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761995000200010Schistosoma mansoniin vitro culturegene expressionmalefemale interaction |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Werner Kunz Lutz Gohr Christoph Grevelding Peter Schüssler Gabriele Sommer Marion Menrath Anja Michel |
spellingShingle |
Werner Kunz Lutz Gohr Christoph Grevelding Peter Schüssler Gabriele Sommer Marion Menrath Anja Michel Schistosoma mansoni: control of female fertility by the male Memórias do Instituto Oswaldo Cruz. Schistosoma mansoni in vitro culture gene expression male female interaction |
author_facet |
Werner Kunz Lutz Gohr Christoph Grevelding Peter Schüssler Gabriele Sommer Marion Menrath Anja Michel |
author_sort |
Werner Kunz |
title |
Schistosoma mansoni: control of female fertility by the male |
title_short |
Schistosoma mansoni: control of female fertility by the male |
title_full |
Schistosoma mansoni: control of female fertility by the male |
title_fullStr |
Schistosoma mansoni: control of female fertility by the male |
title_full_unstemmed |
Schistosoma mansoni: control of female fertility by the male |
title_sort |
schistosoma mansoni: control of female fertility by the male |
publisher |
Instituto Oswaldo Cruz, Ministério da Saúde |
series |
Memórias do Instituto Oswaldo Cruz. |
issn |
0074-0276 1678-8060 |
publishDate |
1995-04-01 |
description |
We have established an in vitro culture system for adult schistosomes that allows monitoring gene expression for up to more than ten days. Comparing female worms that are paired with those that have been separated, we find distinct differences, clearly documenting an influence of the male in female gene expression. In perfect coincidence with classical observations that were based on histological techniques, we find that the male particularly regulates gene expression in those tissues that are characterized by cell proliferation, e.g. the vitellaria. From these results, we hypothesize that the key target for the inductive signal that is transferred from the male to the female during pairing is the activation of a growth factor that stimulates mitotic proliferation. |
topic |
Schistosoma mansoni in vitro culture gene expression male female interaction |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761995000200010 |
work_keys_str_mv |
AT wernerkunz schistosomamansonicontroloffemalefertilitybythemale AT lutzgohr schistosomamansonicontroloffemalefertilitybythemale AT christophgrevelding schistosomamansonicontroloffemalefertilitybythemale AT peterschussler schistosomamansonicontroloffemalefertilitybythemale AT gabrielesommer schistosomamansonicontroloffemalefertilitybythemale AT marionmenrath schistosomamansonicontroloffemalefertilitybythemale AT anjamichel schistosomamansonicontroloffemalefertilitybythemale |
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