A mathematical modelling tool for unravelling the antibody-mediated effects on CTLA-4 interactions

A mathematical modelling tool for unravelling the antibody-mediated effects on CTLA-4 interactions

Abstract Background Monoclonal antibodies blocking the Cytotoxic T-lymphocyte antigen 4 (CTLA-4) receptor have revolutionized the field of anti-cancer therapy for the last few years. The human T-cell-based immune responses are modulated by two contradicting signals. CTLA-4 provides a T cell inhibito...

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Bibliographic Details
Main Authors: Aravindhan Ganesan, Theinmozhi Arulraj, Tahir Choulli, Khaled H. Barakat
Format: Article
Language:English
Published: BMC 2018-06-01
Series:BMC Medical Informatics and Decision Making
Subjects:
CTLA-4
Immune checkpoints
Ipilimumab
Tremelimumab
Antibody
Mathematical modeling
Online Access:http://link.springer.com/article/10.1186/s12911-018-0606-x

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http://link.springer.com/article/10.1186/s12911-018-0606-x

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