Immunomodulatory Effects of Dietary Polyphenols
Functional and nutraceutical foods provide an alternative way to improve immune function to aid in the management of various diseases. Traditionally, many medicinal products have been derived from natural compounds with healing properties. With the development of research into nutraceuticals, it is...
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doaj-87aa66adcfdd4e7aa564da382bf5d8272021-02-26T00:02:19ZengMDPI AGNutrients2072-66432021-02-011372872810.3390/nu13030728Immunomodulatory Effects of Dietary PolyphenolsHira Shakoor0Jack Feehan1Vasso Apostolopoulos2Carine Platat3Ayesha Salem Al Dhaheri4Habiba I. Ali5Leila Cheikh Ismail6Marijan Bosevski7Lily Stojanovska8Department of Nutrition and Health, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain 15551, United Arab EmiratesInstitute for Health and Sport, Victoria University, Melbourne 3011, AustraliaInstitute for Health and Sport, Victoria University, Melbourne 3011, AustraliaDepartment of Nutrition and Health, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain 15551, United Arab EmiratesDepartment of Nutrition and Health, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain 15551, United Arab EmiratesDepartment of Nutrition and Health, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain 15551, United Arab EmiratesClinical Nutrition and Dietetics Department, College of Health Sciences, Research Institute of Medical and Health Sciences (RIMHS), University of Sharjah, Sharjah 27272, United Arab EmiratesSt. Cyril and Methodius Faculty of Medicine, University Cardiology Clinic, 1000 Skopje, North MacedoniaDepartment of Nutrition and Health, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain 15551, United Arab EmiratesFunctional and nutraceutical foods provide an alternative way to improve immune function to aid in the management of various diseases. Traditionally, many medicinal products have been derived from natural compounds with healing properties. With the development of research into nutraceuticals, it is becoming apparent that many of the beneficial properties of these compounds are at least partly due to the presence of polyphenols. There is evidence that dietary polyphenols can influence dendritic cells, have an immunomodulatory effect on macrophages, increase proliferation of B cells, T cells and suppress Type 1 T helper (Th1), Th2, Th17 and Th9 cells. Polyphenols reduce inflammation by suppressing the pro-inflammatory cytokines in inflammatory bowel disease by inducing Treg cells in the intestine, inhibition of tumor necrosis factor-alpha (TNF-α) and induction of apoptosis, decreasing DNA damage. Polyphenols have a potential role in prevention/treatment of auto-immune diseases like type 1 diabetes, rheumatoid arthritis and multiple sclerosis by regulating signaling pathways, suppressing inflammation and limiting demyelination. In addition, polyphenols cause immunomodulatory effects against allergic reaction and autoimmune disease by inhibition of autoimmune T cell proliferation and downregulation of pro-inflammatory cytokines (interleukin-6 (IL-6), IL-1, interferon-γ (IFN-γ)). Herein, we summarize the immunomodulatory effects of polyphenols and the underlying mechanisms involved in the stimulation of immune responses.https://www.mdpi.com/2072-6643/13/3/728polyphenolsimmunomodulationpro-inflammatory cytokinesanti-inflammatory cytokines |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hira Shakoor Jack Feehan Vasso Apostolopoulos Carine Platat Ayesha Salem Al Dhaheri Habiba I. Ali Leila Cheikh Ismail Marijan Bosevski Lily Stojanovska |
spellingShingle |
Hira Shakoor Jack Feehan Vasso Apostolopoulos Carine Platat Ayesha Salem Al Dhaheri Habiba I. Ali Leila Cheikh Ismail Marijan Bosevski Lily Stojanovska Immunomodulatory Effects of Dietary Polyphenols Nutrients polyphenols immunomodulation pro-inflammatory cytokines anti-inflammatory cytokines |
author_facet |
Hira Shakoor Jack Feehan Vasso Apostolopoulos Carine Platat Ayesha Salem Al Dhaheri Habiba I. Ali Leila Cheikh Ismail Marijan Bosevski Lily Stojanovska |
author_sort |
Hira Shakoor |
title |
Immunomodulatory Effects of Dietary Polyphenols |
title_short |
Immunomodulatory Effects of Dietary Polyphenols |
title_full |
Immunomodulatory Effects of Dietary Polyphenols |
title_fullStr |
Immunomodulatory Effects of Dietary Polyphenols |
title_full_unstemmed |
Immunomodulatory Effects of Dietary Polyphenols |
title_sort |
immunomodulatory effects of dietary polyphenols |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2021-02-01 |
description |
Functional and nutraceutical foods provide an alternative way to improve immune function to aid in the management of various diseases. Traditionally, many medicinal products have been derived from natural compounds with healing properties. With the development of research into nutraceuticals, it is becoming apparent that many of the beneficial properties of these compounds are at least partly due to the presence of polyphenols. There is evidence that dietary polyphenols can influence dendritic cells, have an immunomodulatory effect on macrophages, increase proliferation of B cells, T cells and suppress Type 1 T helper (Th1), Th2, Th17 and Th9 cells. Polyphenols reduce inflammation by suppressing the pro-inflammatory cytokines in inflammatory bowel disease by inducing Treg cells in the intestine, inhibition of tumor necrosis factor-alpha (TNF-α) and induction of apoptosis, decreasing DNA damage. Polyphenols have a potential role in prevention/treatment of auto-immune diseases like type 1 diabetes, rheumatoid arthritis and multiple sclerosis by regulating signaling pathways, suppressing inflammation and limiting demyelination. In addition, polyphenols cause immunomodulatory effects against allergic reaction and autoimmune disease by inhibition of autoimmune T cell proliferation and downregulation of pro-inflammatory cytokines (interleukin-6 (IL-6), IL-1, interferon-γ (IFN-γ)). Herein, we summarize the immunomodulatory effects of polyphenols and the underlying mechanisms involved in the stimulation of immune responses. |
topic |
polyphenols immunomodulation pro-inflammatory cytokines anti-inflammatory cytokines |
url |
https://www.mdpi.com/2072-6643/13/3/728 |
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