Benzodiazepines Reduce Relapse and Recurrence Rates in Patients with Psychotic Depression
The long-term use of benzodiazepines is not recommended for the treatment of major depressive disorder (MDD) due to the risk of adverse effects, including dependence, falls, dementia, mortality and the lack of evidence of effectiveness for symptoms other than anxiety. However, there are many patient...
Main Authors: | , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-06-01
|
Series: | Journal of Clinical Medicine |
Subjects: | |
Online Access: | https://www.mdpi.com/2077-0383/9/6/1938 |
id |
doaj-87ad37c22686407a96db2700407b27cd |
---|---|
record_format |
Article |
spelling |
doaj-87ad37c22686407a96db2700407b27cd2020-11-25T03:20:08ZengMDPI AGJournal of Clinical Medicine2077-03832020-06-0191938193810.3390/jcm9061938Benzodiazepines Reduce Relapse and Recurrence Rates in Patients with Psychotic DepressionHiroki Shiwaku0Masako Fujita1Hidehiko Takahashi2Department of Psychiatry and Behavioral Sciences, Tokyo Medical and Dental University Graduate School, 1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8519, JapanDepartment of Psychiatry and Behavioral Sciences, Tokyo Medical and Dental University Graduate School, 1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8519, JapanDepartment of Psychiatry and Behavioral Sciences, Tokyo Medical and Dental University Graduate School, 1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8519, JapanThe long-term use of benzodiazepines is not recommended for the treatment of major depressive disorder (MDD) due to the risk of adverse effects, including dependence, falls, dementia, mortality and the lack of evidence of effectiveness for symptoms other than anxiety. However, there are many patients with MDD for whom antidepressants are co-administrated with benzodiazepines. This study aimed to identify whether the use of benzodiazepines is associated with a lower risk of relapse or recurrence of MDD in some patients, and the characteristics of these patients. Kaplan–Meier survival analysis was used to quantify the relapse and recurrence of MDD in 108 patients with MDD who achieved remission during hospitalization. Among them, 26 patients had been diagnosed with severe MDD with psychotic features. There was no significant difference in the rate of relapse/recurrence between patients with and without benzodiazepines when all patients were analyzed together. However, among the 26 patients with psychotic depression, 21.2% in the benzodiazepine group and 75.0% in the non-benzodiazepine group experienced relapse (log rank <i>p</i> = 0.0040). Kaplan–Meier survival analysis revealed that this effect was dose-dependent. The adjunctive use of benzodiazepines may reduce relapse/recurrence rates in patients with severe MDD with psychotic features.https://www.mdpi.com/2077-0383/9/6/1938major depressive disorderbenzodiazepinesrelapserecurrence |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hiroki Shiwaku Masako Fujita Hidehiko Takahashi |
spellingShingle |
Hiroki Shiwaku Masako Fujita Hidehiko Takahashi Benzodiazepines Reduce Relapse and Recurrence Rates in Patients with Psychotic Depression Journal of Clinical Medicine major depressive disorder benzodiazepines relapse recurrence |
author_facet |
Hiroki Shiwaku Masako Fujita Hidehiko Takahashi |
author_sort |
Hiroki Shiwaku |
title |
Benzodiazepines Reduce Relapse and Recurrence Rates in Patients with Psychotic Depression |
title_short |
Benzodiazepines Reduce Relapse and Recurrence Rates in Patients with Psychotic Depression |
title_full |
Benzodiazepines Reduce Relapse and Recurrence Rates in Patients with Psychotic Depression |
title_fullStr |
Benzodiazepines Reduce Relapse and Recurrence Rates in Patients with Psychotic Depression |
title_full_unstemmed |
Benzodiazepines Reduce Relapse and Recurrence Rates in Patients with Psychotic Depression |
title_sort |
benzodiazepines reduce relapse and recurrence rates in patients with psychotic depression |
publisher |
MDPI AG |
series |
Journal of Clinical Medicine |
issn |
2077-0383 |
publishDate |
2020-06-01 |
description |
The long-term use of benzodiazepines is not recommended for the treatment of major depressive disorder (MDD) due to the risk of adverse effects, including dependence, falls, dementia, mortality and the lack of evidence of effectiveness for symptoms other than anxiety. However, there are many patients with MDD for whom antidepressants are co-administrated with benzodiazepines. This study aimed to identify whether the use of benzodiazepines is associated with a lower risk of relapse or recurrence of MDD in some patients, and the characteristics of these patients. Kaplan–Meier survival analysis was used to quantify the relapse and recurrence of MDD in 108 patients with MDD who achieved remission during hospitalization. Among them, 26 patients had been diagnosed with severe MDD with psychotic features. There was no significant difference in the rate of relapse/recurrence between patients with and without benzodiazepines when all patients were analyzed together. However, among the 26 patients with psychotic depression, 21.2% in the benzodiazepine group and 75.0% in the non-benzodiazepine group experienced relapse (log rank <i>p</i> = 0.0040). Kaplan–Meier survival analysis revealed that this effect was dose-dependent. The adjunctive use of benzodiazepines may reduce relapse/recurrence rates in patients with severe MDD with psychotic features. |
topic |
major depressive disorder benzodiazepines relapse recurrence |
url |
https://www.mdpi.com/2077-0383/9/6/1938 |
work_keys_str_mv |
AT hirokishiwaku benzodiazepinesreducerelapseandrecurrenceratesinpatientswithpsychoticdepression AT masakofujita benzodiazepinesreducerelapseandrecurrenceratesinpatientswithpsychoticdepression AT hidehikotakahashi benzodiazepinesreducerelapseandrecurrenceratesinpatientswithpsychoticdepression |
_version_ |
1724619223449206784 |