Comparison of efficacy of conventional nonmodified-release minocycline and newer extended-release minocycline in treatment of acne vulgaris

• Main Authors: Vidyadhar R Sardesai, Ruhi R Uttamani
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2018-01-01
• Series: Indian Journal of Drugs in Dermatology
• Subjects: Acne vulgaris; conventional; extended release; minocycline
• Online Access: http://www.ijdd.in/article.asp?issn=2455-3972;year=2018;volume=4;issue=2;spage=57;epage=60;aulast=Sardesai
• ISSN: 2455-3972; 2455-3972

Aims: The aim is to study the efficacy of conventional and extended-release minocycline therapy in acne vulgaris and to compare the two regimens for the efficacy and side effects. Materials and Methods: An open, randomized, comparative, prospective study was conducted on forty newly diagnosed cases of acne vulgaris (Grades 2 and 3) with more than 15 lesions. Patients were randomly allotted into one of the two groups which received extended-release minocycline and conventional minocycline, respectively, for 3 weeks. Both groups were prescribed local application of benzoyl peroxide 2.5% at night. All the patients were evaluated at the end of 3 weeks using paired and unpaired t-test. Results: Improvement was noted in patients belonging to both the groups. When both the groups were compared statistically using unpaired t-test, extended-release minocycline was significantly better in the treatment of inflammatory papules. Conclusions: Both conventional minocycline and extended-release minocycline were effective in the treatment of moderate and moderately severe acne vulgaris. Statistically inflammatory lesions respond better to extended-release minocycline.