Study protocol: ASCRIBED: the impact of Acute SystematiC inflammation upon cerebRospinal fluId and blood BiomarkErs of brain inflammation and injury in dementia: a study in acute hip fracture patients
Abstract Background Hip fracture represents a substantial acute inflammatory trauma, which may constitute a significant insult to the degenerating brain. Research suggests that an injury of this kind can affect memory and thinking in the future but it is unclear whether, and how, inflammatory trauma...
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BMC
2019-09-01
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Series: | BMC Neurology |
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Online Access: | http://link.springer.com/article/10.1186/s12883-019-1447-7 |
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Article |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nick Leavey Simon P. Hammond Lee Shepstone Jane Cross Henrik Zetterberg Colm Cunningham Alasdair MacLullich Leiv Otto Watne Anne Marie Minihane Clive Ballard Anne-Brita Knapskog Roanna Hall Gregory Howard Matt Hammond Chris Fox |
spellingShingle |
Nick Leavey Simon P. Hammond Lee Shepstone Jane Cross Henrik Zetterberg Colm Cunningham Alasdair MacLullich Leiv Otto Watne Anne Marie Minihane Clive Ballard Anne-Brita Knapskog Roanna Hall Gregory Howard Matt Hammond Chris Fox Study protocol: ASCRIBED: the impact of Acute SystematiC inflammation upon cerebRospinal fluId and blood BiomarkErs of brain inflammation and injury in dementia: a study in acute hip fracture patients BMC Neurology Dementia Hip fracture Inflammation Cerebrospinal fluid |
author_facet |
Nick Leavey Simon P. Hammond Lee Shepstone Jane Cross Henrik Zetterberg Colm Cunningham Alasdair MacLullich Leiv Otto Watne Anne Marie Minihane Clive Ballard Anne-Brita Knapskog Roanna Hall Gregory Howard Matt Hammond Chris Fox |
author_sort |
Nick Leavey |
title |
Study protocol: ASCRIBED: the impact of Acute SystematiC inflammation upon cerebRospinal fluId and blood BiomarkErs of brain inflammation and injury in dementia: a study in acute hip fracture patients |
title_short |
Study protocol: ASCRIBED: the impact of Acute SystematiC inflammation upon cerebRospinal fluId and blood BiomarkErs of brain inflammation and injury in dementia: a study in acute hip fracture patients |
title_full |
Study protocol: ASCRIBED: the impact of Acute SystematiC inflammation upon cerebRospinal fluId and blood BiomarkErs of brain inflammation and injury in dementia: a study in acute hip fracture patients |
title_fullStr |
Study protocol: ASCRIBED: the impact of Acute SystematiC inflammation upon cerebRospinal fluId and blood BiomarkErs of brain inflammation and injury in dementia: a study in acute hip fracture patients |
title_full_unstemmed |
Study protocol: ASCRIBED: the impact of Acute SystematiC inflammation upon cerebRospinal fluId and blood BiomarkErs of brain inflammation and injury in dementia: a study in acute hip fracture patients |
title_sort |
study protocol: ascribed: the impact of acute systematic inflammation upon cerebrospinal fluid and blood biomarkers of brain inflammation and injury in dementia: a study in acute hip fracture patients |
publisher |
BMC |
series |
BMC Neurology |
issn |
1471-2377 |
publishDate |
2019-09-01 |
description |
Abstract Background Hip fracture represents a substantial acute inflammatory trauma, which may constitute a significant insult to the degenerating brain. Research suggests that an injury of this kind can affect memory and thinking in the future but it is unclear whether, and how, inflammatory trauma injures the brain. The impact of Acute SystematiC inflammation upon cerebRospinal fluId and blood BiomarkErs of brain inflammation and injury in Dementia: a study in acute hip fracture patients (ASCRIBED) explores this relationship, to understand the effect of inflammation on the progression of dementia. Methods This protocol describes a multi-centre sample collection observational study. The study utilises the unique opportunity provided by hip fracture operations undertaken via spinal anaesthesia to collect cerebrospinal fluid (CSF) and blood, to investigate the impact of acute brain inflammation caused by hip fracture on the exacerbation of dementia. We will recruit 200 hip fracture patients with a diagnosis or evidence of dementia; and 200 hip fracture patients without dementia. We will also recruit ‘Suitable informants’, individuals in regular contact with the patient, to provide further proxy evidence of a patient’s potential cognitive decline. We will compare these 400 samples with existing CSF and blood samples from a cohort of dementia patients who had not experienced a systemic inflammatory response due to injury. This will provide a comparison between patients with and without dementia who are suffering a systemic inflammatory response; with stable patients living with dementia. Discussion We will test the hypothesis that hip fracture patients living with dementia show elevated markers of brain inflammation, as well as neuronal injury and Alzheimer-related plaque pathology, in comparison to (1) stable patients living with dementia and (2) hip fracture patients without dementia, as measured by biomarkers in CSF and blood. The findings will address the hypothesis that systemic inflammatory events can exacerbate underlying dementia and inform the search for new treatments targeting inflammation in dementia. Trial registration ISRCTN43803769. Registered 11 May 2017. |
topic |
Dementia Hip fracture Inflammation Cerebrospinal fluid |
url |
http://link.springer.com/article/10.1186/s12883-019-1447-7 |
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doaj-87cc5115c9cb455c97ec6b4fbc5a76ae2020-11-25T03:24:55ZengBMCBMC Neurology1471-23772019-09-0119111110.1186/s12883-019-1447-7Study protocol: ASCRIBED: the impact of Acute SystematiC inflammation upon cerebRospinal fluId and blood BiomarkErs of brain inflammation and injury in dementia: a study in acute hip fracture patientsNick Leavey0Simon P. Hammond1Lee Shepstone2Jane Cross3Henrik Zetterberg4Colm Cunningham5Alasdair MacLullich6Leiv Otto Watne7Anne Marie Minihane8Clive Ballard9Anne-Brita Knapskog10Roanna Hall11Gregory Howard12Matt Hammond13Chris Fox14Norwich Clinical Trial Unit, Norwich Medical School, Faculty of Medicine and Health Sciences, University of East AngliaSchool of Education and Lifelong Learning, Faculty of Social Sciences, University of East AngliaNorwich Medical School, Faculty of Medicine and Health Sciences, University of East AngliaSchool of Health Sciences, Faculty of Medicine and Health Sciences, University of East AngliaDepartment of Psychiatry and Neurochemistry, the Sahlgrenska Academy at the University of GothenburgSchool of Biochemistry and Immunology, Trinity Biomedical Sciences Institute & Trinity College Institute of Neuroscience, Trinity College DublinEdinburgh Delirium Rese arch Group, Geriatric Medicine, University of Edinburgh, Royal Infirmary EdinburghOslo Delirium Research Group, Department of Geriatric Medicine, Oslo University HospitalNorwich Medical School, BCRE, James Watson Road, University of East AngliaWolfson Centre for Age Related Diseases, King’s College London Guy’s CampusDepartment of Geriatric Medicine, Oslo University HospitalDepartment of Geriatric Medicine, University of Edinburgh Room S1642, New Royal Infirmary of EdinburghNorwich Clinical Trial Unit, Norwich Medical School, Faculty of Medicine and Health Sciences, University of East AngliaNorwich Clinical Trial Unit, Norwich Medical School, Faculty of Medicine and Health Sciences, University of East AngliaDepartment of Psychological Sciences, Norwich Medical School, Faculty of Medicine and Health Sciences, University of East AngliaAbstract Background Hip fracture represents a substantial acute inflammatory trauma, which may constitute a significant insult to the degenerating brain. Research suggests that an injury of this kind can affect memory and thinking in the future but it is unclear whether, and how, inflammatory trauma injures the brain. The impact of Acute SystematiC inflammation upon cerebRospinal fluId and blood BiomarkErs of brain inflammation and injury in Dementia: a study in acute hip fracture patients (ASCRIBED) explores this relationship, to understand the effect of inflammation on the progression of dementia. Methods This protocol describes a multi-centre sample collection observational study. The study utilises the unique opportunity provided by hip fracture operations undertaken via spinal anaesthesia to collect cerebrospinal fluid (CSF) and blood, to investigate the impact of acute brain inflammation caused by hip fracture on the exacerbation of dementia. We will recruit 200 hip fracture patients with a diagnosis or evidence of dementia; and 200 hip fracture patients without dementia. We will also recruit ‘Suitable informants’, individuals in regular contact with the patient, to provide further proxy evidence of a patient’s potential cognitive decline. We will compare these 400 samples with existing CSF and blood samples from a cohort of dementia patients who had not experienced a systemic inflammatory response due to injury. This will provide a comparison between patients with and without dementia who are suffering a systemic inflammatory response; with stable patients living with dementia. Discussion We will test the hypothesis that hip fracture patients living with dementia show elevated markers of brain inflammation, as well as neuronal injury and Alzheimer-related plaque pathology, in comparison to (1) stable patients living with dementia and (2) hip fracture patients without dementia, as measured by biomarkers in CSF and blood. The findings will address the hypothesis that systemic inflammatory events can exacerbate underlying dementia and inform the search for new treatments targeting inflammation in dementia. Trial registration ISRCTN43803769. Registered 11 May 2017.http://link.springer.com/article/10.1186/s12883-019-1447-7DementiaHip fractureInflammationCerebrospinal fluid |