Prospective In Vitro Models of Channelopathies and Cardiomyopathies
An in vitro heart disease model is a promising model used for identifying the genes responsible for the disease, evaluating the effects of drugs, and regenerative medicine. We were interested in disease models using a patient-induced pluripotent stem (iPS) cell-derived cardiomyocytes because of thei...
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2012-01-01
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Series: | Stem Cells International |
Online Access: | http://dx.doi.org/10.1155/2012/439219 |
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doaj-87cc5400ccad402e95f07e01e2f451f02020-11-24T21:00:24ZengHindawi LimitedStem Cells International1687-966X1687-96782012-01-01201210.1155/2012/439219439219Prospective In Vitro Models of Channelopathies and CardiomyopathiesNanako Kawaguchi0Emiko Hayama1Yoshiyuki Furutani2Toshio Nakanishi3Department of Pediatric Cardiology, Tokyo Women’s Medical University, 8-1, Kawada-cho, Shinjuku-ku, Tokyo 162-8666, JapanDepartment of Pediatric Cardiology, Tokyo Women’s Medical University, 8-1, Kawada-cho, Shinjuku-ku, Tokyo 162-8666, JapanDepartment of Pediatric Cardiology, Tokyo Women’s Medical University, 8-1, Kawada-cho, Shinjuku-ku, Tokyo 162-8666, JapanDepartment of Pediatric Cardiology, Tokyo Women’s Medical University, 8-1, Kawada-cho, Shinjuku-ku, Tokyo 162-8666, JapanAn in vitro heart disease model is a promising model used for identifying the genes responsible for the disease, evaluating the effects of drugs, and regenerative medicine. We were interested in disease models using a patient-induced pluripotent stem (iPS) cell-derived cardiomyocytes because of their similarity to a patient’s tissues. However, as these studies have just begun, we would like to review the literature in this and other related fields and discuss the path for future models of molecular biology that can help to diagnose and cure diseases, and its involvement in regenerative medicine. The heterogeneity of iPS cells and/or differentiated cardiomyocytes has been recognized as a problem. An in vitro heart disease model should be evaluated using molecular biological analyses, such as mRNA and micro-RNA expression profiles and proteomic analysis.http://dx.doi.org/10.1155/2012/439219 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nanako Kawaguchi Emiko Hayama Yoshiyuki Furutani Toshio Nakanishi |
spellingShingle |
Nanako Kawaguchi Emiko Hayama Yoshiyuki Furutani Toshio Nakanishi Prospective In Vitro Models of Channelopathies and Cardiomyopathies Stem Cells International |
author_facet |
Nanako Kawaguchi Emiko Hayama Yoshiyuki Furutani Toshio Nakanishi |
author_sort |
Nanako Kawaguchi |
title |
Prospective In Vitro Models of Channelopathies and Cardiomyopathies |
title_short |
Prospective In Vitro Models of Channelopathies and Cardiomyopathies |
title_full |
Prospective In Vitro Models of Channelopathies and Cardiomyopathies |
title_fullStr |
Prospective In Vitro Models of Channelopathies and Cardiomyopathies |
title_full_unstemmed |
Prospective In Vitro Models of Channelopathies and Cardiomyopathies |
title_sort |
prospective in vitro models of channelopathies and cardiomyopathies |
publisher |
Hindawi Limited |
series |
Stem Cells International |
issn |
1687-966X 1687-9678 |
publishDate |
2012-01-01 |
description |
An in vitro heart disease model is a promising model used for identifying the genes responsible for the disease, evaluating the effects of drugs, and regenerative medicine. We were interested in disease models using a patient-induced pluripotent stem (iPS) cell-derived cardiomyocytes because of their similarity to a patient’s tissues. However, as these studies have just begun, we would like to review the literature in this and other related fields and discuss the path for future models of molecular biology that can help to diagnose and cure diseases, and its involvement in regenerative medicine. The heterogeneity of iPS cells and/or differentiated cardiomyocytes has been recognized as a problem. An in vitro heart disease model should be evaluated using molecular biological analyses, such as mRNA and micro-RNA expression profiles and proteomic analysis. |
url |
http://dx.doi.org/10.1155/2012/439219 |
work_keys_str_mv |
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1716779856007528448 |