Sphingosine 1-phosphate receptors and sphingosine kinase 1: novel biomarkers for clinical prognosis in breast, prostate, and hematological cancers

Sphingosine 1-phosphate receptors and sphingosine kinase 1: novel biomarkers for clinical prognosis in breast, prostate, and hematological cancers

There is substantial evidence for a role in cancer of the bioactive lipid sphingosine 1-phosphate (S1P), the enzyme sphingosine kinase 1 (that catalyses S1P formation) and S1P-specific G protein coupled receptors. This perspective highlights recent findings demonstrating that sphingosine kinase 1 a...

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Bibliographic Details
Main Authors: Susan ePyne, Joanne eEdwards, Jan eOhotski, Nigel John Pyne
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-12-01
Series:Frontiers in Oncology
Subjects:
Recurrence
estrogen receptor
sphingosine kinase
Triple negative breast cancer
sphingosine 1-phosphate receptors
disease-specific survival
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2012.00168/full

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