The Determination of Protonation Constants of Peptidomimetic Cyclophanes in Binary Methanol-Water Mixtures

The Determination of Protonation Constants of Peptidomimetic Cyclophanes in Binary Methanol-Water Mixtures

The protonation constants of new group of peptidomimetic cyclophanes with valine or phenylalanine moieties incorporated into the macrocyclic skeleton as well as their linear analogues were determined by potentiometric measurements in solutions of methanol-water mixtures at 25°C and constant ionic st...

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Main Authors: Piotr Seliger, Danuta Tomczyk, Grzegorz Andrijewski, Ewa Tomal
Format: Article
Language:English
Published: Hindawi Limited 2016-01-01
Series:Journal of Analytical Methods in Chemistry
Online Access:http://dx.doi.org/10.1155/2016/1721069
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spelling doaj-87d55b93273c47dc8af06c84e5af19352020-11-25T00:54:34ZengHindawi LimitedJournal of Analytical Methods in Chemistry2090-88652090-88732016-01-01201610.1155/2016/17210691721069The Determination of Protonation Constants of Peptidomimetic Cyclophanes in Binary Methanol-Water MixturesPiotr Seliger0Danuta Tomczyk1Grzegorz Andrijewski2Ewa Tomal3Department of Inorganic and Analytical Chemistry, University of Lodz, Tamka 12, 91-403 Lodz, PolandDepartment of Inorganic and Analytical Chemistry, University of Lodz, Tamka 12, 91-403 Lodz, PolandDepartment of Inorganic and Analytical Chemistry, University of Lodz, Tamka 12, 91-403 Lodz, PolandDepartment of Biochemistry and Genetics, Institute of Biology, Jan Kochanowski University in Kielce, Swietokrzyska 15 A, 25-406 Kielce, PolandThe protonation constants of new group of peptidomimetic cyclophanes with valine or phenylalanine moieties incorporated into the macrocyclic skeleton as well as their linear analogues were determined by potentiometric measurements in solutions of methanol-water mixtures at 25°C and constant ionic strength. The influence of cavity size, location of protonation sites, and attached substituents of the macrocyclic ligands on the protonation constants were discussed on the basis of potentiometric measurement as well as H1-NMR results.http://dx.doi.org/10.1155/2016/1721069
collection DOAJ
language English
format Article
sources DOAJ
author Piotr Seliger
Danuta Tomczyk
Grzegorz Andrijewski
Ewa Tomal
spellingShingle Piotr Seliger
Danuta Tomczyk
Grzegorz Andrijewski
Ewa Tomal
The Determination of Protonation Constants of Peptidomimetic Cyclophanes in Binary Methanol-Water Mixtures
Journal of Analytical Methods in Chemistry
author_facet Piotr Seliger
Danuta Tomczyk
Grzegorz Andrijewski
Ewa Tomal
author_sort Piotr Seliger
title The Determination of Protonation Constants of Peptidomimetic Cyclophanes in Binary Methanol-Water Mixtures
title_short The Determination of Protonation Constants of Peptidomimetic Cyclophanes in Binary Methanol-Water Mixtures
title_full The Determination of Protonation Constants of Peptidomimetic Cyclophanes in Binary Methanol-Water Mixtures
title_fullStr The Determination of Protonation Constants of Peptidomimetic Cyclophanes in Binary Methanol-Water Mixtures
title_full_unstemmed The Determination of Protonation Constants of Peptidomimetic Cyclophanes in Binary Methanol-Water Mixtures
title_sort determination of protonation constants of peptidomimetic cyclophanes in binary methanol-water mixtures
publisher Hindawi Limited
series Journal of Analytical Methods in Chemistry
issn 2090-8865
2090-8873
publishDate 2016-01-01
description The protonation constants of new group of peptidomimetic cyclophanes with valine or phenylalanine moieties incorporated into the macrocyclic skeleton as well as their linear analogues were determined by potentiometric measurements in solutions of methanol-water mixtures at 25°C and constant ionic strength. The influence of cavity size, location of protonation sites, and attached substituents of the macrocyclic ligands on the protonation constants were discussed on the basis of potentiometric measurement as well as H1-NMR results.
url http://dx.doi.org/10.1155/2016/1721069
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