Evaluation of hepatoprotective effect of chloroform and methanol extracts of Opuntia monacantha in paracetamol-induced hepatotoxicity in rabbits
The chloroform and methanol extracts of Opuntia monacantha were studied for its hepatoprotective effect against paracetamol induced liver damage in rabbits. Results proved that both extracts at 200, 400 and 600 mg/kg body weight in one week protocol showed significant (p<0.001) hepatoprotective a...
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doaj-87d97a24ae1444138de908a5aed7cd3a2020-11-25T00:01:44ZengBangladesh Pharmacological SocietyBangladesh Journal of Pharmacology1991-007X1991-00882015-03-011011620Evaluation of hepatoprotective effect of chloroform and methanol extracts of Opuntia monacantha in paracetamol-induced hepatotoxicity in rabbitsMohammad SaleemIram IrshadMuhammad Kashif BaigFaiza NaseerThe chloroform and methanol extracts of Opuntia monacantha were studied for its hepatoprotective effect against paracetamol induced liver damage in rabbits. Results proved that both extracts at 200, 400 and 600 mg/kg body weight in one week protocol showed significant (p<0.001) hepatoprotective activity by reducing the magnitude of liver markers including alanine aminotransferase, aspartate aminotransferase, alkaline phasphatase and total bilirubin levels. The results were supported by histopathological studies of liver tissue. Chemical analysis of O. monacantha indicated the presence of alkaloids, tannins, saponins, flavonoids and polysaccharides and its hepato-protective potential may be due to the presence of flavonoids. Its is concluded that 600 mg/kg is the potent dose of both extracts of O. monacantha as hepatoprotective plant.http://www.banglajol.info/bd/index.php/BJP/article/view/20825HepatoprotectiveOpuntia monacanthaParacetamolSilymarin |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mohammad Saleem Iram Irshad Muhammad Kashif Baig Faiza Naseer |
spellingShingle |
Mohammad Saleem Iram Irshad Muhammad Kashif Baig Faiza Naseer Evaluation of hepatoprotective effect of chloroform and methanol extracts of Opuntia monacantha in paracetamol-induced hepatotoxicity in rabbits Bangladesh Journal of Pharmacology Hepatoprotective Opuntia monacantha Paracetamol Silymarin |
author_facet |
Mohammad Saleem Iram Irshad Muhammad Kashif Baig Faiza Naseer |
author_sort |
Mohammad Saleem |
title |
Evaluation of hepatoprotective effect of chloroform and methanol extracts of Opuntia monacantha in paracetamol-induced hepatotoxicity in rabbits |
title_short |
Evaluation of hepatoprotective effect of chloroform and methanol extracts of Opuntia monacantha in paracetamol-induced hepatotoxicity in rabbits |
title_full |
Evaluation of hepatoprotective effect of chloroform and methanol extracts of Opuntia monacantha in paracetamol-induced hepatotoxicity in rabbits |
title_fullStr |
Evaluation of hepatoprotective effect of chloroform and methanol extracts of Opuntia monacantha in paracetamol-induced hepatotoxicity in rabbits |
title_full_unstemmed |
Evaluation of hepatoprotective effect of chloroform and methanol extracts of Opuntia monacantha in paracetamol-induced hepatotoxicity in rabbits |
title_sort |
evaluation of hepatoprotective effect of chloroform and methanol extracts of opuntia monacantha in paracetamol-induced hepatotoxicity in rabbits |
publisher |
Bangladesh Pharmacological Society |
series |
Bangladesh Journal of Pharmacology |
issn |
1991-007X 1991-0088 |
publishDate |
2015-03-01 |
description |
The chloroform and methanol extracts of Opuntia monacantha were studied for its hepatoprotective effect against paracetamol induced liver damage in rabbits. Results proved that both extracts at 200, 400 and 600 mg/kg body weight in one week protocol showed significant (p<0.001) hepatoprotective activity by reducing the magnitude of liver markers including alanine aminotransferase, aspartate aminotransferase, alkaline phasphatase and total bilirubin levels. The results were supported by histopathological studies of liver tissue. Chemical analysis of O. monacantha indicated the presence of alkaloids, tannins, saponins, flavonoids and polysaccharides and its hepato-protective potential may be due to the presence of flavonoids. Its is concluded that 600 mg/kg is the potent dose of both extracts of O. monacantha as hepatoprotective plant. |
topic |
Hepatoprotective Opuntia monacantha Paracetamol Silymarin |
url |
http://www.banglajol.info/bd/index.php/BJP/article/view/20825 |
work_keys_str_mv |
AT mohammadsaleem evaluationofhepatoprotectiveeffectofchloroformandmethanolextractsofopuntiamonacanthainparacetamolinducedhepatotoxicityinrabbits AT iramirshad evaluationofhepatoprotectiveeffectofchloroformandmethanolextractsofopuntiamonacanthainparacetamolinducedhepatotoxicityinrabbits AT muhammadkashifbaig evaluationofhepatoprotectiveeffectofchloroformandmethanolextractsofopuntiamonacanthainparacetamolinducedhepatotoxicityinrabbits AT faizanaseer evaluationofhepatoprotectiveeffectofchloroformandmethanolextractsofopuntiamonacanthainparacetamolinducedhepatotoxicityinrabbits |
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