High Prevalence of Human Papillomavirus in Colorectal Cancer in Hispanics: A Case-Control Study
The role of Human Papillomavirus (HPV) in colorectal carcinogenesis remains elusive. Based on the high incidence of HPV-associated malignancies among Puerto Rican Hispanics, this study aimed to assess the prevalence of HPV infection and viral integration in colorectal tissues in order to evaluate it...
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doaj-87da50aa5a6a42e49ec18ac09c63d1442020-11-24T20:55:11ZengHindawi LimitedGastroenterology Research and Practice1687-61211687-630X2016-01-01201610.1155/2016/78967167896716High Prevalence of Human Papillomavirus in Colorectal Cancer in Hispanics: A Case-Control StudyRaul D. Bernabe-Dones0Maria Gonzalez-Pons1Alejandro Villar-Prados2Mercedes Lacourt-Ventura3Heriberto Rodríguez-Arroyo4Sharon Fonseca-Williams5Francisco E. Velazquez6Yaritza Diaz-Algorri7Sofia M. Lopez-Diaz8Nayra Rodríguez9Yasuhiro Yamamura10Marcia Cruz-Correa11School of Health Professions, University of Puerto Rico Medical Sciences Campus, San Juan, PR 00935, USADivision of Gastrointestinal Oncology, University of Puerto Rico Comprehensive Cancer Center, San Juan, PR 00935, USADivision of Gastrointestinal Oncology, University of Puerto Rico Comprehensive Cancer Center, San Juan, PR 00935, USADivision of Gastrointestinal Oncology, University of Puerto Rico Comprehensive Cancer Center, San Juan, PR 00935, USADivision of Gastrointestinal Oncology, University of Puerto Rico Comprehensive Cancer Center, San Juan, PR 00935, USADivision of Gastrointestinal Oncology, University of Puerto Rico Comprehensive Cancer Center, San Juan, PR 00935, USADivision of Gastrointestinal Oncology, University of Puerto Rico Comprehensive Cancer Center, San Juan, PR 00935, USADivision of Gastrointestinal Oncology, University of Puerto Rico Comprehensive Cancer Center, San Juan, PR 00935, USADivision of Gastrointestinal Oncology, University of Puerto Rico Comprehensive Cancer Center, San Juan, PR 00935, USAAIDS Research Program, Ponce Health Sciences University School of Medicine, Ponce, PR, USAAIDS Research Program, Ponce Health Sciences University School of Medicine, Ponce, PR, USASchool of Health Professions, University of Puerto Rico Medical Sciences Campus, San Juan, PR 00935, USAThe role of Human Papillomavirus (HPV) in colorectal carcinogenesis remains elusive. Based on the high incidence of HPV-associated malignancies among Puerto Rican Hispanics, this study aimed to assess the prevalence of HPV infection and viral integration in colorectal tissues in order to evaluate its putative role in colorectal cancer (CRC). In this case-control study, the prevalence of HPV infection in CRC (cases n = 45) and normal colon mucosa from cancer-free subjects (controls n = 36) was assessed by a nested PCR strategy. HPV-16 genotyping was performed in HPV-positive tissues and the physical status of the HPV-16 genome was determined by E2 detection. HPV was detected in 19 of 45 (42.2%) CRC cases (mean age 61.1 ± 10.7 years, 24 males) and in 1 of 36 (2.8%) controls (mean age 60.9 ± 9.6 years, 24 males) with an OR = 25.58 (95% CI 3.21 to 203.49). HPV-16 was detected in 63.2% of the HPV-positive colorectal tumors; genome integration was observed in all HPV-16 positive cases. This is the first report showing the high prevalence of HPV infections in Caribbean Hispanic colorectal tumors. Despite evidence of HPV integration into the host genome, further mechanistic analysis examining HPV oncoprotein expression and the putative role of these oncoproteins in colorectal carcinogenesis is warranted.http://dx.doi.org/10.1155/2016/7896716 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Raul D. Bernabe-Dones Maria Gonzalez-Pons Alejandro Villar-Prados Mercedes Lacourt-Ventura Heriberto Rodríguez-Arroyo Sharon Fonseca-Williams Francisco E. Velazquez Yaritza Diaz-Algorri Sofia M. Lopez-Diaz Nayra Rodríguez Yasuhiro Yamamura Marcia Cruz-Correa |
spellingShingle |
Raul D. Bernabe-Dones Maria Gonzalez-Pons Alejandro Villar-Prados Mercedes Lacourt-Ventura Heriberto Rodríguez-Arroyo Sharon Fonseca-Williams Francisco E. Velazquez Yaritza Diaz-Algorri Sofia M. Lopez-Diaz Nayra Rodríguez Yasuhiro Yamamura Marcia Cruz-Correa High Prevalence of Human Papillomavirus in Colorectal Cancer in Hispanics: A Case-Control Study Gastroenterology Research and Practice |
author_facet |
Raul D. Bernabe-Dones Maria Gonzalez-Pons Alejandro Villar-Prados Mercedes Lacourt-Ventura Heriberto Rodríguez-Arroyo Sharon Fonseca-Williams Francisco E. Velazquez Yaritza Diaz-Algorri Sofia M. Lopez-Diaz Nayra Rodríguez Yasuhiro Yamamura Marcia Cruz-Correa |
author_sort |
Raul D. Bernabe-Dones |
title |
High Prevalence of Human Papillomavirus in Colorectal Cancer in Hispanics: A Case-Control Study |
title_short |
High Prevalence of Human Papillomavirus in Colorectal Cancer in Hispanics: A Case-Control Study |
title_full |
High Prevalence of Human Papillomavirus in Colorectal Cancer in Hispanics: A Case-Control Study |
title_fullStr |
High Prevalence of Human Papillomavirus in Colorectal Cancer in Hispanics: A Case-Control Study |
title_full_unstemmed |
High Prevalence of Human Papillomavirus in Colorectal Cancer in Hispanics: A Case-Control Study |
title_sort |
high prevalence of human papillomavirus in colorectal cancer in hispanics: a case-control study |
publisher |
Hindawi Limited |
series |
Gastroenterology Research and Practice |
issn |
1687-6121 1687-630X |
publishDate |
2016-01-01 |
description |
The role of Human Papillomavirus (HPV) in colorectal carcinogenesis remains elusive. Based on the high incidence of HPV-associated malignancies among Puerto Rican Hispanics, this study aimed to assess the prevalence of HPV infection and viral integration in colorectal tissues in order to evaluate its putative role in colorectal cancer (CRC). In this case-control study, the prevalence of HPV infection in CRC (cases n = 45) and normal colon mucosa from cancer-free subjects (controls n = 36) was assessed by a nested PCR strategy. HPV-16 genotyping was performed in HPV-positive tissues and the physical status of the HPV-16 genome was determined by E2 detection. HPV was detected in 19 of 45 (42.2%) CRC cases (mean age 61.1 ± 10.7 years, 24 males) and in 1 of 36 (2.8%) controls (mean age 60.9 ± 9.6 years, 24 males) with an OR = 25.58 (95% CI 3.21 to 203.49). HPV-16 was detected in 63.2% of the HPV-positive colorectal tumors; genome integration was observed in all HPV-16 positive cases. This is the first report showing the high prevalence of HPV infections in Caribbean Hispanic colorectal tumors. Despite evidence of HPV integration into the host genome, further mechanistic analysis examining HPV oncoprotein expression and the putative role of these oncoproteins in colorectal carcinogenesis is warranted. |
url |
http://dx.doi.org/10.1155/2016/7896716 |
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