Impact of Cognitive Profile on Impulse Control Disorders Presence and Severity in Parkinson's Disease
Background: Impulse control disorders (ICDs) and related behaviors are frequent in Parkinson's disease (PD). Mild cognitive impairment (PD-MCI) and dementia (PDD), both characterized by heterogeneous cognitive phenotypes, are also commonly reported in PD. However, the frequency and severity of...
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doaj-87e1955829004c919f647f898809e9fe2020-11-25T02:10:28ZengFrontiers Media S.A.Frontiers in Neurology1664-22952019-03-011010.3389/fneur.2019.00266429940Impact of Cognitive Profile on Impulse Control Disorders Presence and Severity in Parkinson's DiseaseAlice Martini0Luca Weis1Eleonora Fiorenzato2Roberta Schifano3Valeria Cianci4Angelo Antonini5Roberta Biundo6School of Psychology, Keele University, Newcastle-under-Lyme, United KingdomIRCCS San Camillo Hospital, Venice, ItalyIRCCS San Camillo Hospital, Venice, ItalyIRCCS San Camillo Hospital, Venice, ItalyIRCCS San Camillo Hospital, Venice, ItalyDepartment of Neuroscience (DNS), University of Padua, Padua, ItalyIRCCS San Camillo Hospital, Venice, ItalyBackground: Impulse control disorders (ICDs) and related behaviors are frequent in Parkinson's disease (PD). Mild cognitive impairment (PD-MCI) and dementia (PDD), both characterized by heterogeneous cognitive phenotypes, are also commonly reported in PD. However, the frequency and severity of ICD within PD cognitive states is unknown.Methods: Three hundred and twenty-six PD patients completed a comprehensive neuropsychological assessment and were classified as PD-MCI, PDD, or without cognitive alterations (PD-NC). The Minnesota impulsive disorders interview was used to ascertain the presence (ICD+) or absence (ICD–) of ICD. The Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease-Rating Scale was used to assess ICD severity. A subsample of 286 patients evaluated with the same cognitive tasks was selected in order to investigate the characteristics of ICD in PD cognitive phenotypes.Results: ICDs were present in 55% of PD-NC, in 50% of PD-MCI, and in 42% of PDD patients. Frequencies of ICD+ with attentive (ICD+: 20% vs. ICD–: 4%; p = 0.031) and executive impairments (ICD+: 44% vs. ICD–: 30%; p = 0.027) were higher in the PD-MCI and PDD subgroups, respectively. As expected, no differences were observed in the PD-NC. PD-MCI with attentive impairments presented higher percentage of ICD+ with deficits in the Trail Making Test B-A but not in the Digit Span Sequencing task. In PDD, executive failures concerned Similarities task (ICD+: 67%; ICD–: 29%; p = 0.035), with no differences between ICD+ and ICD– in the Stroop task.Conclusions: Prevalence and severity of ICDs and related behaviors do not differ in PD with different cognitive states. However, ICD+ are more likely to show deficits, respectively in attentive and in executive domains, specifically in the Trail Making Test B-A task for the attention and working memory domain in PD-MCI and in the Similarities task for the executive function domain in PDD. Prospective studies should evaluate if these tests can be used as screening tool for ICDs in PD.https://www.frontiersin.org/article/10.3389/fneur.2019.00266/fullParkinson's diseasemild cognitive impairmentdementiaimpulse control disordercognitive profilecognition |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Alice Martini Luca Weis Eleonora Fiorenzato Roberta Schifano Valeria Cianci Angelo Antonini Roberta Biundo |
spellingShingle |
Alice Martini Luca Weis Eleonora Fiorenzato Roberta Schifano Valeria Cianci Angelo Antonini Roberta Biundo Impact of Cognitive Profile on Impulse Control Disorders Presence and Severity in Parkinson's Disease Frontiers in Neurology Parkinson's disease mild cognitive impairment dementia impulse control disorder cognitive profile cognition |
author_facet |
Alice Martini Luca Weis Eleonora Fiorenzato Roberta Schifano Valeria Cianci Angelo Antonini Roberta Biundo |
author_sort |
Alice Martini |
title |
Impact of Cognitive Profile on Impulse Control Disorders Presence and Severity in Parkinson's Disease |
title_short |
Impact of Cognitive Profile on Impulse Control Disorders Presence and Severity in Parkinson's Disease |
title_full |
Impact of Cognitive Profile on Impulse Control Disorders Presence and Severity in Parkinson's Disease |
title_fullStr |
Impact of Cognitive Profile on Impulse Control Disorders Presence and Severity in Parkinson's Disease |
title_full_unstemmed |
Impact of Cognitive Profile on Impulse Control Disorders Presence and Severity in Parkinson's Disease |
title_sort |
impact of cognitive profile on impulse control disorders presence and severity in parkinson's disease |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Neurology |
issn |
1664-2295 |
publishDate |
2019-03-01 |
description |
Background: Impulse control disorders (ICDs) and related behaviors are frequent in Parkinson's disease (PD). Mild cognitive impairment (PD-MCI) and dementia (PDD), both characterized by heterogeneous cognitive phenotypes, are also commonly reported in PD. However, the frequency and severity of ICD within PD cognitive states is unknown.Methods: Three hundred and twenty-six PD patients completed a comprehensive neuropsychological assessment and were classified as PD-MCI, PDD, or without cognitive alterations (PD-NC). The Minnesota impulsive disorders interview was used to ascertain the presence (ICD+) or absence (ICD–) of ICD. The Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease-Rating Scale was used to assess ICD severity. A subsample of 286 patients evaluated with the same cognitive tasks was selected in order to investigate the characteristics of ICD in PD cognitive phenotypes.Results: ICDs were present in 55% of PD-NC, in 50% of PD-MCI, and in 42% of PDD patients. Frequencies of ICD+ with attentive (ICD+: 20% vs. ICD–: 4%; p = 0.031) and executive impairments (ICD+: 44% vs. ICD–: 30%; p = 0.027) were higher in the PD-MCI and PDD subgroups, respectively. As expected, no differences were observed in the PD-NC. PD-MCI with attentive impairments presented higher percentage of ICD+ with deficits in the Trail Making Test B-A but not in the Digit Span Sequencing task. In PDD, executive failures concerned Similarities task (ICD+: 67%; ICD–: 29%; p = 0.035), with no differences between ICD+ and ICD– in the Stroop task.Conclusions: Prevalence and severity of ICDs and related behaviors do not differ in PD with different cognitive states. However, ICD+ are more likely to show deficits, respectively in attentive and in executive domains, specifically in the Trail Making Test B-A task for the attention and working memory domain in PD-MCI and in the Similarities task for the executive function domain in PDD. Prospective studies should evaluate if these tests can be used as screening tool for ICDs in PD. |
topic |
Parkinson's disease mild cognitive impairment dementia impulse control disorder cognitive profile cognition |
url |
https://www.frontiersin.org/article/10.3389/fneur.2019.00266/full |
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