The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation

The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation

The NLRP3 inflammasome is a critical component of the innate immune system that mediates caspase-1 activation and the secretion of proinflammatory cytokines IL-1β/IL-18 in response to microbial infection and cellular damage. However, the aberrant activation of the NLRP3 inflammasome has bee...

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Bibliographic Details
Main Authors: Nathan Kelley, Devon Jeltema, Yanhui Duan, Yuan He
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:International Journal of Molecular Sciences
Subjects:
NLRP3 inflammasome
Priming
Ionic flux
ROS
Mitochondrial dysfunction
Lysosomal damage
Post-translational modification
NLRP3 regulators
Online Access:https://www.mdpi.com/1422-0067/20/13/3328

Internet

https://www.mdpi.com/1422-0067/20/13/3328

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