Excision of a Large Gastrointestinal Stromal Tumour Following 16 Months of Neoadjuvant Therapy with Imatinib (Case Report)

Abstract Introduction Although the standard treatment for stromal tumours is surgery, in locally advanced forms, it is often necessary to achieve tumour downstaging to improve surgical outcomes. Neoadjuvant treatment in gastrointestinal stromal tumours (GISTs) with tyrosine kinase inhibitors, includ...

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Main Authors: Fousséni Alassani, Boyodi Tchangai, Aklesso Bagny, Ablavi A. Adani-Ife, Kossigan A. Amavi, Tchin Darre, Komla Attipou
Format: Article
Language:English
Published: Adis, Springer Healthcare 2019-11-01
Series:Oncology and Therapy
Subjects:
Online Access:http://link.springer.com/article/10.1007/s40487-019-00101-4
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spelling doaj-87f3d79d9e6045e0b6abb67f1a5282fa2020-11-25T03:58:15ZengAdis, Springer HealthcareOncology and Therapy2366-10702366-10892019-11-017215916410.1007/s40487-019-00101-4Excision of a Large Gastrointestinal Stromal Tumour Following 16 Months of Neoadjuvant Therapy with Imatinib (Case Report)Fousséni Alassani0Boyodi Tchangai1Aklesso Bagny2Ablavi A. Adani-Ife3Kossigan A. Amavi4Tchin Darre5Komla Attipou6Department of Visceral Surgery, University Teaching Hospital of LoméDepartment of Visceral Surgery, University Teaching Hospital of LoméDepartment of Hepato-Gastro-Enterology, University Teaching Hospital of LoméDepartment of Medical Oncology, University Teaching Hospital of LoméDepartment of General Surgery, University Teaching Hospital of LoméDepartment of Pathology, University Teaching Hospital of LoméDepartment of Visceral Surgery, University Teaching Hospital of LoméAbstract Introduction Although the standard treatment for stromal tumours is surgery, in locally advanced forms, it is often necessary to achieve tumour downstaging to improve surgical outcomes. Neoadjuvant treatment in gastrointestinal stromal tumours (GISTs) with tyrosine kinase inhibitors, including imatinib, has been shown to be effective in several studies, but the duration of this treatment is still a subject of debate. Case report We report a case of a large GIST of the stomach in a 51-year-old patient with atypical presentation that was initially unresectable. Neoadjuvant treatment with imatinib for 16 months resulted in a good response, allowing secondary surgical excision. Conclusion Imatinib in neoadjuvant therapy should be continued as long as there is a good response and tolerance to the medication to obtain tumour downsizing compatible with carcinologic excision.http://link.springer.com/article/10.1007/s40487-019-00101-4GISTImatinibNeoadjuvant therapySurgery
collection DOAJ
language English
format Article
sources DOAJ
author Fousséni Alassani
Boyodi Tchangai
Aklesso Bagny
Ablavi A. Adani-Ife
Kossigan A. Amavi
Tchin Darre
Komla Attipou
spellingShingle Fousséni Alassani
Boyodi Tchangai
Aklesso Bagny
Ablavi A. Adani-Ife
Kossigan A. Amavi
Tchin Darre
Komla Attipou
Excision of a Large Gastrointestinal Stromal Tumour Following 16 Months of Neoadjuvant Therapy with Imatinib (Case Report)
Oncology and Therapy
GIST
Imatinib
Neoadjuvant therapy
Surgery
author_facet Fousséni Alassani
Boyodi Tchangai
Aklesso Bagny
Ablavi A. Adani-Ife
Kossigan A. Amavi
Tchin Darre
Komla Attipou
author_sort Fousséni Alassani
title Excision of a Large Gastrointestinal Stromal Tumour Following 16 Months of Neoadjuvant Therapy with Imatinib (Case Report)
title_short Excision of a Large Gastrointestinal Stromal Tumour Following 16 Months of Neoadjuvant Therapy with Imatinib (Case Report)
title_full Excision of a Large Gastrointestinal Stromal Tumour Following 16 Months of Neoadjuvant Therapy with Imatinib (Case Report)
title_fullStr Excision of a Large Gastrointestinal Stromal Tumour Following 16 Months of Neoadjuvant Therapy with Imatinib (Case Report)
title_full_unstemmed Excision of a Large Gastrointestinal Stromal Tumour Following 16 Months of Neoadjuvant Therapy with Imatinib (Case Report)
title_sort excision of a large gastrointestinal stromal tumour following 16 months of neoadjuvant therapy with imatinib (case report)
publisher Adis, Springer Healthcare
series Oncology and Therapy
issn 2366-1070
2366-1089
publishDate 2019-11-01
description Abstract Introduction Although the standard treatment for stromal tumours is surgery, in locally advanced forms, it is often necessary to achieve tumour downstaging to improve surgical outcomes. Neoadjuvant treatment in gastrointestinal stromal tumours (GISTs) with tyrosine kinase inhibitors, including imatinib, has been shown to be effective in several studies, but the duration of this treatment is still a subject of debate. Case report We report a case of a large GIST of the stomach in a 51-year-old patient with atypical presentation that was initially unresectable. Neoadjuvant treatment with imatinib for 16 months resulted in a good response, allowing secondary surgical excision. Conclusion Imatinib in neoadjuvant therapy should be continued as long as there is a good response and tolerance to the medication to obtain tumour downsizing compatible with carcinologic excision.
topic GIST
Imatinib
Neoadjuvant therapy
Surgery
url http://link.springer.com/article/10.1007/s40487-019-00101-4
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