Excision of a Large Gastrointestinal Stromal Tumour Following 16 Months of Neoadjuvant Therapy with Imatinib (Case Report)
Abstract Introduction Although the standard treatment for stromal tumours is surgery, in locally advanced forms, it is often necessary to achieve tumour downstaging to improve surgical outcomes. Neoadjuvant treatment in gastrointestinal stromal tumours (GISTs) with tyrosine kinase inhibitors, includ...
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doaj-87f3d79d9e6045e0b6abb67f1a5282fa2020-11-25T03:58:15ZengAdis, Springer HealthcareOncology and Therapy2366-10702366-10892019-11-017215916410.1007/s40487-019-00101-4Excision of a Large Gastrointestinal Stromal Tumour Following 16 Months of Neoadjuvant Therapy with Imatinib (Case Report)Fousséni Alassani0Boyodi Tchangai1Aklesso Bagny2Ablavi A. Adani-Ife3Kossigan A. Amavi4Tchin Darre5Komla Attipou6Department of Visceral Surgery, University Teaching Hospital of LoméDepartment of Visceral Surgery, University Teaching Hospital of LoméDepartment of Hepato-Gastro-Enterology, University Teaching Hospital of LoméDepartment of Medical Oncology, University Teaching Hospital of LoméDepartment of General Surgery, University Teaching Hospital of LoméDepartment of Pathology, University Teaching Hospital of LoméDepartment of Visceral Surgery, University Teaching Hospital of LoméAbstract Introduction Although the standard treatment for stromal tumours is surgery, in locally advanced forms, it is often necessary to achieve tumour downstaging to improve surgical outcomes. Neoadjuvant treatment in gastrointestinal stromal tumours (GISTs) with tyrosine kinase inhibitors, including imatinib, has been shown to be effective in several studies, but the duration of this treatment is still a subject of debate. Case report We report a case of a large GIST of the stomach in a 51-year-old patient with atypical presentation that was initially unresectable. Neoadjuvant treatment with imatinib for 16 months resulted in a good response, allowing secondary surgical excision. Conclusion Imatinib in neoadjuvant therapy should be continued as long as there is a good response and tolerance to the medication to obtain tumour downsizing compatible with carcinologic excision.http://link.springer.com/article/10.1007/s40487-019-00101-4GISTImatinibNeoadjuvant therapySurgery |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Fousséni Alassani Boyodi Tchangai Aklesso Bagny Ablavi A. Adani-Ife Kossigan A. Amavi Tchin Darre Komla Attipou |
spellingShingle |
Fousséni Alassani Boyodi Tchangai Aklesso Bagny Ablavi A. Adani-Ife Kossigan A. Amavi Tchin Darre Komla Attipou Excision of a Large Gastrointestinal Stromal Tumour Following 16 Months of Neoadjuvant Therapy with Imatinib (Case Report) Oncology and Therapy GIST Imatinib Neoadjuvant therapy Surgery |
author_facet |
Fousséni Alassani Boyodi Tchangai Aklesso Bagny Ablavi A. Adani-Ife Kossigan A. Amavi Tchin Darre Komla Attipou |
author_sort |
Fousséni Alassani |
title |
Excision of a Large Gastrointestinal Stromal Tumour Following 16 Months of Neoadjuvant Therapy with Imatinib (Case Report) |
title_short |
Excision of a Large Gastrointestinal Stromal Tumour Following 16 Months of Neoadjuvant Therapy with Imatinib (Case Report) |
title_full |
Excision of a Large Gastrointestinal Stromal Tumour Following 16 Months of Neoadjuvant Therapy with Imatinib (Case Report) |
title_fullStr |
Excision of a Large Gastrointestinal Stromal Tumour Following 16 Months of Neoadjuvant Therapy with Imatinib (Case Report) |
title_full_unstemmed |
Excision of a Large Gastrointestinal Stromal Tumour Following 16 Months of Neoadjuvant Therapy with Imatinib (Case Report) |
title_sort |
excision of a large gastrointestinal stromal tumour following 16 months of neoadjuvant therapy with imatinib (case report) |
publisher |
Adis, Springer Healthcare |
series |
Oncology and Therapy |
issn |
2366-1070 2366-1089 |
publishDate |
2019-11-01 |
description |
Abstract Introduction Although the standard treatment for stromal tumours is surgery, in locally advanced forms, it is often necessary to achieve tumour downstaging to improve surgical outcomes. Neoadjuvant treatment in gastrointestinal stromal tumours (GISTs) with tyrosine kinase inhibitors, including imatinib, has been shown to be effective in several studies, but the duration of this treatment is still a subject of debate. Case report We report a case of a large GIST of the stomach in a 51-year-old patient with atypical presentation that was initially unresectable. Neoadjuvant treatment with imatinib for 16 months resulted in a good response, allowing secondary surgical excision. Conclusion Imatinib in neoadjuvant therapy should be continued as long as there is a good response and tolerance to the medication to obtain tumour downsizing compatible with carcinologic excision. |
topic |
GIST Imatinib Neoadjuvant therapy Surgery |
url |
http://link.springer.com/article/10.1007/s40487-019-00101-4 |
work_keys_str_mv |
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