Synthesis and antibacterial activity of some heterocyclic derivatives of sulfanilamide

Synthesis and antibacterial activity of some heterocyclic derivatives of sulfanilamide

Considering the promising antimicrobial potential of carbonic anhydrase inhibitors and heterocyclic compounds some heterocyclic derivatives of sulfanilamide (2a-e) were synthesized. The diazotisation of sulfanilamide followed by substitution with ethylacetoacetate and further condensation yielded co...

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Bibliographic Details
Main Authors: B.B. Subudhi, G. Ghosh
Format: Article
Language:English
Published: Chemical Society of Ethiopia 2012-12-01
Series:Bulletin of the Chemical Society of Ethiopia
Subjects:
Carbonic anhydrase
Sulfanilamide
Heterocyclic compounds
Antimicrobial activity
Online Access:http://www.ajol.info/index.php/bcse/article/view/80286
Description
Summary:Considering the promising antimicrobial potential of carbonic anhydrase inhibitors and heterocyclic compounds some heterocyclic derivatives of sulfanilamide (2a-e) were synthesized. The diazotisation of sulfanilamide followed by substitution with ethylacetoacetate and further condensation yielded compounds 2a-c. Schiff base of sulfanilamide with salicylaldehyde on reaction with thioglycollic acid and chloroacetyl chloride resulted in compound 2d-e. The susceptibility of <i>Staphylococcus aureus</i>, <i>Enterococcus faecalis</i>, <i>Escherichia coli</i> and <i>Pseudomonas aeruginosa</i> to the title compounds (300 &mu;g/disc) was investigated and compared to that of nitrofurantoin (300 &mu;g/disc) and ciprofloxacin (25 &mu;g/disc). The title compounds showed good antimicrobial activity.DOI: http://dx.doi.org/10.4314/bcse.v26i3.15
ISSN:1011-3924
1726-801X

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