Synthesis and antibacterial activity of some heterocyclic derivatives of sulfanilamide

• Main Authors: B.B. Subudhi, G. Ghosh
• Format: Article
• Language: English
• Published: Chemical Society of Ethiopia 2012-12-01
• Series: Bulletin of the Chemical Society of Ethiopia
• Subjects: Carbonic anhydrase; Sulfanilamide; Heterocyclic compounds; Antimicrobial activity
• Online Access: http://www.ajol.info/index.php/bcse/article/view/80286

Considering the promising antimicrobial potential of carbonic anhydrase inhibitors and heterocyclic compounds some heterocyclic derivatives of sulfanilamide (2a-e) were synthesized. The diazotisation of sulfanilamide followed by substitution with ethylacetoacetate and further condensation yielded compounds 2a-c. Schiff base of sulfanilamide with salicylaldehyde on reaction with thioglycollic acid and chloroacetyl chloride resulted in compound 2d-e. The susceptibility of <i>Staphylococcus aureus</i>, <i>Enterococcus faecalis</i>, <i>Escherichia coli</i> and <i>Pseudomonas aeruginosa</i> to the title compounds (300 &mu;g/disc) was investigated and compared to that of nitrofurantoin (300 &mu;g/disc) and ciprofloxacin (25 &mu;g/disc). The title compounds showed good antimicrobial activity.DOI: http://dx.doi.org/10.4314/bcse.v26i3.15