Crucial Role of Microbiota in Experimental Psoriasis Revealed by a Gnotobiotic Mouse Model

Crucial Role of Microbiota in Experimental Psoriasis Revealed by a Gnotobiotic Mouse Model

Psoriatic patients have altered microbiota, both in the intestine and on the skin. It is not clear, however, whether this is a cause or consequence of the disease. In this study, using an experimental mouse model of psoriasis induced by imiquimod (IMQ), we show that oral treatment with a broad spect...

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Bibliographic Details
Main Authors: Zuzana Stehlikova, Klara Kostovcikova, Miloslav Kverka, Pavel Rossmann, Jiri Dvorak, Iva Novosadova, Martin Kostovcik, Stepan Coufal, Dagmar Srutkova, Petra Prochazkova, Tomas Hudcovic, Hana Kozakova, Renata Stepankova, Filip Rob, Katerina Juzlova, Jana Hercogova, Helena Tlaskalova-Hogenova, Zuzana Jiraskova Zakostelska
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Microbiology
Subjects:
psoriasis
antibiotics
microbiota
germ-free
animal model
imiquimod
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.00236/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2019.00236/full

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