The C5a/C5a receptor 1 axis controls tissue neovascularization through CXCL4 release from platelets

The C5a/C5a receptor 1 axis controls tissue neovascularization through CXCL4 release from platelets

As more intersection points between platelets and the immune system are found, the role of platelets for vessel growth in the adult organism remains unclear. The authors demonstrate that platelets negatively modulate revascularization through CXCL4 secretion induced by activation C5aR1 on their surf...

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Main Authors: Henry Nording, Lasse Baron, David Haberthür, Frederic Emschermann, Matthias Mezger, Manuela Sauter, Reinhard Sauter, Johannes Patzelt, Kai Knoepp, Anne Nording, Moritz Meusel, Roza Meyer-Saraei, Ruslan Hlushchuk, Daniel Sedding, Oliver Borst, Ingo Eitel, Christian M. Karsten, Robert Feil, Bernd Pichler, Jeanette Erdmann, Admar Verschoor, Emmanouil Chavakis, Triantafyllos Chavakis, Philipp von Hundelshausen, Jörg Köhl, Meinrad Gawaz, Harald F. Langer
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-23499-w
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spelling doaj-87faa2a159a0413296eadbb6d07bb8c02021-06-13T11:15:00ZengNature Publishing GroupNature Communications2041-17232021-06-0112112210.1038/s41467-021-23499-wThe C5a/C5a receptor 1 axis controls tissue neovascularization through CXCL4 release from plateletsHenry Nording0Lasse Baron1David Haberthür2Frederic Emschermann3Matthias Mezger4Manuela Sauter5Reinhard Sauter6Johannes Patzelt7Kai Knoepp8Anne Nording9Moritz Meusel10Roza Meyer-Saraei11Ruslan Hlushchuk12Daniel Sedding13Oliver Borst14Ingo Eitel15Christian M. Karsten16Robert Feil17Bernd Pichler18Jeanette Erdmann19Admar Verschoor20Emmanouil Chavakis21Triantafyllos Chavakis22Philipp von Hundelshausen23Jörg Köhl24Meinrad Gawaz25Harald F. Langer26Cardioimmunology Group, Medical Clinic II, University Heart Center LübeckCardioimmunology Group, Medical Clinic II, University Heart Center LübeckInstitute of Anatomy, University of BernUniversity Hospital, Department of Cardiovascular Medicine, Eberhard Karls UniversityCardioimmunology Group, Medical Clinic II, University Heart Center LübeckCardioimmunology Group, Medical Clinic II, University Heart Center LübeckCardioimmunology Group, Medical Clinic II, University Heart Center LübeckUniversity Hospital, Medical Clinic II, University Heart Center LübeckDepartment of Internal Medicine III, Cardiology, Angiology and Intensive Care Medicine, Martin-Luther-University Halle (Saale)Institute of Medical Genetics and Applied Genomics, Eberhard Karls UniversityUniversity Hospital, Medical Clinic II, University Heart Center LübeckDZHK (German Centre for Cardiovascular Research), partner site Hamburg/Lübeck/KielInstitute of Anatomy, University of BernDepartment of Internal Medicine III, Cardiology, Angiology and Intensive Care Medicine, Martin-Luther-University Halle (Saale)University Hospital, Department of Cardiovascular Medicine, Eberhard Karls UniversityDZHK (German Centre for Cardiovascular Research), partner site Hamburg/Lübeck/KielInstitute for Systemic Inflammation Research, University of LübeckInterfaculty Institute of Biochemistry, University of TübingenInstitute for Preclinical Imaging, Eberhard Karls UniversityDZHK (German Centre for Cardiovascular Research), partner site Hamburg/Lübeck/KielInstitute for Systemic Inflammation Research, University of LübeckDepartment for Internal Medicine III/Cardiology, University Hospital of the Johann-Wolfgang Goethe UniversityDepartment of Clinical Pathobiochemistry, Institute of Clinical Chemistry and Laboratory Medicine, Medical Faculty, Technische Universität DresdenInstitute for Cardiovascular Prevention, Ludwig Maximilians University MunichInstitute for Systemic Inflammation Research, University of LübeckUniversity Hospital, Department of Cardiovascular Medicine, Eberhard Karls UniversityCardioimmunology Group, Medical Clinic II, University Heart Center LübeckAs more intersection points between platelets and the immune system are found, the role of platelets for vessel growth in the adult organism remains unclear. The authors demonstrate that platelets negatively modulate revascularization through CXCL4 secretion induced by activation C5aR1 on their surface.https://doi.org/10.1038/s41467-021-23499-w
collection DOAJ
language English
format Article
sources DOAJ
author Henry Nording
Lasse Baron
David Haberthür
Frederic Emschermann
Matthias Mezger
Manuela Sauter
Reinhard Sauter
Johannes Patzelt
Kai Knoepp
Anne Nording
Moritz Meusel
Roza Meyer-Saraei
Ruslan Hlushchuk
Daniel Sedding
Oliver Borst
Ingo Eitel
Christian M. Karsten
Robert Feil
Bernd Pichler
Jeanette Erdmann
Admar Verschoor
Emmanouil Chavakis
Triantafyllos Chavakis
Philipp von Hundelshausen
Jörg Köhl
Meinrad Gawaz
Harald F. Langer
spellingShingle Henry Nording
Lasse Baron
David Haberthür
Frederic Emschermann
Matthias Mezger
Manuela Sauter
Reinhard Sauter
Johannes Patzelt
Kai Knoepp
Anne Nording
Moritz Meusel
Roza Meyer-Saraei
Ruslan Hlushchuk
Daniel Sedding
Oliver Borst
Ingo Eitel
Christian M. Karsten
Robert Feil
Bernd Pichler
Jeanette Erdmann
Admar Verschoor
Emmanouil Chavakis
Triantafyllos Chavakis
Philipp von Hundelshausen
Jörg Köhl
Meinrad Gawaz
Harald F. Langer
The C5a/C5a receptor 1 axis controls tissue neovascularization through CXCL4 release from platelets
Nature Communications
author_facet Henry Nording
Lasse Baron
David Haberthür
Frederic Emschermann
Matthias Mezger
Manuela Sauter
Reinhard Sauter
Johannes Patzelt
Kai Knoepp
Anne Nording
Moritz Meusel
Roza Meyer-Saraei
Ruslan Hlushchuk
Daniel Sedding
Oliver Borst
Ingo Eitel
Christian M. Karsten
Robert Feil
Bernd Pichler
Jeanette Erdmann
Admar Verschoor
Emmanouil Chavakis
Triantafyllos Chavakis
Philipp von Hundelshausen
Jörg Köhl
Meinrad Gawaz
Harald F. Langer
author_sort Henry Nording
title The C5a/C5a receptor 1 axis controls tissue neovascularization through CXCL4 release from platelets
title_short The C5a/C5a receptor 1 axis controls tissue neovascularization through CXCL4 release from platelets
title_full The C5a/C5a receptor 1 axis controls tissue neovascularization through CXCL4 release from platelets
title_fullStr The C5a/C5a receptor 1 axis controls tissue neovascularization through CXCL4 release from platelets
title_full_unstemmed The C5a/C5a receptor 1 axis controls tissue neovascularization through CXCL4 release from platelets
title_sort c5a/c5a receptor 1 axis controls tissue neovascularization through cxcl4 release from platelets
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-06-01
description As more intersection points between platelets and the immune system are found, the role of platelets for vessel growth in the adult organism remains unclear. The authors demonstrate that platelets negatively modulate revascularization through CXCL4 secretion induced by activation C5aR1 on their surface.
url https://doi.org/10.1038/s41467-021-23499-w
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