Ecology and molecular targets of hypermutation in the global microbiome
Here, the authors report a large-scale comparative analysis of <30,000 Diversity-Generating Retroelements (DGRs) across ~9000 metagenomes (representing diverse taxa and biomes), to identify patterns in terms of prevalence and activity. Combined with examination of longitudinal data on <100 met...
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Nature Publishing Group
2021-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-23402-7 |
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doaj-87fc7301154f4cd7b3582880b432f7e92021-05-30T11:14:33ZengNature Publishing GroupNature Communications2041-17232021-05-0112111210.1038/s41467-021-23402-7Ecology and molecular targets of hypermutation in the global microbiomeSimon Roux0Blair G. Paul1Sarah C. Bagby2Stephen Nayfach3Michelle A. Allen4Graeme Attwood5Ricardo Cavicchioli6Ludmila Chistoserdova7Robert J. Gruninger8Steven J. Hallam9Maria E. Hernandez10Matthias Hess11Wen-Tso Liu12Tim A. McAllister13Michelle A. O’Malley14Xuefeng Peng15Virginia I. Rich16Scott R. Saleska17Emiley A. Eloe-Fadrosh18DOE Joint Genome Institute, Lawrence Berkeley National LaboratoryMarine Biological LaboratoryDepartment of Biology, Case Western Reserve UniversityDOE Joint Genome Institute, Lawrence Berkeley National LaboratoryThe University of New South WalesAgResearch Limited, Grasslands Research CentreThe University of New South WalesUniversity of WashingtonLethbridge Research and Development Centre, Agriculture and Agri-Food CanadaDepartment of Microbiology and Immunology, University of British ColumbiaInstituto de Ecología A.C. Red de Manejo Biotechnológico de Recursos. XalapaUniversity of California DavisUniversity of Illinois at Urbana-ChampaignLethbridge Research and Development Centre, Agriculture and Agri-Food CanadaDepartment of Chemical Engineering, University of California Santa BarbaraMarine Science Institute, University of California Santa BarbaraOhio State UniversityUniversity of ArizonaDOE Joint Genome Institute, Lawrence Berkeley National LaboratoryHere, the authors report a large-scale comparative analysis of <30,000 Diversity-Generating Retroelements (DGRs) across ~9000 metagenomes (representing diverse taxa and biomes), to identify patterns in terms of prevalence and activity. Combined with examination of longitudinal data on <100 metagenomes part of time series, they demonstrate that DGRs are broadly and consistently active, implying an important role in microbiota ecology and evolution.https://doi.org/10.1038/s41467-021-23402-7 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Simon Roux Blair G. Paul Sarah C. Bagby Stephen Nayfach Michelle A. Allen Graeme Attwood Ricardo Cavicchioli Ludmila Chistoserdova Robert J. Gruninger Steven J. Hallam Maria E. Hernandez Matthias Hess Wen-Tso Liu Tim A. McAllister Michelle A. O’Malley Xuefeng Peng Virginia I. Rich Scott R. Saleska Emiley A. Eloe-Fadrosh |
| spellingShingle |
Simon Roux Blair G. Paul Sarah C. Bagby Stephen Nayfach Michelle A. Allen Graeme Attwood Ricardo Cavicchioli Ludmila Chistoserdova Robert J. Gruninger Steven J. Hallam Maria E. Hernandez Matthias Hess Wen-Tso Liu Tim A. McAllister Michelle A. O’Malley Xuefeng Peng Virginia I. Rich Scott R. Saleska Emiley A. Eloe-Fadrosh Ecology and molecular targets of hypermutation in the global microbiome Nature Communications |
| author_facet |
Simon Roux Blair G. Paul Sarah C. Bagby Stephen Nayfach Michelle A. Allen Graeme Attwood Ricardo Cavicchioli Ludmila Chistoserdova Robert J. Gruninger Steven J. Hallam Maria E. Hernandez Matthias Hess Wen-Tso Liu Tim A. McAllister Michelle A. O’Malley Xuefeng Peng Virginia I. Rich Scott R. Saleska Emiley A. Eloe-Fadrosh |
| author_sort |
Simon Roux |
| title |
Ecology and molecular targets of hypermutation in the global microbiome |
| title_short |
Ecology and molecular targets of hypermutation in the global microbiome |
| title_full |
Ecology and molecular targets of hypermutation in the global microbiome |
| title_fullStr |
Ecology and molecular targets of hypermutation in the global microbiome |
| title_full_unstemmed |
Ecology and molecular targets of hypermutation in the global microbiome |
| title_sort |
ecology and molecular targets of hypermutation in the global microbiome |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2021-05-01 |
| description |
Here, the authors report a large-scale comparative analysis of <30,000 Diversity-Generating Retroelements (DGRs) across ~9000 metagenomes (representing diverse taxa and biomes), to identify patterns in terms of prevalence and activity. Combined with examination of longitudinal data on <100 metagenomes part of time series, they demonstrate that DGRs are broadly and consistently active, implying an important role in microbiota ecology and evolution. |
| url |
https://doi.org/10.1038/s41467-021-23402-7 |
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