Adaptation and selection shape clonal evolution of tumors during residual disease and recurrence

The cellular composition of recurrent tumors can provide insight into resistance to therapy and inform on second line therapies. Here, using a genetically modified mouse, the authors perform barcoding experiments of the primary tumors to allow them to study the clonal dynamics of tumor recurrence.

Bibliographic Details
Main Authors:	Andrea Walens, Jiaxing Lin, Jeffrey S. Damrauer, Brock McKinney, Ryan Lupo, Rachel Newcomb, Douglas B. Fox, Nathaniel W. Mabe, Jeremy Gresham, Zhecheng Sheng, Alexander B. Sibley, Tristan De Buysscher, Hemant Kelkar, Piotr A. Mieczkowski, Kouros Owzar, James V. Alvarez
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-10-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-18730-z

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spelling	doaj-88169f662d1448619437707b70a984942021-10-10T11:46:35ZengNature Publishing GroupNature Communications2041-17232020-10-0111111510.1038/s41467-020-18730-zAdaptation and selection shape clonal evolution of tumors during residual disease and recurrenceAndrea Walens0Jiaxing Lin1Jeffrey S. Damrauer2Brock McKinney3Ryan Lupo4Rachel Newcomb5Douglas B. Fox6Nathaniel W. Mabe7Jeremy Gresham8Zhecheng Sheng9Alexander B. Sibley10Tristan De Buysscher11Hemant Kelkar12Piotr A. Mieczkowski13Kouros Owzar14James V. Alvarez15Department of Pharmacology and Cancer Biology, Duke UniversityDepartment of Biostatistics and Bioinformatics, Duke UniversityDepartment of Pharmacology and Cancer Biology, Duke UniversityDepartment of Pharmacology and Cancer Biology, Duke UniversityDepartment of Pharmacology and Cancer Biology, Duke UniversityDepartment of Pharmacology and Cancer Biology, Duke UniversityDepartment of Pharmacology and Cancer Biology, Duke UniversityDepartment of Pharmacology and Cancer Biology, Duke UniversityDuke Cancer Institute, Duke UniversityDuke Cancer Institute, Duke UniversityDuke Cancer Institute, Duke UniversityLineberger Comprehensive Cancer Center, University of North CarolinaDepartment of Genetics, University of North CarolinaLineberger Comprehensive Cancer Center, University of North CarolinaDepartment of Biostatistics and Bioinformatics, Duke UniversityDepartment of Pharmacology and Cancer Biology, Duke UniversityThe cellular composition of recurrent tumors can provide insight into resistance to therapy and inform on second line therapies. Here, using a genetically modified mouse, the authors perform barcoding experiments of the primary tumors to allow them to study the clonal dynamics of tumor recurrence.https://doi.org/10.1038/s41467-020-18730-z
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Andrea Walens Jiaxing Lin Jeffrey S. Damrauer Brock McKinney Ryan Lupo Rachel Newcomb Douglas B. Fox Nathaniel W. Mabe Jeremy Gresham Zhecheng Sheng Alexander B. Sibley Tristan De Buysscher Hemant Kelkar Piotr A. Mieczkowski Kouros Owzar James V. Alvarez
spellingShingle	Andrea Walens Jiaxing Lin Jeffrey S. Damrauer Brock McKinney Ryan Lupo Rachel Newcomb Douglas B. Fox Nathaniel W. Mabe Jeremy Gresham Zhecheng Sheng Alexander B. Sibley Tristan De Buysscher Hemant Kelkar Piotr A. Mieczkowski Kouros Owzar James V. Alvarez Adaptation and selection shape clonal evolution of tumors during residual disease and recurrence Nature Communications
author_facet	Andrea Walens Jiaxing Lin Jeffrey S. Damrauer Brock McKinney Ryan Lupo Rachel Newcomb Douglas B. Fox Nathaniel W. Mabe Jeremy Gresham Zhecheng Sheng Alexander B. Sibley Tristan De Buysscher Hemant Kelkar Piotr A. Mieczkowski Kouros Owzar James V. Alvarez
author_sort	Andrea Walens
title	Adaptation and selection shape clonal evolution of tumors during residual disease and recurrence
title_short	Adaptation and selection shape clonal evolution of tumors during residual disease and recurrence
title_full	Adaptation and selection shape clonal evolution of tumors during residual disease and recurrence
title_fullStr	Adaptation and selection shape clonal evolution of tumors during residual disease and recurrence
title_full_unstemmed	Adaptation and selection shape clonal evolution of tumors during residual disease and recurrence
title_sort	adaptation and selection shape clonal evolution of tumors during residual disease and recurrence
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-10-01
description	The cellular composition of recurrent tumors can provide insight into resistance to therapy and inform on second line therapies. Here, using a genetically modified mouse, the authors perform barcoding experiments of the primary tumors to allow them to study the clonal dynamics of tumor recurrence.
url	https://doi.org/10.1038/s41467-020-18730-z
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Adaptation and selection shape clonal evolution of tumors during residual disease and recurrence

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