Truncation and constitutive activation of the androgen receptor by diverse genomic rearrangements in prostate cancer
Castration-resistant prostate cancer frequently presents with persistent androgen receptor signalling. Here, the authors find that the androgen receptor is subject to genetic rearrangements, resulting in variants with ligand-independent activity.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2016-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms13668 |
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doaj-881742f5c87d4d33a058d2ab18e6588c2021-05-11T10:40:33ZengNature Publishing GroupNature Communications2041-17232016-11-017111210.1038/ncomms13668Truncation and constitutive activation of the androgen receptor by diverse genomic rearrangements in prostate cancerChristine Henzler0Yingming Li1Rendong Yang2Terri McBride3Yeung Ho4Cynthia Sprenger5Gang Liu6Ilsa Coleman7Bryce Lakely8Rui Li9Shihong Ma10Sean R. Landman11Vipin Kumar12Tae Hyun Hwang13Ganesh V. Raj14Celestia S. Higano15Colm Morrissey16Peter S. Nelson17Stephen R. Plymate18Scott M. Dehm19Minnesota Supercomputing Institute, University of MinnesotaMasonic Cancer Center, University of MinnesotaMinnesota Supercomputing Institute, University of MinnesotaMasonic Cancer Center, University of MinnesotaMasonic Cancer Center, University of MinnesotaDivision of Gerontology and Geriatric Medicine, University of WashingtonDivision of Gerontology and Geriatric Medicine, University of WashingtonFred Hutchinson Cancer Research CenterDepartment of Urology, University of WashingtonDepartment of Urology, University of Texas Southwestern Medical CenterDepartment of Urology, University of Texas Southwestern Medical CenterDepartment of Computer Science and Engineering, University of MinnesotaDepartment of Computer Science and Engineering, University of MinnesotaQuantitative Biomedical Research Center, University of Texas Southwestern Medical CenterDepartment of Urology, University of Texas Southwestern Medical CenterFred Hutchinson Cancer Research CenterDepartment of Urology, University of WashingtonFred Hutchinson Cancer Research CenterDivision of Gerontology and Geriatric Medicine, University of WashingtonMasonic Cancer Center, University of MinnesotaCastration-resistant prostate cancer frequently presents with persistent androgen receptor signalling. Here, the authors find that the androgen receptor is subject to genetic rearrangements, resulting in variants with ligand-independent activity.https://doi.org/10.1038/ncomms13668 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Christine Henzler Yingming Li Rendong Yang Terri McBride Yeung Ho Cynthia Sprenger Gang Liu Ilsa Coleman Bryce Lakely Rui Li Shihong Ma Sean R. Landman Vipin Kumar Tae Hyun Hwang Ganesh V. Raj Celestia S. Higano Colm Morrissey Peter S. Nelson Stephen R. Plymate Scott M. Dehm |
| spellingShingle |
Christine Henzler Yingming Li Rendong Yang Terri McBride Yeung Ho Cynthia Sprenger Gang Liu Ilsa Coleman Bryce Lakely Rui Li Shihong Ma Sean R. Landman Vipin Kumar Tae Hyun Hwang Ganesh V. Raj Celestia S. Higano Colm Morrissey Peter S. Nelson Stephen R. Plymate Scott M. Dehm Truncation and constitutive activation of the androgen receptor by diverse genomic rearrangements in prostate cancer Nature Communications |
| author_facet |
Christine Henzler Yingming Li Rendong Yang Terri McBride Yeung Ho Cynthia Sprenger Gang Liu Ilsa Coleman Bryce Lakely Rui Li Shihong Ma Sean R. Landman Vipin Kumar Tae Hyun Hwang Ganesh V. Raj Celestia S. Higano Colm Morrissey Peter S. Nelson Stephen R. Plymate Scott M. Dehm |
| author_sort |
Christine Henzler |
| title |
Truncation and constitutive activation of the androgen receptor by diverse genomic rearrangements in prostate cancer |
| title_short |
Truncation and constitutive activation of the androgen receptor by diverse genomic rearrangements in prostate cancer |
| title_full |
Truncation and constitutive activation of the androgen receptor by diverse genomic rearrangements in prostate cancer |
| title_fullStr |
Truncation and constitutive activation of the androgen receptor by diverse genomic rearrangements in prostate cancer |
| title_full_unstemmed |
Truncation and constitutive activation of the androgen receptor by diverse genomic rearrangements in prostate cancer |
| title_sort |
truncation and constitutive activation of the androgen receptor by diverse genomic rearrangements in prostate cancer |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2016-11-01 |
| description |
Castration-resistant prostate cancer frequently presents with persistent androgen receptor signalling. Here, the authors find that the androgen receptor is subject to genetic rearrangements, resulting in variants with ligand-independent activity. |
| url |
https://doi.org/10.1038/ncomms13668 |
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