Plasma biomarkers for amyloid, tau, and cytokines in Down syndrome and sporadic Alzheimer’s disease

Plasma biomarkers for amyloid, tau, and cytokines in Down syndrome and sporadic Alzheimer’s disease

Abstract Background Down syndrome (DS), caused by chromosome 21 trisomy, is associated with an ultra-high risk of dementia due to Alzheimer’s disease (AD), driven by amyloid precursor protein (APP) gene triplication. Understanding relevant molecular differences between those with DS, those with spor...

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Bibliographic Details
Main Authors: Carla M. Startin, Nicholas J. Ashton, Sarah Hamburg, Rosalyn Hithersay, Frances K. Wiseman, Kin Y. Mok, John Hardy, Alberto Lleó, Simon Lovestone, Lucilla Parnetti, Henrik Zetterberg, Abdul Hye, LonDownS Consortium, André Strydom
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Alzheimer’s Research & Therapy
Subjects:
Down syndrome
Alzheimer’s disease
Dementia
Biomarker
Plasma
Amyloid
Online Access:http://link.springer.com/article/10.1186/s13195-019-0477-0

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