Effect of SMILE-derived decellularized lenticules as an adhesion barrier in a rabbit model of glaucoma filtration surgery
Abstract Background To investigate the effects of small incision lenticule extraction (SMILE)-derived decellularized lenticules on intraocular pressure (IOP) and conjunctival scarring in a rabbit model of glaucoma filtration surgery. Methods Trabeculectomy was performed on both eyes of New Zealand r...
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doaj-88275273ada2452facd889b715a54e332021-09-12T12:10:03ZengBMCBMC Ophthalmology1471-24152021-09-012111710.1186/s12886-021-02090-3Effect of SMILE-derived decellularized lenticules as an adhesion barrier in a rabbit model of glaucoma filtration surgeryHoufa Yin0Xinyi Chen1Xiaogang Hong2Jian Ma3Fang Wu4Ting Wan5Yiwen Sang6Qiuli Fu7Zhenwei Qin8Danni Lyu9Wei Wu10Jinfu Yin11Yabo Yang12Eye Center, the Second Affiliated Hospital, Zhejiang University School of MedicineEye Center, the Second Affiliated Hospital, Zhejiang University School of MedicineDepartment of Ophthalmology, People’s Hospital of KaihuaEye Center, the Second Affiliated Hospital, Zhejiang University School of MedicineEye Center, the Second Affiliated Hospital, Zhejiang University School of MedicineEye Center, the Second Affiliated Hospital, Zhejiang University School of MedicineDepartment of Laboratory Medicine, the Second Affiliated Hospital, Zhejiang University School of MedicineEye Center, the Second Affiliated Hospital, Zhejiang University School of MedicineEye Center, the Second Affiliated Hospital, Zhejiang University School of MedicineEye Center, the Second Affiliated Hospital, Zhejiang University School of MedicineEye Center, the Second Affiliated Hospital, Zhejiang University School of MedicineEye Center, the Second Affiliated Hospital, Zhejiang University School of MedicineEye Center, the Second Affiliated Hospital, Zhejiang University School of MedicineAbstract Background To investigate the effects of small incision lenticule extraction (SMILE)-derived decellularized lenticules on intraocular pressure (IOP) and conjunctival scarring in a rabbit model of glaucoma filtration surgery. Methods Trabeculectomy was performed on both eyes of New Zealand rabbits. A decellularized lenticule was placed in the subconjunctival space in one eye of the rabbits (the decellularized lenticule group), and no adjunctive treatment was performed in the fellow eye (the control group). The filtering bleb features and IOP were evaluated 0, 3, 7, 14, 21, and 28 days after surgery, and histopathologic examination was performed 28 days after surgery. Results Decellularized lenticules significantly increased bleb survival and decreased IOP postoperatively in the rabbit model with no adverse side effects. The histopathologic results showed a larger subconjunctival space and less subconjunctival fibrosis in the decellularized lenticule group. Conclusions Decellularized lenticules can prevent postoperative conjunctiva-sclera adhesion and fibrosis, and they may represent a novel antifibrotic agent for trabeculectomy.https://doi.org/10.1186/s12886-021-02090-3SMILEDecellularized lenticuleAdhesion barrierGlaucomaTrabeculectomy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Houfa Yin Xinyi Chen Xiaogang Hong Jian Ma Fang Wu Ting Wan Yiwen Sang Qiuli Fu Zhenwei Qin Danni Lyu Wei Wu Jinfu Yin Yabo Yang |
spellingShingle |
Houfa Yin Xinyi Chen Xiaogang Hong Jian Ma Fang Wu Ting Wan Yiwen Sang Qiuli Fu Zhenwei Qin Danni Lyu Wei Wu Jinfu Yin Yabo Yang Effect of SMILE-derived decellularized lenticules as an adhesion barrier in a rabbit model of glaucoma filtration surgery BMC Ophthalmology SMILE Decellularized lenticule Adhesion barrier Glaucoma Trabeculectomy |
author_facet |
Houfa Yin Xinyi Chen Xiaogang Hong Jian Ma Fang Wu Ting Wan Yiwen Sang Qiuli Fu Zhenwei Qin Danni Lyu Wei Wu Jinfu Yin Yabo Yang |
author_sort |
Houfa Yin |
title |
Effect of SMILE-derived decellularized lenticules as an adhesion barrier in a rabbit model of glaucoma filtration surgery |
title_short |
Effect of SMILE-derived decellularized lenticules as an adhesion barrier in a rabbit model of glaucoma filtration surgery |
title_full |
Effect of SMILE-derived decellularized lenticules as an adhesion barrier in a rabbit model of glaucoma filtration surgery |
title_fullStr |
Effect of SMILE-derived decellularized lenticules as an adhesion barrier in a rabbit model of glaucoma filtration surgery |
title_full_unstemmed |
Effect of SMILE-derived decellularized lenticules as an adhesion barrier in a rabbit model of glaucoma filtration surgery |
title_sort |
effect of smile-derived decellularized lenticules as an adhesion barrier in a rabbit model of glaucoma filtration surgery |
publisher |
BMC |
series |
BMC Ophthalmology |
issn |
1471-2415 |
publishDate |
2021-09-01 |
description |
Abstract Background To investigate the effects of small incision lenticule extraction (SMILE)-derived decellularized lenticules on intraocular pressure (IOP) and conjunctival scarring in a rabbit model of glaucoma filtration surgery. Methods Trabeculectomy was performed on both eyes of New Zealand rabbits. A decellularized lenticule was placed in the subconjunctival space in one eye of the rabbits (the decellularized lenticule group), and no adjunctive treatment was performed in the fellow eye (the control group). The filtering bleb features and IOP were evaluated 0, 3, 7, 14, 21, and 28 days after surgery, and histopathologic examination was performed 28 days after surgery. Results Decellularized lenticules significantly increased bleb survival and decreased IOP postoperatively in the rabbit model with no adverse side effects. The histopathologic results showed a larger subconjunctival space and less subconjunctival fibrosis in the decellularized lenticule group. Conclusions Decellularized lenticules can prevent postoperative conjunctiva-sclera adhesion and fibrosis, and they may represent a novel antifibrotic agent for trabeculectomy. |
topic |
SMILE Decellularized lenticule Adhesion barrier Glaucoma Trabeculectomy |
url |
https://doi.org/10.1186/s12886-021-02090-3 |
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