Disrupted functional connectivity of striatal sub-regions in Bell's palsy patients
The striatum plays an important role in controlling motor function in humans, and its degeneration has the ability to cause severe motor disorders. More specifically, previous studies have demonstrated a disruption in the connectivity of the cortico-striatal loop in patients suffering from motor dis...
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doaj-8838470031fc4abca0f099a197d6d8732020-11-24T23:13:32ZengElsevierNeuroImage: Clinical2213-15822017-01-0114C12212910.1016/j.nicl.2017.01.008Disrupted functional connectivity of striatal sub-regions in Bell's palsy patientsWenwen Song0Zhijian Cao1Courtney Lang2Minhui Dai3Lihua Xuan4Kun Lv5Fangyuan Cui6Kristen Jorgenson7Maosheng Xu8Jian Kong9The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, ChinaThe First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, ChinaDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USAThe First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, ChinaThe First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, ChinaThe First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, ChinaDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USADepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USAThe First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, ChinaThe First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, ChinaThe striatum plays an important role in controlling motor function in humans, and its degeneration has the ability to cause severe motor disorders. More specifically, previous studies have demonstrated a disruption in the connectivity of the cortico-striatal loop in patients suffering from motor disorders caused by dopamine dysregulation, such as Parkinson's disease. However, little is known about striatal functional connectivity in patients with motor dysfunction not caused by dopamine dysregulation. In this study, we used early-state Bell's palsy (BP) patients (within 14 days of onset) to investigate how functional connectivity between the striatum and motor cortex is affected by peripheral nerve injury in which the dopamine system remains fully functional. We found a significant increase in the connectivity between the contralateral putamen, and the ipsilateral primary sensory (S1) and motor cortex (M1) in BP patients compared to healthy controls. We also found increased connectivity between the ventral striatum and supplementary motor area (SMA), and the dorsal caudate and medial prefrontal lobe in BP patients compared to healthy controls. Our results demonstrate that the entirety of the striatum is affected following acute peripheral nerve injury, and suggests that this disrupted striatal functional connectivity may reflect a compensatory mechanism for the sensory-motor mismatch caused by BP.http://www.sciencedirect.com/science/article/pii/S2213158217300086Bell's palsyStriatumFunctional connectivityMotor disorder |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Wenwen Song Zhijian Cao Courtney Lang Minhui Dai Lihua Xuan Kun Lv Fangyuan Cui Kristen Jorgenson Maosheng Xu Jian Kong |
spellingShingle |
Wenwen Song Zhijian Cao Courtney Lang Minhui Dai Lihua Xuan Kun Lv Fangyuan Cui Kristen Jorgenson Maosheng Xu Jian Kong Disrupted functional connectivity of striatal sub-regions in Bell's palsy patients NeuroImage: Clinical Bell's palsy Striatum Functional connectivity Motor disorder |
author_facet |
Wenwen Song Zhijian Cao Courtney Lang Minhui Dai Lihua Xuan Kun Lv Fangyuan Cui Kristen Jorgenson Maosheng Xu Jian Kong |
author_sort |
Wenwen Song |
title |
Disrupted functional connectivity of striatal sub-regions in Bell's palsy patients |
title_short |
Disrupted functional connectivity of striatal sub-regions in Bell's palsy patients |
title_full |
Disrupted functional connectivity of striatal sub-regions in Bell's palsy patients |
title_fullStr |
Disrupted functional connectivity of striatal sub-regions in Bell's palsy patients |
title_full_unstemmed |
Disrupted functional connectivity of striatal sub-regions in Bell's palsy patients |
title_sort |
disrupted functional connectivity of striatal sub-regions in bell's palsy patients |
publisher |
Elsevier |
series |
NeuroImage: Clinical |
issn |
2213-1582 |
publishDate |
2017-01-01 |
description |
The striatum plays an important role in controlling motor function in humans, and its degeneration has the ability to cause severe motor disorders. More specifically, previous studies have demonstrated a disruption in the connectivity of the cortico-striatal loop in patients suffering from motor disorders caused by dopamine dysregulation, such as Parkinson's disease. However, little is known about striatal functional connectivity in patients with motor dysfunction not caused by dopamine dysregulation. In this study, we used early-state Bell's palsy (BP) patients (within 14 days of onset) to investigate how functional connectivity between the striatum and motor cortex is affected by peripheral nerve injury in which the dopamine system remains fully functional. We found a significant increase in the connectivity between the contralateral putamen, and the ipsilateral primary sensory (S1) and motor cortex (M1) in BP patients compared to healthy controls. We also found increased connectivity between the ventral striatum and supplementary motor area (SMA), and the dorsal caudate and medial prefrontal lobe in BP patients compared to healthy controls. Our results demonstrate that the entirety of the striatum is affected following acute peripheral nerve injury, and suggests that this disrupted striatal functional connectivity may reflect a compensatory mechanism for the sensory-motor mismatch caused by BP. |
topic |
Bell's palsy Striatum Functional connectivity Motor disorder |
url |
http://www.sciencedirect.com/science/article/pii/S2213158217300086 |
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