Ochratoxin A: its impact on poultry gut health and microbiota, an overview
Ochratoxin A (OTA) is a widespread mycotoxin, that has strong thermal stability, and is difficult to remove from feed. OTA is nephrotoxic, hepatotoxic, teratogenic, immunotoxic, and enterotoxic to several species of animals. The gut is the first defense barrier against various types of mycotoxins pr...
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doaj-883a148655d1438e98cb9f0f59dc36f52021-04-24T05:55:43ZengElsevierPoultry Science0032-57912021-05-011005101037Ochratoxin A: its impact on poultry gut health and microbiota, an overviewShuangshuang Zhai0Yongwen Zhu1Peishi Feng2Macheng Li3Wence Wang4Lin Yang5Ye Yang6College of Animal Science, Yangtze University, Jingzhou 434000, ChinaGuangdong Provincial Key Laboratory of Animal Nutrition and Regulation, College of Animal Science, South China Agricultural University, Guangzhou 510000, ChinaPharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, ChinaResearch and Development department, Hunan Microorganism & Herb Biological Feed Technology Co., Ltd., Xiangtan 411100, ChinaGuangdong Provincial Key Laboratory of Animal Nutrition and Regulation, College of Animal Science, South China Agricultural University, Guangzhou 510000, ChinaGuangdong Provincial Key Laboratory of Animal Nutrition and Regulation, College of Animal Science, South China Agricultural University, Guangzhou 510000, ChinaCollege of Animal Science, Yangtze University, Jingzhou 434000, China; Corresponding author:Ochratoxin A (OTA) is a widespread mycotoxin, that has strong thermal stability, and is difficult to remove from feed. OTA is nephrotoxic, hepatotoxic, teratogenic, immunotoxic, and enterotoxic to several species of animals. The gut is the first defense barrier against various types of mycotoxins present in feed that enter the body, and it is closely connected to other tissues through enterohepatic circulation. Compared with mammals, poultry is more sensitive to OTA and has a lower absorption rate. Therefore, the gut is an important target tissue for OTA in poultry. This review comprehensively discusses the role of OTA in gut health and the gut microbiota of poultry, focusing on the effect of OTA on digestive and absorptive processes, intestinal barrier integrity, intestinal histomorphology, gut immunity, and gut microbiota. According to the studies described to date, OTA can affect gut dysbiosis, including increasing gut permeability, immunity, and bacterial translocation, and can eventually lead to gut and other organ injury. Although there are many studies investigating the effects of OTA on the gut health of poultry, further studies are needed to better characterize the underlying mechanisms of action and develop preventative or therapeutic interventions for mycotoxicosis in poultry.http://www.sciencedirect.com/science/article/pii/S0032579121000717ochratoxin Apoultrytight junctionimmunitygut microbiota |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Shuangshuang Zhai Yongwen Zhu Peishi Feng Macheng Li Wence Wang Lin Yang Ye Yang |
spellingShingle |
Shuangshuang Zhai Yongwen Zhu Peishi Feng Macheng Li Wence Wang Lin Yang Ye Yang Ochratoxin A: its impact on poultry gut health and microbiota, an overview Poultry Science ochratoxin A poultry tight junction immunity gut microbiota |
author_facet |
Shuangshuang Zhai Yongwen Zhu Peishi Feng Macheng Li Wence Wang Lin Yang Ye Yang |
author_sort |
Shuangshuang Zhai |
title |
Ochratoxin A: its impact on poultry gut health and microbiota, an overview |
title_short |
Ochratoxin A: its impact on poultry gut health and microbiota, an overview |
title_full |
Ochratoxin A: its impact on poultry gut health and microbiota, an overview |
title_fullStr |
Ochratoxin A: its impact on poultry gut health and microbiota, an overview |
title_full_unstemmed |
Ochratoxin A: its impact on poultry gut health and microbiota, an overview |
title_sort |
ochratoxin a: its impact on poultry gut health and microbiota, an overview |
publisher |
Elsevier |
series |
Poultry Science |
issn |
0032-5791 |
publishDate |
2021-05-01 |
description |
Ochratoxin A (OTA) is a widespread mycotoxin, that has strong thermal stability, and is difficult to remove from feed. OTA is nephrotoxic, hepatotoxic, teratogenic, immunotoxic, and enterotoxic to several species of animals. The gut is the first defense barrier against various types of mycotoxins present in feed that enter the body, and it is closely connected to other tissues through enterohepatic circulation. Compared with mammals, poultry is more sensitive to OTA and has a lower absorption rate. Therefore, the gut is an important target tissue for OTA in poultry. This review comprehensively discusses the role of OTA in gut health and the gut microbiota of poultry, focusing on the effect of OTA on digestive and absorptive processes, intestinal barrier integrity, intestinal histomorphology, gut immunity, and gut microbiota. According to the studies described to date, OTA can affect gut dysbiosis, including increasing gut permeability, immunity, and bacterial translocation, and can eventually lead to gut and other organ injury. Although there are many studies investigating the effects of OTA on the gut health of poultry, further studies are needed to better characterize the underlying mechanisms of action and develop preventative or therapeutic interventions for mycotoxicosis in poultry. |
topic |
ochratoxin A poultry tight junction immunity gut microbiota |
url |
http://www.sciencedirect.com/science/article/pii/S0032579121000717 |
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