Lack of riluzole efficacy in the progression of the neurodegenerative phenotype in a new conditional mouse model of striatal degeneration

Lack of riluzole efficacy in the progression of the neurodegenerative phenotype in a new conditional mouse model of striatal degeneration

Background Huntington’s disease (HD) is a rare familial autosomal dominant neurodegenerative disorder characterized by progressive degeneration of medium spiny neurons (MSNs) located in the striatum. Currently available treatments of HD are only limited to alleviating symptoms; therefore, high expec...

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Bibliographic Details
Main Authors: Grzegorz Kreiner, Katarzyna Rafa-Zabłocka, Piotr Chmielarz, Monika Bagińska, Irena Nalepa
Format: Article
Language:English
Published: PeerJ Inc. 2017-04-01
Series:PeerJ
Subjects:
Riluzole
Neurodegeneration
Huntington’s disease
Transgenic models
Neurogenesis
Neuroprotection
Online Access:https://peerj.com/articles/3240.pdf

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https://peerj.com/articles/3240.pdf

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