Diagnostic Performance of <sup>18</sup>F-FDG PET or PET/CT for Detection of Post-Transplant Lymphoproliferative Disorder: A Systematic Review and a Bivariate Meta-Analysis

Background: Some studies evaluated the diagnostic performance of fluorine-18-fluorodeoxyglucose (<sup>18</sup>F-FDG) positron emission tomography or positron emission tomography/computed tomography (PET or PET/CT) for the detection of post-transplant lymphoproliferative disorder (PTLD)....

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Main Authors: Veronika Ballova, Barbara Muoio, Domenico Albano, Francesco Bertagna, Luca Canziani, Michele Ghielmini, Luca Ceriani, Giorgio Treglia
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Diagnostics
Subjects:
pet
Online Access:https://www.mdpi.com/2075-4418/10/2/101
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spelling doaj-884e3ee157a947ca84c33f2197c0bc302020-11-25T02:20:44ZengMDPI AGDiagnostics2075-44182020-02-0110210110.3390/diagnostics10020101diagnostics10020101Diagnostic Performance of <sup>18</sup>F-FDG PET or PET/CT for Detection of Post-Transplant Lymphoproliferative Disorder: A Systematic Review and a Bivariate Meta-AnalysisVeronika Ballova0Barbara Muoio1Domenico Albano2Francesco Bertagna3Luca Canziani4Michele Ghielmini5Luca Ceriani6Giorgio Treglia7Department of Oncology and Hematology, Cantonal Hospital Baden, CH-5404 Baden, SwitzerlandClinic of Medical Oncology, Oncology Institute of Southern Switzerland, Ente Ospedaliero Cantonale, CH-6500 Bellinzona, SwitzerlandNuclear Medicine, University of Brescia and Spedali Civili Brescia, IT-25123 Brescia, ItalyNuclear Medicine, University of Brescia and Spedali Civili Brescia, IT-25123 Brescia, ItalyDepartment of Haematology and Oncology, Niguarda Hospital, IT-20162 Milan, ItalyAcademic Education Research and Innovation Area, General Directorate, Ente Ospedaliero Cantonale, CH-6500 Bellinzona, SwitzerlandClinic of Nuclear Medicine and Molecular Imaging, Imaging Institute of Southern Switzerland, Ente Ospedaliero Cantonale, CH-6900 Lugano, SwitzerlandAcademic Education Research and Innovation Area, General Directorate, Ente Ospedaliero Cantonale, CH-6500 Bellinzona, SwitzerlandBackground: Some studies evaluated the diagnostic performance of fluorine-18-fluorodeoxyglucose (<sup>18</sup>F-FDG) positron emission tomography or positron emission tomography/computed tomography (PET or PET/CT) for the detection of post-transplant lymphoproliferative disorder (PTLD). As there is no clear consensus about the diagnostic accuracy of these imaging methods, we performed a meta-analysis on this topic. Methods: A comprehensive computer literature search of PubMed, Embase, and Cochrane library databases through December 2019 was performed. Pooled sensitivity, specificity, positive and negative likelihood ratios (LR+ and LR&#8722;), and diagnostic odds ratio (DOR) of <sup>18</sup>F-FDG PET or PET/CT for detection of PTLD were calculated. Results: Five studies reporting data on the diagnostic performance of <sup>18</sup>F-FDG PET or PET/CT in 336 transplant recipients were included in the systematic review and bivariate meta-analysis. Pooled sensitivity and specificity for detection of PTLD were 89.7% (95% confidence interval (95%CI): 84.6&#8722;93.2%) and 90.9% (95%CI: 85.9&#8722;94.3%), respectively. Pooled LR+, LR&#8722;, and DOR were 8.9 (95%CI: 5.7&#8722;14), 0.13 (95%CI: 0.08&#8722;0.2), and 70.4 (95%CI: 35.4&#8722;140), respectively. A significant heterogeneity among studies was not detected. Conclusions: Despite limited literature data, <sup>18</sup>F-FDG PET or PET/CT demonstrated good diagnostic performance for the detection of PTLD, but large prospective studies are needed to strengthen these findings.https://www.mdpi.com/2075-4418/10/2/101pet<sup>18</sup>f-fdgptldlymphomapost-transplant lymphoproliferative disordermeta-analysis
collection DOAJ
language English
format Article
sources DOAJ
author Veronika Ballova
Barbara Muoio
Domenico Albano
Francesco Bertagna
Luca Canziani
Michele Ghielmini
Luca Ceriani
Giorgio Treglia
spellingShingle Veronika Ballova
Barbara Muoio
Domenico Albano
Francesco Bertagna
Luca Canziani
Michele Ghielmini
Luca Ceriani
Giorgio Treglia
Diagnostic Performance of <sup>18</sup>F-FDG PET or PET/CT for Detection of Post-Transplant Lymphoproliferative Disorder: A Systematic Review and a Bivariate Meta-Analysis
Diagnostics
pet
<sup>18</sup>f-fdg
ptld
lymphoma
post-transplant lymphoproliferative disorder
meta-analysis
author_facet Veronika Ballova
Barbara Muoio
Domenico Albano
Francesco Bertagna
Luca Canziani
Michele Ghielmini
Luca Ceriani
Giorgio Treglia
author_sort Veronika Ballova
title Diagnostic Performance of <sup>18</sup>F-FDG PET or PET/CT for Detection of Post-Transplant Lymphoproliferative Disorder: A Systematic Review and a Bivariate Meta-Analysis
title_short Diagnostic Performance of <sup>18</sup>F-FDG PET or PET/CT for Detection of Post-Transplant Lymphoproliferative Disorder: A Systematic Review and a Bivariate Meta-Analysis
title_full Diagnostic Performance of <sup>18</sup>F-FDG PET or PET/CT for Detection of Post-Transplant Lymphoproliferative Disorder: A Systematic Review and a Bivariate Meta-Analysis
title_fullStr Diagnostic Performance of <sup>18</sup>F-FDG PET or PET/CT for Detection of Post-Transplant Lymphoproliferative Disorder: A Systematic Review and a Bivariate Meta-Analysis
title_full_unstemmed Diagnostic Performance of <sup>18</sup>F-FDG PET or PET/CT for Detection of Post-Transplant Lymphoproliferative Disorder: A Systematic Review and a Bivariate Meta-Analysis
title_sort diagnostic performance of <sup>18</sup>f-fdg pet or pet/ct for detection of post-transplant lymphoproliferative disorder: a systematic review and a bivariate meta-analysis
publisher MDPI AG
series Diagnostics
issn 2075-4418
publishDate 2020-02-01
description Background: Some studies evaluated the diagnostic performance of fluorine-18-fluorodeoxyglucose (<sup>18</sup>F-FDG) positron emission tomography or positron emission tomography/computed tomography (PET or PET/CT) for the detection of post-transplant lymphoproliferative disorder (PTLD). As there is no clear consensus about the diagnostic accuracy of these imaging methods, we performed a meta-analysis on this topic. Methods: A comprehensive computer literature search of PubMed, Embase, and Cochrane library databases through December 2019 was performed. Pooled sensitivity, specificity, positive and negative likelihood ratios (LR+ and LR&#8722;), and diagnostic odds ratio (DOR) of <sup>18</sup>F-FDG PET or PET/CT for detection of PTLD were calculated. Results: Five studies reporting data on the diagnostic performance of <sup>18</sup>F-FDG PET or PET/CT in 336 transplant recipients were included in the systematic review and bivariate meta-analysis. Pooled sensitivity and specificity for detection of PTLD were 89.7% (95% confidence interval (95%CI): 84.6&#8722;93.2%) and 90.9% (95%CI: 85.9&#8722;94.3%), respectively. Pooled LR+, LR&#8722;, and DOR were 8.9 (95%CI: 5.7&#8722;14), 0.13 (95%CI: 0.08&#8722;0.2), and 70.4 (95%CI: 35.4&#8722;140), respectively. A significant heterogeneity among studies was not detected. Conclusions: Despite limited literature data, <sup>18</sup>F-FDG PET or PET/CT demonstrated good diagnostic performance for the detection of PTLD, but large prospective studies are needed to strengthen these findings.
topic pet
<sup>18</sup>f-fdg
ptld
lymphoma
post-transplant lymphoproliferative disorder
meta-analysis
url https://www.mdpi.com/2075-4418/10/2/101
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