Acute stress enhances adult rat hippocampal neurogenesis and activation of newborn neurons via secreted astrocytic FGF2

Stress is a potent modulator of the mammalian brain. The highly conserved stress hormone response influences many brain regions, particularly the hippocampus, a region important for memory function. The effect of acute stress on the unique population of adult neural stem/progenitor cells (NPCs) that...

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Main Authors:	Elizabeth D Kirby, Sandra E Muroy, Wayne G Sun, David Covarrubias, Megan J Leong, Laurel A Barchas, Daniela Kaufer
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2013-04-01
Series:	eLife
Subjects:	neurogenesis stress hippocampus FGF2 astrocyte stem cell
Online Access:	https://elifesciences.org/articles/00362

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record_format	Article
spelling	doaj-88638b7501c74e9893b1b8a70779fd2d2021-05-04T22:26:10ZengeLife Sciences Publications LtdeLife2050-084X2013-04-01210.7554/eLife.00362Acute stress enhances adult rat hippocampal neurogenesis and activation of newborn neurons via secreted astrocytic FGF2Elizabeth D Kirby0Sandra E Muroy1Wayne G Sun2David Covarrubias3Megan J Leong4Laurel A Barchas5Daniela Kaufer6Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, United StatesDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United StatesDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United StatesDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United StatesHelen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, United StatesDepartment of Integrative Biology, University of California, Berkeley, Berkeley, United StatesHelen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, United States; Department of Integrative Biology, University of California, Berkeley, Berkeley, United StatesStress is a potent modulator of the mammalian brain. The highly conserved stress hormone response influences many brain regions, particularly the hippocampus, a region important for memory function. The effect of acute stress on the unique population of adult neural stem/progenitor cells (NPCs) that resides in the adult hippocampus is unclear. We found that acute stress increased hippocampal cell proliferation and astrocytic fibroblast growth factor 2 (FGF2) expression. The effect of acute stress occurred independent of basolateral amygdala neural input and was mimicked by treating isolated NPCs with conditioned media from corticosterone-treated primary astrocytes. Neutralization of FGF2 revealed that astrocyte-secreted FGF2 mediated stress-hormone-induced NPC proliferation. 2 weeks, but not 2 days, after acute stress, rats also showed enhanced fear extinction memory coincident with enhanced activation of newborn neurons. Our findings suggest a beneficial role for brief stress on the hippocampus and improve understanding of the adaptive capacity of the brain.https://elifesciences.org/articles/00362neurogenesisstresshippocampusFGF2astrocytestem cell
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Elizabeth D Kirby Sandra E Muroy Wayne G Sun David Covarrubias Megan J Leong Laurel A Barchas Daniela Kaufer
spellingShingle	Elizabeth D Kirby Sandra E Muroy Wayne G Sun David Covarrubias Megan J Leong Laurel A Barchas Daniela Kaufer Acute stress enhances adult rat hippocampal neurogenesis and activation of newborn neurons via secreted astrocytic FGF2 eLife neurogenesis stress hippocampus FGF2 astrocyte stem cell
author_facet	Elizabeth D Kirby Sandra E Muroy Wayne G Sun David Covarrubias Megan J Leong Laurel A Barchas Daniela Kaufer
author_sort	Elizabeth D Kirby
title	Acute stress enhances adult rat hippocampal neurogenesis and activation of newborn neurons via secreted astrocytic FGF2
title_short	Acute stress enhances adult rat hippocampal neurogenesis and activation of newborn neurons via secreted astrocytic FGF2
title_full	Acute stress enhances adult rat hippocampal neurogenesis and activation of newborn neurons via secreted astrocytic FGF2
title_fullStr	Acute stress enhances adult rat hippocampal neurogenesis and activation of newborn neurons via secreted astrocytic FGF2
title_full_unstemmed	Acute stress enhances adult rat hippocampal neurogenesis and activation of newborn neurons via secreted astrocytic FGF2
title_sort	acute stress enhances adult rat hippocampal neurogenesis and activation of newborn neurons via secreted astrocytic fgf2
publisher	eLife Sciences Publications Ltd
series	eLife
issn	2050-084X
publishDate	2013-04-01
description	Stress is a potent modulator of the mammalian brain. The highly conserved stress hormone response influences many brain regions, particularly the hippocampus, a region important for memory function. The effect of acute stress on the unique population of adult neural stem/progenitor cells (NPCs) that resides in the adult hippocampus is unclear. We found that acute stress increased hippocampal cell proliferation and astrocytic fibroblast growth factor 2 (FGF2) expression. The effect of acute stress occurred independent of basolateral amygdala neural input and was mimicked by treating isolated NPCs with conditioned media from corticosterone-treated primary astrocytes. Neutralization of FGF2 revealed that astrocyte-secreted FGF2 mediated stress-hormone-induced NPC proliferation. 2 weeks, but not 2 days, after acute stress, rats also showed enhanced fear extinction memory coincident with enhanced activation of newborn neurons. Our findings suggest a beneficial role for brief stress on the hippocampus and improve understanding of the adaptive capacity of the brain.
topic	neurogenesis stress hippocampus FGF2 astrocyte stem cell
url	https://elifesciences.org/articles/00362
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Acute stress enhances adult rat hippocampal neurogenesis and activation of newborn neurons via secreted astrocytic FGF2

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