Use of Microbiota to Fight Mosquito-Borne Disease

Use of Microbiota to Fight Mosquito-Borne Disease

Mosquito-borne diseases cause more than 700 million people infected and one million people die (Caraballo and King, 2014). With the limitations of progress toward elimination imposed by insecticide- and drug-resistance, combined with the lack of vaccines, innovative strategies to fight mosquito-born...

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Bibliographic Details
Main Authors: Wei Huang, Sibao Wang, Marcelo Jacobs-Lorena
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Genetics
Subjects:
insect microbiota
arboviruses
malaria
paratransgenesis
mosquito-pathogen interactions
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2020.00196/full
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spelling doaj-887a8300c2c84e4a9b22ec8dcc645a262020-11-25T02:09:40ZengFrontiers Media S.A.Frontiers in Genetics1664-80212020-03-011110.3389/fgene.2020.00196481121Use of Microbiota to Fight Mosquito-Borne DiseaseWei Huang0Sibao Wang1Marcelo Jacobs-Lorena2Department of Molecular Microbiology and Immunology, Johns Hopkins Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United StatesCAS Key Laboratory of Insect Developmental and Evolutionary Biology, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, ChinaDepartment of Molecular Microbiology and Immunology, Johns Hopkins Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United StatesMosquito-borne diseases cause more than 700 million people infected and one million people die (Caraballo and King, 2014). With the limitations of progress toward elimination imposed by insecticide- and drug-resistance, combined with the lack of vaccines, innovative strategies to fight mosquito-borne disease are urgently needed. In recent years, the use of mosquito microbiota has shown great potential for cutting down transmission of mosquito-borne pathogens. Here we review what is known about the mosquito microbiota and how this knowledge is being used to develop new ways to control mosquito-borne disease. We also discuss the challenges for the eventual release of genetically modified (GM) symbionts in the field.https://www.frontiersin.org/article/10.3389/fgene.2020.00196/fullinsect microbiotaarbovirusesmalariaparatransgenesismosquito-pathogen interactions
collection DOAJ
language English
format Article
sources DOAJ
author Wei Huang
Sibao Wang
Marcelo Jacobs-Lorena
spellingShingle Wei Huang
Sibao Wang
Marcelo Jacobs-Lorena
Use of Microbiota to Fight Mosquito-Borne Disease
Frontiers in Genetics
insect microbiota
arboviruses
malaria
paratransgenesis
mosquito-pathogen interactions
author_facet Wei Huang
Sibao Wang
Marcelo Jacobs-Lorena
author_sort Wei Huang
title Use of Microbiota to Fight Mosquito-Borne Disease
title_short Use of Microbiota to Fight Mosquito-Borne Disease
title_full Use of Microbiota to Fight Mosquito-Borne Disease
title_fullStr Use of Microbiota to Fight Mosquito-Borne Disease
title_full_unstemmed Use of Microbiota to Fight Mosquito-Borne Disease
title_sort use of microbiota to fight mosquito-borne disease
publisher Frontiers Media S.A.
series Frontiers in Genetics
issn 1664-8021
publishDate 2020-03-01
description Mosquito-borne diseases cause more than 700 million people infected and one million people die (Caraballo and King, 2014). With the limitations of progress toward elimination imposed by insecticide- and drug-resistance, combined with the lack of vaccines, innovative strategies to fight mosquito-borne disease are urgently needed. In recent years, the use of mosquito microbiota has shown great potential for cutting down transmission of mosquito-borne pathogens. Here we review what is known about the mosquito microbiota and how this knowledge is being used to develop new ways to control mosquito-borne disease. We also discuss the challenges for the eventual release of genetically modified (GM) symbionts in the field.
topic insect microbiota
arboviruses
malaria
paratransgenesis
mosquito-pathogen interactions
url https://www.frontiersin.org/article/10.3389/fgene.2020.00196/full
work_keys_str_mv AT weihuang useofmicrobiotatofightmosquitobornedisease
AT sibaowang useofmicrobiotatofightmosquitobornedisease
AT marcelojacobslorena useofmicrobiotatofightmosquitobornedisease
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