Generation of an integration-free induced pluripotent stem cell (iPSC) line (ZZUNEUi005-A) from a Wilson's disease patient harboring a homozygous Pro992Leu mutation in ATP7B gene

Generation of an integration-free induced pluripotent stem cell (iPSC) line (ZZUNEUi005-A) from a Wilson's disease patient harboring a homozygous Pro992Leu mutation in ATP7B gene

Using non-integrative reprogramming method, a human induced pluripotent stem cell (iPSC) line, ZZUNEUi005-A, was generated from a 36-year-old male patient with Wilson’s disease, carrying a homozygous Pro992Leu mutation in the ATP7B gene. This cell line shows pluripotency both in vitro and in vivo an...

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Main Authors: Liting Wei, Jiwei Zhang, Dingbang Chen, Li Feng, Chao Wu, Rui Wang, Xunhua Li
Format: Article
Language:English
Published: Elsevier 2020-08-01
Series:Stem Cell Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506120302105
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spelling doaj-88849b22766e49539cf01f40ccab9e712020-11-25T03:56:17ZengElsevierStem Cell Research1873-50612020-08-0147101909Generation of an integration-free induced pluripotent stem cell (iPSC) line (ZZUNEUi005-A) from a Wilson's disease patient harboring a homozygous Pro992Leu mutation in ATP7B geneLiting Wei0Jiwei Zhang1Dingbang Chen2Li Feng3Chao Wu4Rui Wang5Xunhua Li6Department of Neurology, Luoyang Central Hospital Affiliated to Zhengzhou University, Luoyang, Henan 467500, ChinaDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan 450052, China; Corresponding authors.Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, ChinaDepartment of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, ChinaDepartment of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, ChinaGuangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong 510530, ChinaDepartment of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, China; Corresponding authors.Using non-integrative reprogramming method, a human induced pluripotent stem cell (iPSC) line, ZZUNEUi005-A, was generated from a 36-year-old male patient with Wilson’s disease, carrying a homozygous Pro992Leu mutation in the ATP7B gene. This cell line shows pluripotency both in vitro and in vivo and has a normal karyotype. Furthermore, we showed that this iPSC line could be differentiated into neural and hepatocyte-like cells.http://www.sciencedirect.com/science/article/pii/S1873506120302105
collection DOAJ
language English
format Article
sources DOAJ
author Liting Wei
Jiwei Zhang
Dingbang Chen
Li Feng
Chao Wu
Rui Wang
Xunhua Li
spellingShingle Liting Wei
Jiwei Zhang
Dingbang Chen
Li Feng
Chao Wu
Rui Wang
Xunhua Li
Generation of an integration-free induced pluripotent stem cell (iPSC) line (ZZUNEUi005-A) from a Wilson's disease patient harboring a homozygous Pro992Leu mutation in ATP7B gene
Stem Cell Research
author_facet Liting Wei
Jiwei Zhang
Dingbang Chen
Li Feng
Chao Wu
Rui Wang
Xunhua Li
author_sort Liting Wei
title Generation of an integration-free induced pluripotent stem cell (iPSC) line (ZZUNEUi005-A) from a Wilson's disease patient harboring a homozygous Pro992Leu mutation in ATP7B gene
title_short Generation of an integration-free induced pluripotent stem cell (iPSC) line (ZZUNEUi005-A) from a Wilson's disease patient harboring a homozygous Pro992Leu mutation in ATP7B gene
title_full Generation of an integration-free induced pluripotent stem cell (iPSC) line (ZZUNEUi005-A) from a Wilson's disease patient harboring a homozygous Pro992Leu mutation in ATP7B gene
title_fullStr Generation of an integration-free induced pluripotent stem cell (iPSC) line (ZZUNEUi005-A) from a Wilson's disease patient harboring a homozygous Pro992Leu mutation in ATP7B gene
title_full_unstemmed Generation of an integration-free induced pluripotent stem cell (iPSC) line (ZZUNEUi005-A) from a Wilson's disease patient harboring a homozygous Pro992Leu mutation in ATP7B gene
title_sort generation of an integration-free induced pluripotent stem cell (ipsc) line (zzuneui005-a) from a wilson's disease patient harboring a homozygous pro992leu mutation in atp7b gene
publisher Elsevier
series Stem Cell Research
issn 1873-5061
publishDate 2020-08-01
description Using non-integrative reprogramming method, a human induced pluripotent stem cell (iPSC) line, ZZUNEUi005-A, was generated from a 36-year-old male patient with Wilson’s disease, carrying a homozygous Pro992Leu mutation in the ATP7B gene. This cell line shows pluripotency both in vitro and in vivo and has a normal karyotype. Furthermore, we showed that this iPSC line could be differentiated into neural and hepatocyte-like cells.
url http://www.sciencedirect.com/science/article/pii/S1873506120302105
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