Systemic activation of NLRP3 inflammasome and plasma α-synuclein levels are correlated with motor severity and progression in Parkinson’s disease
Abstract Background Emerging evidence indicates that inflammasome-induced inflammation plays a crucial role in the pathogenesis of Parkinson’s disease (PD). Several proteins including α-synuclein trigger the activation of NLRP3 inflammasome. However, few studies examined whether inflammasomes are ac...
Main Authors: | Zheng Fan, Yu-Ting Pan, Zhi-Yuan Zhang, Hui Yang, Shu-Yue Yu, Yan Zheng, Jing-Hong Ma, Xiao-Min Wang |
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Format: | Article |
Language: | English |
Published: |
BMC
2020-01-01
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Series: | Journal of Neuroinflammation |
Subjects: | |
Online Access: | https://doi.org/10.1186/s12974-019-1670-6 |
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