Flavonoids, Flavonoid Subclasses, and Esophageal Cancer Risk: A Meta-Analysis of Epidemiologic Studies
Flavonoids have been suggested to play a chemopreventive role in carcinogenesis. However, the epidemiologic studies assessing dietary intake of flavonoids and esophageal cancer risk have yielded inconsistent results. This study was designed to examine the association between flavonoids, each flavono...
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doaj-888a5991bc7d4921966d867f4db272c02020-11-24T21:32:26ZengMDPI AGNutrients2072-66432016-06-018635010.3390/nu8060350nu8060350Flavonoids, Flavonoid Subclasses, and Esophageal Cancer Risk: A Meta-Analysis of Epidemiologic StudiesLingling Cui0Xinxin Liu1Yalan Tian2Chen Xie3Qianwen Li4Han Cui5Changqing Sun6College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, ChinaCollege of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, ChinaCollege of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, ChinaCollege of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, ChinaCollege of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, ChinaCollege of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, ChinaCollege of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, ChinaFlavonoids have been suggested to play a chemopreventive role in carcinogenesis. However, the epidemiologic studies assessing dietary intake of flavonoids and esophageal cancer risk have yielded inconsistent results. This study was designed to examine the association between flavonoids, each flavonoid subclass, and the risk of esophageal cancer with a meta-analysis approach. We searched for all relevant studies with a prospective cohort or case-control study design published from January 1990 to April 2016, using PUBMED, EMBASE, and Web of Science. Pooled odds ratios (ORs) were calculated using fixed or random-effect models. In total, seven articles including 2629 cases and 481,193 non-cases were selected for the meta-analysis. Comparing the highest-intake patients with the lowest-intake patients for total flavonoids and for each flavonoid subclass, we found that anthocyanidins (OR = 0.60, 95% CI: 0.49–0.74), flavanones (OR = 0.65, 95% CI: 0.49–0.86), and flavones (OR = 0.78, 95% CI 0.64–0.95) were inversely associated with the risk of esophageal cancer. However, total flavonoids showed marginal association with esophageal cancer risk (OR = 0.78, 95% CI: 0.59–1.04). In conclusion, our study suggested that dietary intake of total flavonoids, anthocyanidins, flavanones, and flavones might reduce the risk of esophageal cancer.http://www.mdpi.com/2072-6643/8/6/350flavonoidsesophageal cancermeta-analysis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lingling Cui Xinxin Liu Yalan Tian Chen Xie Qianwen Li Han Cui Changqing Sun |
spellingShingle |
Lingling Cui Xinxin Liu Yalan Tian Chen Xie Qianwen Li Han Cui Changqing Sun Flavonoids, Flavonoid Subclasses, and Esophageal Cancer Risk: A Meta-Analysis of Epidemiologic Studies Nutrients flavonoids esophageal cancer meta-analysis |
author_facet |
Lingling Cui Xinxin Liu Yalan Tian Chen Xie Qianwen Li Han Cui Changqing Sun |
author_sort |
Lingling Cui |
title |
Flavonoids, Flavonoid Subclasses, and Esophageal Cancer Risk: A Meta-Analysis of Epidemiologic Studies |
title_short |
Flavonoids, Flavonoid Subclasses, and Esophageal Cancer Risk: A Meta-Analysis of Epidemiologic Studies |
title_full |
Flavonoids, Flavonoid Subclasses, and Esophageal Cancer Risk: A Meta-Analysis of Epidemiologic Studies |
title_fullStr |
Flavonoids, Flavonoid Subclasses, and Esophageal Cancer Risk: A Meta-Analysis of Epidemiologic Studies |
title_full_unstemmed |
Flavonoids, Flavonoid Subclasses, and Esophageal Cancer Risk: A Meta-Analysis of Epidemiologic Studies |
title_sort |
flavonoids, flavonoid subclasses, and esophageal cancer risk: a meta-analysis of epidemiologic studies |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2016-06-01 |
description |
Flavonoids have been suggested to play a chemopreventive role in carcinogenesis. However, the epidemiologic studies assessing dietary intake of flavonoids and esophageal cancer risk have yielded inconsistent results. This study was designed to examine the association between flavonoids, each flavonoid subclass, and the risk of esophageal cancer with a meta-analysis approach. We searched for all relevant studies with a prospective cohort or case-control study design published from January 1990 to April 2016, using PUBMED, EMBASE, and Web of Science. Pooled odds ratios (ORs) were calculated using fixed or random-effect models. In total, seven articles including 2629 cases and 481,193 non-cases were selected for the meta-analysis. Comparing the highest-intake patients with the lowest-intake patients for total flavonoids and for each flavonoid subclass, we found that anthocyanidins (OR = 0.60, 95% CI: 0.49–0.74), flavanones (OR = 0.65, 95% CI: 0.49–0.86), and flavones (OR = 0.78, 95% CI 0.64–0.95) were inversely associated with the risk of esophageal cancer. However, total flavonoids showed marginal association with esophageal cancer risk (OR = 0.78, 95% CI: 0.59–1.04). In conclusion, our study suggested that dietary intake of total flavonoids, anthocyanidins, flavanones, and flavones might reduce the risk of esophageal cancer. |
topic |
flavonoids esophageal cancer meta-analysis |
url |
http://www.mdpi.com/2072-6643/8/6/350 |
work_keys_str_mv |
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