The Impact of Korean Medicine Treatment on the Incidence of Parkinson’s Disease in Patients with Inflammatory Bowel Disease: A Nationwide Population-Based Cohort Study in South Korea
We aimed to investigate the association between Korean medicine (KM) treatment and the risk of Parkinson’s Disease (PD) in patients with inflammatory bowel disease (IBD) in South Korea. This study analyzed data from the National Health Insurance Service-Senior cohort in South Korea. The 1816 IBD pat...
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doaj-88a83bd9b4e74934b2328ac9a40bdd662020-11-25T01:19:55ZengMDPI AGJournal of Clinical Medicine2077-03832020-07-0192422242210.3390/jcm9082422The Impact of Korean Medicine Treatment on the Incidence of Parkinson’s Disease in Patients with Inflammatory Bowel Disease: A Nationwide Population-Based Cohort Study in South KoreaHyeonseok Noh0Jeongju Jang1Seungwon Kwon2Seung-Yeon Cho3Woo-Sang Jung4Sang-Kwan Moon5Jung-Mi Park6Chang-Nam Ko7Ho Kim8Seong-Uk Park9Department of Clinical Korean Medicine, Graduate School, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, KoreaGraduate School of Public Health, Seoul National University, 1, Gwanak-ro, Gwanak-gu, Seoul 151-742, KoreaDepartment of Clinical Korean Medicine, Graduate School, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, KoreaDepartment of Clinical Korean Medicine, Graduate School, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, KoreaDepartment of Clinical Korean Medicine, Graduate School, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, KoreaDepartment of Clinical Korean Medicine, Graduate School, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, KoreaDepartment of Clinical Korean Medicine, Graduate School, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, KoreaDepartment of Clinical Korean Medicine, Graduate School, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, KoreaDepartment of Public Health Science, Graduate School of Public Health & Institute of Health and Environment, Seoul National University, 1, Gwanak-ro, Gwanak-gu, Seoul 08826, KoreaDepartment of Clinical Korean Medicine, Graduate School, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, KoreaWe aimed to investigate the association between Korean medicine (KM) treatment and the risk of Parkinson’s Disease (PD) in patients with inflammatory bowel disease (IBD) in South Korea. This study analyzed data from the National Health Insurance Service-Senior cohort in South Korea. The 1816 IBD patients enrolled in the analysis comprised 411 who received only conventional treatment (monotherapy group) and 1405 who received both conventional and KM treatments (integrative therapy group). The risk of PD in patients with IBD was significantly lower in the integrative therapy group than in the monotherapy group after adjusting for confounding variables (adjusted hazard ratio (HR), 0.56; 95% confidence interval (CI) = 0.34–0.92). In the mild Charlson Comorbidity Index (CCI) group, the risk of PD in patients with IBD in the integrative therapy group was 0.39 times lower (adjusted HR, 95% CI = 0.20–0.77) than that in the monotherapy group. However, there was no significant difference in the risk of PD in patients with IBD between the integrative therapy and monotherapy groups among individuals with severe CCI (adjusted HR, 0.90; 95% CI = 0.41−1.96). IBD patients are at a decreased risk of PD when they receive integrative therapy. KM treatment may prevent PD in IBD patients.https://www.mdpi.com/2077-0383/9/8/2422Parkinson’s diseaseinflammatory bowel diseaseKorean medicineNational Health Insurance Service-Senior cohortnationwide population-based study |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hyeonseok Noh Jeongju Jang Seungwon Kwon Seung-Yeon Cho Woo-Sang Jung Sang-Kwan Moon Jung-Mi Park Chang-Nam Ko Ho Kim Seong-Uk Park |
spellingShingle |
Hyeonseok Noh Jeongju Jang Seungwon Kwon Seung-Yeon Cho Woo-Sang Jung Sang-Kwan Moon Jung-Mi Park Chang-Nam Ko Ho Kim Seong-Uk Park The Impact of Korean Medicine Treatment on the Incidence of Parkinson’s Disease in Patients with Inflammatory Bowel Disease: A Nationwide Population-Based Cohort Study in South Korea Journal of Clinical Medicine Parkinson’s disease inflammatory bowel disease Korean medicine National Health Insurance Service-Senior cohort nationwide population-based study |
author_facet |
Hyeonseok Noh Jeongju Jang Seungwon Kwon Seung-Yeon Cho Woo-Sang Jung Sang-Kwan Moon Jung-Mi Park Chang-Nam Ko Ho Kim Seong-Uk Park |
author_sort |
Hyeonseok Noh |
title |
The Impact of Korean Medicine Treatment on the Incidence of Parkinson’s Disease in Patients with Inflammatory Bowel Disease: A Nationwide Population-Based Cohort Study in South Korea |
title_short |
The Impact of Korean Medicine Treatment on the Incidence of Parkinson’s Disease in Patients with Inflammatory Bowel Disease: A Nationwide Population-Based Cohort Study in South Korea |
title_full |
The Impact of Korean Medicine Treatment on the Incidence of Parkinson’s Disease in Patients with Inflammatory Bowel Disease: A Nationwide Population-Based Cohort Study in South Korea |
title_fullStr |
The Impact of Korean Medicine Treatment on the Incidence of Parkinson’s Disease in Patients with Inflammatory Bowel Disease: A Nationwide Population-Based Cohort Study in South Korea |
title_full_unstemmed |
The Impact of Korean Medicine Treatment on the Incidence of Parkinson’s Disease in Patients with Inflammatory Bowel Disease: A Nationwide Population-Based Cohort Study in South Korea |
title_sort |
impact of korean medicine treatment on the incidence of parkinson’s disease in patients with inflammatory bowel disease: a nationwide population-based cohort study in south korea |
publisher |
MDPI AG |
series |
Journal of Clinical Medicine |
issn |
2077-0383 |
publishDate |
2020-07-01 |
description |
We aimed to investigate the association between Korean medicine (KM) treatment and the risk of Parkinson’s Disease (PD) in patients with inflammatory bowel disease (IBD) in South Korea. This study analyzed data from the National Health Insurance Service-Senior cohort in South Korea. The 1816 IBD patients enrolled in the analysis comprised 411 who received only conventional treatment (monotherapy group) and 1405 who received both conventional and KM treatments (integrative therapy group). The risk of PD in patients with IBD was significantly lower in the integrative therapy group than in the monotherapy group after adjusting for confounding variables (adjusted hazard ratio (HR), 0.56; 95% confidence interval (CI) = 0.34–0.92). In the mild Charlson Comorbidity Index (CCI) group, the risk of PD in patients with IBD in the integrative therapy group was 0.39 times lower (adjusted HR, 95% CI = 0.20–0.77) than that in the monotherapy group. However, there was no significant difference in the risk of PD in patients with IBD between the integrative therapy and monotherapy groups among individuals with severe CCI (adjusted HR, 0.90; 95% CI = 0.41−1.96). IBD patients are at a decreased risk of PD when they receive integrative therapy. KM treatment may prevent PD in IBD patients. |
topic |
Parkinson’s disease inflammatory bowel disease Korean medicine National Health Insurance Service-Senior cohort nationwide population-based study |
url |
https://www.mdpi.com/2077-0383/9/8/2422 |
work_keys_str_mv |
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