Increased Expression of Adherens Junction Components in Mouse Liver following Bile Duct Ligation
Adherens junctions, consisting of cadherins and catenins, are a group of cell-to-cell junctions that mediate mechanistic linkage between neighboring cells. By doing so, adherens junctions ensure direct intercellular contact and play an indispensable role in maintaining tissue architecture. Consideri...
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doaj-88ae591e2add46a080b8187e9b4900982020-11-25T02:01:24ZengMDPI AGBiomolecules2218-273X2019-10-0191063610.3390/biom9100636biom9100636Increased Expression of Adherens Junction Components in Mouse Liver following Bile Duct LigationRaf Van Campenhout0Sara Crespo Yanguas1Axelle Cooreman2Eva Gijbels3Kaat Leroy4Vânia Vilas-Boas5Nick Devoogdt6Serge Muyldermans7Bruno Cogliati8Mathieu Vinken9Department of In Vitro Toxicology and Dermato-Cosmetology, Vrije Universiteit Brussel, Laarbeeklaan 103, B-1090 Brussels, BelgiumDepartment of In Vitro Toxicology and Dermato-Cosmetology, Vrije Universiteit Brussel, Laarbeeklaan 103, B-1090 Brussels, BelgiumDepartment of In Vitro Toxicology and Dermato-Cosmetology, Vrije Universiteit Brussel, Laarbeeklaan 103, B-1090 Brussels, BelgiumDepartment of In Vitro Toxicology and Dermato-Cosmetology, Vrije Universiteit Brussel, Laarbeeklaan 103, B-1090 Brussels, BelgiumDepartment of In Vitro Toxicology and Dermato-Cosmetology, Vrije Universiteit Brussel, Laarbeeklaan 103, B-1090 Brussels, BelgiumDepartment of In Vitro Toxicology and Dermato-Cosmetology, Vrije Universiteit Brussel, Laarbeeklaan 103, B-1090 Brussels, BelgiumIn Vivo Cellular and Molecular Imaging Laboratory, Vrije Universiteit Brussel, Laarbeeklaan 103, B-1090 Brussels, BelgiumLaboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Pleinlaan 2, B-1050 Brussels, BelgiumDepartment of Pathology, School of Veterinary Medicine and Animal Science, University of São Paulo, 05508-270 São Paulo, BrazilDepartment of In Vitro Toxicology and Dermato-Cosmetology, Vrije Universiteit Brussel, Laarbeeklaan 103, B-1090 Brussels, BelgiumAdherens junctions, consisting of cadherins and catenins, are a group of cell-to-cell junctions that mediate mechanistic linkage between neighboring cells. By doing so, adherens junctions ensure direct intercellular contact and play an indispensable role in maintaining tissue architecture. Considering these critical functions, it is not surprising that adherens junctions are frequently involved in disease. In the present study, the effects of bile duct ligation—a surgical procedure to experimentally induce cholestatic and fibrotic liver pathology—on hepatic adherens junctions were investigated in mice. In essence, it was found that liver mRNA and protein levels of E-cadherin, β-catenin and γ-catenin drastically increase following bile duct ligation. These results could suggest a cytoprotective role for hepatic adherens junctions following bile duct ligation.https://www.mdpi.com/2218-273X/9/10/636cadherincateninliverfibrosischolestasis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Raf Van Campenhout Sara Crespo Yanguas Axelle Cooreman Eva Gijbels Kaat Leroy Vânia Vilas-Boas Nick Devoogdt Serge Muyldermans Bruno Cogliati Mathieu Vinken |
spellingShingle |
Raf Van Campenhout Sara Crespo Yanguas Axelle Cooreman Eva Gijbels Kaat Leroy Vânia Vilas-Boas Nick Devoogdt Serge Muyldermans Bruno Cogliati Mathieu Vinken Increased Expression of Adherens Junction Components in Mouse Liver following Bile Duct Ligation Biomolecules cadherin catenin liver fibrosis cholestasis |
author_facet |
Raf Van Campenhout Sara Crespo Yanguas Axelle Cooreman Eva Gijbels Kaat Leroy Vânia Vilas-Boas Nick Devoogdt Serge Muyldermans Bruno Cogliati Mathieu Vinken |
author_sort |
Raf Van Campenhout |
title |
Increased Expression of Adherens Junction Components in Mouse Liver following Bile Duct Ligation |
title_short |
Increased Expression of Adherens Junction Components in Mouse Liver following Bile Duct Ligation |
title_full |
Increased Expression of Adherens Junction Components in Mouse Liver following Bile Duct Ligation |
title_fullStr |
Increased Expression of Adherens Junction Components in Mouse Liver following Bile Duct Ligation |
title_full_unstemmed |
Increased Expression of Adherens Junction Components in Mouse Liver following Bile Duct Ligation |
title_sort |
increased expression of adherens junction components in mouse liver following bile duct ligation |
publisher |
MDPI AG |
series |
Biomolecules |
issn |
2218-273X |
publishDate |
2019-10-01 |
description |
Adherens junctions, consisting of cadherins and catenins, are a group of cell-to-cell junctions that mediate mechanistic linkage between neighboring cells. By doing so, adherens junctions ensure direct intercellular contact and play an indispensable role in maintaining tissue architecture. Considering these critical functions, it is not surprising that adherens junctions are frequently involved in disease. In the present study, the effects of bile duct ligation—a surgical procedure to experimentally induce cholestatic and fibrotic liver pathology—on hepatic adherens junctions were investigated in mice. In essence, it was found that liver mRNA and protein levels of E-cadherin, β-catenin and γ-catenin drastically increase following bile duct ligation. These results could suggest a cytoprotective role for hepatic adherens junctions following bile duct ligation. |
topic |
cadherin catenin liver fibrosis cholestasis |
url |
https://www.mdpi.com/2218-273X/9/10/636 |
work_keys_str_mv |
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