RETRACTED ARTICLE: A Comparative Study of the Toxicity of Polyethylene Glycol–Coated Cobalt Ferrite Nanospheres and Nanoparticles
Abstract We present a comparative study of the toxicity of polyethylene glycol (PEG)–coated cobalt ferrite nanoparticles and nanospheres. Nanoparticles were prepared by hydrothermal method while nanospheres were prepared by solvothermal technique. The surface of nanomaterials was successfully modifi...
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doaj-88ae9b6cf0314e10816b15c89aed17be2020-12-20T12:10:32ZengSpringerOpenNanoscale Research Letters1931-75731556-276X2019-12-0114111210.1186/s11671-019-3202-9RETRACTED ARTICLE: A Comparative Study of the Toxicity of Polyethylene Glycol–Coated Cobalt Ferrite Nanospheres and NanoparticlesShahnaz Akhtar0Qasim Khan1Shahzad Anwar2Ghafar Ali3Muhammad Maqbool4Maaz Khan5Shafqat Karim6Lan Gao7School of Life Sciences, Lanzhou UniversityShenzhen Key Laboratory of Flexible Memory Materials and Devices, College of Electronic Science and Technology, Shenzhen UniversityDepartment of Physics, Islamia College Peshawar (Chartered University)Nanomaterials Research Group, Physics Division PINSTECHDepartment of Clinical & Diagnostic Sciences, The University of Alabama at BirminghamNanomaterials Research Group, Physics Division PINSTECHNanomaterials Research Group, Physics Division PINSTECHSchool of Life Sciences, Lanzhou UniversityAbstract We present a comparative study of the toxicity of polyethylene glycol (PEG)–coated cobalt ferrite nanoparticles and nanospheres. Nanoparticles were prepared by hydrothermal method while nanospheres were prepared by solvothermal technique. The surface of nanomaterials was successfully modified with polyethylene glycol. To investigate the morphology of the prepared samples, X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, Raman spectroscopy, thermogravimetric analysis (TGA), and electron microscopy techniques were employed. Structural analyses confirmed the formation of polycrystalline cobalt ferrite nanoparticles with diameters in the range 20–25 nm and nanospheres in the range 80–100 nm, respectively. Kunming SPF mice (female, 6–8 weeks old) were used to investigate the toxicity induced by cobalt ferrite nanoparticles and nanospheres in different organs of the mice. Biodistribution studies, biochemical indices, histopathological assessments, inflammatory factors, oxidation and antioxidant levels, and cytotoxicity tests were performed to assess the toxicity induced by cobalt ferrite nanoparticles and nanospheres in mice. Cobalt ferrite nanospheres were found to be more toxic than the nanoparticles and curcumin was proved to be a good healing agent for the toxicity induced by PEG-coated cobalt ferrite nanomaterials in mice.https://doi.org/10.1186/s11671-019-3202-9Cobalt ferriteToxicityNanospheresBiodistributionSolvothermal techniqueInflammatory factors |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Shahnaz Akhtar Qasim Khan Shahzad Anwar Ghafar Ali Muhammad Maqbool Maaz Khan Shafqat Karim Lan Gao |
spellingShingle |
Shahnaz Akhtar Qasim Khan Shahzad Anwar Ghafar Ali Muhammad Maqbool Maaz Khan Shafqat Karim Lan Gao RETRACTED ARTICLE: A Comparative Study of the Toxicity of Polyethylene Glycol–Coated Cobalt Ferrite Nanospheres and Nanoparticles Nanoscale Research Letters Cobalt ferrite Toxicity Nanospheres Biodistribution Solvothermal technique Inflammatory factors |
author_facet |
Shahnaz Akhtar Qasim Khan Shahzad Anwar Ghafar Ali Muhammad Maqbool Maaz Khan Shafqat Karim Lan Gao |
author_sort |
Shahnaz Akhtar |
title |
RETRACTED ARTICLE: A Comparative Study of the Toxicity of Polyethylene Glycol–Coated Cobalt Ferrite Nanospheres and Nanoparticles |
title_short |
RETRACTED ARTICLE: A Comparative Study of the Toxicity of Polyethylene Glycol–Coated Cobalt Ferrite Nanospheres and Nanoparticles |
title_full |
RETRACTED ARTICLE: A Comparative Study of the Toxicity of Polyethylene Glycol–Coated Cobalt Ferrite Nanospheres and Nanoparticles |
title_fullStr |
RETRACTED ARTICLE: A Comparative Study of the Toxicity of Polyethylene Glycol–Coated Cobalt Ferrite Nanospheres and Nanoparticles |
title_full_unstemmed |
RETRACTED ARTICLE: A Comparative Study of the Toxicity of Polyethylene Glycol–Coated Cobalt Ferrite Nanospheres and Nanoparticles |
title_sort |
retracted article: a comparative study of the toxicity of polyethylene glycol–coated cobalt ferrite nanospheres and nanoparticles |
publisher |
SpringerOpen |
series |
Nanoscale Research Letters |
issn |
1931-7573 1556-276X |
publishDate |
2019-12-01 |
description |
Abstract We present a comparative study of the toxicity of polyethylene glycol (PEG)–coated cobalt ferrite nanoparticles and nanospheres. Nanoparticles were prepared by hydrothermal method while nanospheres were prepared by solvothermal technique. The surface of nanomaterials was successfully modified with polyethylene glycol. To investigate the morphology of the prepared samples, X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, Raman spectroscopy, thermogravimetric analysis (TGA), and electron microscopy techniques were employed. Structural analyses confirmed the formation of polycrystalline cobalt ferrite nanoparticles with diameters in the range 20–25 nm and nanospheres in the range 80–100 nm, respectively. Kunming SPF mice (female, 6–8 weeks old) were used to investigate the toxicity induced by cobalt ferrite nanoparticles and nanospheres in different organs of the mice. Biodistribution studies, biochemical indices, histopathological assessments, inflammatory factors, oxidation and antioxidant levels, and cytotoxicity tests were performed to assess the toxicity induced by cobalt ferrite nanoparticles and nanospheres in mice. Cobalt ferrite nanospheres were found to be more toxic than the nanoparticles and curcumin was proved to be a good healing agent for the toxicity induced by PEG-coated cobalt ferrite nanomaterials in mice. |
topic |
Cobalt ferrite Toxicity Nanospheres Biodistribution Solvothermal technique Inflammatory factors |
url |
https://doi.org/10.1186/s11671-019-3202-9 |
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