Prognostic and clinicopathological significance of SNHG20 in human cancers: a meta-analysis
Abstract Background It has been widely reported that the expression levels of SNHG20 are elevated in diverse types of cancers, indicating that SNHG20 may participate in cancer initiation and development. Besides, accumulating evidence reveals that SNHG20 overexpression is also connected with poor cl...
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doaj-88b40473deb04644aeef7eb4057432bc2020-11-25T03:12:40ZengBMCCancer Cell International1475-28672020-07-0120111110.1186/s12935-020-01403-8Prognostic and clinicopathological significance of SNHG20 in human cancers: a meta-analysisHanlong Zhu0Si Zhao1Ruonan Jiao2Huishan Wang3Ruiyi Tang4Xiaochao Wu5Fei Wang6Xianxiu Ge7Quanpeng Li8Lin Miao9Medical Centre for Digestive Diseases, The Second Affiliated Hospital of Nanjing Medical UniversityMedical Centre for Digestive Diseases, The Second Affiliated Hospital of Nanjing Medical UniversityMedical Centre for Digestive Diseases, The Second Affiliated Hospital of Nanjing Medical UniversityMedical Centre for Digestive Diseases, The Second Affiliated Hospital of Nanjing Medical UniversityMedical Centre for Digestive Diseases, The Second Affiliated Hospital of Nanjing Medical UniversityMedical Centre for Digestive Diseases, The Second Affiliated Hospital of Nanjing Medical UniversityMedical Centre for Digestive Diseases, The Second Affiliated Hospital of Nanjing Medical UniversityMedical Centre for Digestive Diseases, The Second Affiliated Hospital of Nanjing Medical UniversityMedical Centre for Digestive Diseases, The Second Affiliated Hospital of Nanjing Medical UniversityMedical Centre for Digestive Diseases, The Second Affiliated Hospital of Nanjing Medical UniversityAbstract Background It has been widely reported that the expression levels of SNHG20 are elevated in diverse types of cancers, indicating that SNHG20 may participate in cancer initiation and development. Besides, accumulating evidence reveals that SNHG20 overexpression is also connected with poor clinical outcomes among cancer patients. Herein, we carry out a systematic meta-analysis to further determine the prognostic and clinical significance of SNHG20 expression in various human cancers. Methods Qualifying publications were selected by searching for keywords in PubMed, Embase, Web of Science and Cochrane Library databases, up to September 1, 2019. Pooled hazard ratio (HR) or odds ratio (OR) with corresponding 95% confidence interval (CI) was computed to estimate the strength of association between SNHG20 and survival of cancer patients or clinicopathology using Stata 14.0 software. Results In total, 15 studies encompassing 1187 patients met the inclusion criteria were ultimately enrolled for analysis. According to the meta-analysis, patients with high SNHG20 expression were markedly linked to poorer overall survival (OS) (pooled HR = 2.47, 95% CI 2.05–2.98, P = 0.000) and disease-free survival/recurrence-free survival/progression-free survival (DFS/RFS/PFS) (pooled HR = 2.37, 95% CI 1.60–3.51, P = 0.000). Additionally, regarding clinicopathology of patients, enhanced SNHG20 was correlated with advanced tumour‐node‐metastasis (TNM) stage (OR = 2.80, 95% CI 2.00–3.93, P = 0.000), larger tumor size (OR = 3.08, 95% CI 2.11–4.51, P = 0.000), positive lymph nodes metastasis (OR = 2.99, 95% CI 2.08–4.31, P = 0.000), higher tumor stage (OR = 4.51, 95% CI 2.17–9.37, P = 0.000) and worse histological grade (OR = 1.95, 95% CI 1.44–2.63, P = 0.000), but not with gender, smoking status or distant metastasis. Conclusions Up-regulated SNHG20 expression is ubiquitous in different kinds of cancers. Moreover, up-regulated SNHG20 expression is capable of serving as an innovative predictive factor of inferior clinical outcomes in cancer patients. Nevertheless, higher-quality multicenter studies are required to corroborate our results.http://link.springer.com/article/10.1186/s12935-020-01403-8SNHG20lncRNACancerPrognosisMeta-analysis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hanlong Zhu Si Zhao Ruonan Jiao Huishan Wang Ruiyi Tang Xiaochao Wu Fei Wang Xianxiu Ge Quanpeng Li Lin Miao |
spellingShingle |
Hanlong Zhu Si Zhao Ruonan Jiao Huishan Wang Ruiyi Tang Xiaochao Wu Fei Wang Xianxiu Ge Quanpeng Li Lin Miao Prognostic and clinicopathological significance of SNHG20 in human cancers: a meta-analysis Cancer Cell International SNHG20 lncRNA Cancer Prognosis Meta-analysis |
author_facet |
Hanlong Zhu Si Zhao Ruonan Jiao Huishan Wang Ruiyi Tang Xiaochao Wu Fei Wang Xianxiu Ge Quanpeng Li Lin Miao |
author_sort |
Hanlong Zhu |
title |
Prognostic and clinicopathological significance of SNHG20 in human cancers: a meta-analysis |
title_short |
Prognostic and clinicopathological significance of SNHG20 in human cancers: a meta-analysis |
title_full |
Prognostic and clinicopathological significance of SNHG20 in human cancers: a meta-analysis |
title_fullStr |
Prognostic and clinicopathological significance of SNHG20 in human cancers: a meta-analysis |
title_full_unstemmed |
Prognostic and clinicopathological significance of SNHG20 in human cancers: a meta-analysis |
title_sort |
prognostic and clinicopathological significance of snhg20 in human cancers: a meta-analysis |
publisher |
BMC |
series |
Cancer Cell International |
issn |
1475-2867 |
publishDate |
2020-07-01 |
description |
Abstract Background It has been widely reported that the expression levels of SNHG20 are elevated in diverse types of cancers, indicating that SNHG20 may participate in cancer initiation and development. Besides, accumulating evidence reveals that SNHG20 overexpression is also connected with poor clinical outcomes among cancer patients. Herein, we carry out a systematic meta-analysis to further determine the prognostic and clinical significance of SNHG20 expression in various human cancers. Methods Qualifying publications were selected by searching for keywords in PubMed, Embase, Web of Science and Cochrane Library databases, up to September 1, 2019. Pooled hazard ratio (HR) or odds ratio (OR) with corresponding 95% confidence interval (CI) was computed to estimate the strength of association between SNHG20 and survival of cancer patients or clinicopathology using Stata 14.0 software. Results In total, 15 studies encompassing 1187 patients met the inclusion criteria were ultimately enrolled for analysis. According to the meta-analysis, patients with high SNHG20 expression were markedly linked to poorer overall survival (OS) (pooled HR = 2.47, 95% CI 2.05–2.98, P = 0.000) and disease-free survival/recurrence-free survival/progression-free survival (DFS/RFS/PFS) (pooled HR = 2.37, 95% CI 1.60–3.51, P = 0.000). Additionally, regarding clinicopathology of patients, enhanced SNHG20 was correlated with advanced tumour‐node‐metastasis (TNM) stage (OR = 2.80, 95% CI 2.00–3.93, P = 0.000), larger tumor size (OR = 3.08, 95% CI 2.11–4.51, P = 0.000), positive lymph nodes metastasis (OR = 2.99, 95% CI 2.08–4.31, P = 0.000), higher tumor stage (OR = 4.51, 95% CI 2.17–9.37, P = 0.000) and worse histological grade (OR = 1.95, 95% CI 1.44–2.63, P = 0.000), but not with gender, smoking status or distant metastasis. Conclusions Up-regulated SNHG20 expression is ubiquitous in different kinds of cancers. Moreover, up-regulated SNHG20 expression is capable of serving as an innovative predictive factor of inferior clinical outcomes in cancer patients. Nevertheless, higher-quality multicenter studies are required to corroborate our results. |
topic |
SNHG20 lncRNA Cancer Prognosis Meta-analysis |
url |
http://link.springer.com/article/10.1186/s12935-020-01403-8 |
work_keys_str_mv |
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